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Guide to the Application of Genotyping to Tuberculosis Prevention
and Control
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Introduction to Tuberculosis Genotyping
Introduction to this Guide
This guide provides an introduction to the application of tuberculosis
(TB) genotyping to TB control practices and to the Centers for Disease
Control and Prevention (CDC) TB Genotyping Program. It was written
by the National Tuberculosis Controllers Association (NTCA)/CDC
Advisory Group on Tuberculosis Genotyping and is intended for TB
controllers, epidemiologists, laboratorians, and other program staff
members who will be involved in submitting isolates for genotyping,
analyzing and responding to genotyping results, or using genotyping
data to monitor TB transmission trends.
This guide does not contain specific directions on how a TB control
program must carry out its genotyping program. The CDC genotyping
program is not a research effort, and participating state and local
programs are not required to carry out a protocol, submit a certain
number of isolates, or collect specific data. Rather, this guide
provides general guidance about how to utilize the genotyping laboratories,
how to understand genotyping results, and how to apply those results
to improve TB control practices. For those interested in the specific
procedures used by other TB genotyping programs, the Maryland TB
program and the New York City TB program have agreed to share their
procedure manuals; those documents can be downloaded from our TB
genotyping WebBoard at http://web-tb.forum.cdc.gov.
Understanding TB genotyping results is not difficult, but it involves
learning a new vocabulary. It also involves establishing new procedures
to ensure that the genotyping results can easily be combined with
appropriate epidemiologic data to identify instances of recent TB
transmission. This new vocabulary and these new procedures are the
focus of this guide. Hopefully, we have developed a guide that helps
you master this new subject.
In the following paragraphs, key concepts are introduced. These
concepts are developed further in the relevant chapters of the guide.
Finally, a glossary in Appendix A defines important concepts. Throughout
the guide, tables, figures, and text boxes sum up important points
made in the text. An electronic copy of this guide, the Isolate
Submission Form, and other genotyping documents can be downloaded
from the CDC Tuberculosis Genotyping Program’s WebBoard at http://web-tb.forum.cdc.gov.
Copies of the guide can be ordered by sending an e-mail to
TBGenotyping@cdc.gov.
Last Reviewed: 05/18/2008 Content Source: Division of Tuberculosis Elimination
National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention
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