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mitotane A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20090115045839im_/http://www.cancer.gov/images/spacer.gif) | Chloditan Chlodithane Khloditan Mytotan o,p'-DDD Ortho,para-DDD | | ![](https://webarchive.library.unt.edu/eot2008/20090115045839im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090115045839im_/http://www.cancer.gov/images/spacer.gif) | Lysodren | | ![](https://webarchive.library.unt.edu/eot2008/20090115045839im_/http://www.cancer.gov/images/spacer.gif) | Foreign brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090115045839im_/http://www.cancer.gov/images/spacer.gif) | Lisodren | | ![](https://webarchive.library.unt.edu/eot2008/20090115045839im_/http://www.cancer.gov/images/spacer.gif) | Abbreviations: | ![](https://webarchive.library.unt.edu/eot2008/20090115045839im_/http://www.cancer.gov/images/spacer.gif) | DDD o,p' - DDD | | ![](https://webarchive.library.unt.edu/eot2008/20090115045839im_/http://www.cancer.gov/images/spacer.gif) | Code names: | ![](https://webarchive.library.unt.edu/eot2008/20090115045839im_/http://www.cancer.gov/images/spacer.gif) | CB-313 WR-13045 | | ![](https://webarchive.library.unt.edu/eot2008/20090115045839im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure names: | ![](https://webarchive.library.unt.edu/eot2008/20090115045839im_/http://www.cancer.gov/images/spacer.gif) | - 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
- 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
- 2-(2-chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane
- 2,2-bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane
- 2,4'-dichlorodiphenyldichloroethane
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