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recombinant interleukin-18 A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-18 (IL-18). Produced primarily by macrophages, IL-18 induces the production of interferon-gamma (IFN-gamma), and enhances the activity of natural killer (NK) and cytotoxic T lymphocytes (CTL). As a potential immunotherapeutic agent, IL-18 displays antitumor effects in vitro and in animal models. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20090115044314im_/http://www.cancer.gov/images/spacer.gif) | IFN-gamma-inducing factor interferon-gamma-inducing factor | | ![](https://webarchive.library.unt.edu/eot2008/20090115044314im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090115044314im_/http://www.cancer.gov/images/spacer.gif) | IL-18 | | ![](https://webarchive.library.unt.edu/eot2008/20090115044314im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090115044314im_/http://www.cancer.gov/images/spacer.gif) | SB-485232 | | ![](https://webarchive.library.unt.edu/eot2008/20090115044314im_/http://www.cancer.gov/images/spacer.gif) |
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