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mechlorethamine hydrochloride The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intemediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20090115051340im_/http://www.cancer.gov/images/spacer.gif) | chloramin chlorethamine HCl chlorethamine hydrochloride chlorethazine chlorethazine hydrochloride chlormethine chlormethine hydrochloride chloromethine HCl mechlorethamine mechlorethamine HCl methylchlorethamine Mustard mustargen HCl mustargen hydrochloride Mustine NH-2 N-Lost | | ![](https://webarchive.library.unt.edu/eot2008/20090115051340im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090115051340im_/http://www.cancer.gov/images/spacer.gif) | Mustargen | | ![](https://webarchive.library.unt.edu/eot2008/20090115051340im_/http://www.cancer.gov/images/spacer.gif) | Foreign brand names: | ![](https://webarchive.library.unt.edu/eot2008/20090115051340im_/http://www.cancer.gov/images/spacer.gif) | Caryolysine Cloramin Erasol Mustine Hydrochloride Onco-Cloramin | | ![](https://webarchive.library.unt.edu/eot2008/20090115051340im_/http://www.cancer.gov/images/spacer.gif) | Abbreviations: | ![](https://webarchive.library.unt.edu/eot2008/20090115051340im_/http://www.cancer.gov/images/spacer.gif) | HN 2 NM | | ![](https://webarchive.library.unt.edu/eot2008/20090115051340im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090115051340im_/http://www.cancer.gov/images/spacer.gif) | WR-147650 | | ![](https://webarchive.library.unt.edu/eot2008/20090115051340im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure names: | ![](https://webarchive.library.unt.edu/eot2008/20090115051340im_/http://www.cancer.gov/images/spacer.gif) | - bis(2-chloroethyl)methylamine
- ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl
- methylbis(beta-chloroethyl)amine
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