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romidepsin
A bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum. After intracellular activation, romidepsin binds to and inhibits histone deacetylase (HDAC), resulting in alterations in gene expression and the induction of cell differentiation, cell cycle arrest, and apoptosis. This agent also inhibits hypoxia-induced angiogenesis and depletes several heat shock protein 90 (Hsp90)-dependent oncoproteins. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | depsipeptide | | | | Code names: | | FK228
FR901228
NSC 630176 | | | | Chemical structure names: | | - L-valine, N-(3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(Z)-2,3 -didehydro-2-aminobutanoyl-, xi-lactone, cyclic (1-2)-disulfide, (S-(E))-
- N-[(3S,4E-3-hydroxy-7-mercapto-1-oxo-4-heptenyl]-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoyl-L-valine, (4->1) lactone, cyclic
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