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custirsen sodium The eicosasodium salt of a mixed-backbone antisense oligodeoxynucleotide with chemosensitizing properties. Custirsen inhibits testosterone-repressed prostate message-2 (TRPM-2). Administration of custirsen abrogates the anti-apoptotic effect of TRPM-2, thereby sensitizing cells to chemotherapy and resulting in tumor cell death. TRPM-2 is an anti-apoptotic clusterin that is overexpressed by prostate cancer cells and is associated with chemoresistance. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20090115062358im_/http://www.cancer.gov/images/spacer.gif) | Antisense Clusterin Antisense Testosterone-Repressed Prostate Message 2 Antisense TRPM-2 clusterin antisense oligonucleotide TRPM-2 Antisense | | ![](https://webarchive.library.unt.edu/eot2008/20090115062358im_/http://www.cancer.gov/images/spacer.gif) | Code names: | ![](https://webarchive.library.unt.edu/eot2008/20090115062358im_/http://www.cancer.gov/images/spacer.gif) | ISIS 112989 OGX-011 | | ![](https://webarchive.library.unt.edu/eot2008/20090115062358im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20090115062358im_/http://www.cancer.gov/images/spacer.gif) | DNA, d(P-thio)([2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2- methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]m5rC-A-G-C-A-G-A-G-T-C-T-T-C-A-[2'-O-(2- methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2- methoxyethyl)]m5rU), eicosasodium salt | | ![](https://webarchive.library.unt.edu/eot2008/20090115062358im_/http://www.cancer.gov/images/spacer.gif) |
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