SUNDAY, DECEMBER 7, 2003 |
8:00 – 8:30 AM |
Registration, Continental Breakfast |
8:30 – 9:00 AM |
Welcome and Introductions
Helmut Zarbl, FHCRC, Chair, TRC Steering Committee
William Suk, Director, Center for Risk and Integrated Sciences (CRIS), DERT |
Scientific Sessions |
9:00-10:50 AM |
DISEASE MECHANISMS
Chair: Leona D. Samson, Professor of Biological Engineering and Director of the Center for Environmental Health Sciences, Massachusetts Institute of Technology |
9:00 AM |
Insulin-like Growth Factor Signaling in Neural Cell Development
Stephen Back, Department of Pediatrics, Oregon Health and Science University |
9:20 AM |
Identification of Dss1 as a TPA-responsive Gene Expressed in Keratinocyte Progenitor Cells, with Possible Involvement in Early Skin Tumorigenesis
Sung-Jen Wei, National Center for Toxicogenomics, NIEHS |
9:50 AM |
Global Gene Expression In The Developing Mouse Cerebral Cortex And Cerebellum Is Perturbed By The Genotoxin Methylazoxymethanol (Mam)
Melissa Standley, Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University |
10:10 AM |
Gene Expression Analysis of the Idiopathic Interstitial Pneumonias
Ivana V. Yang, Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center |
10:30 AM |
Characterization of Strain Susceptibility Differences to the Colorectal Carcinogen Azoxymethane
Anika C. Bissahoyo, University of North Carolina at Chapel Hill |
10:50-11:10 AM |
Break |
11:10-12:20 AM |
SUSCEPTIBILITY
Chair: William K. Kaufmann, Director, UNC Program in Toxicogenomics, University of North Carolina at Chapel Hill |
11:10 AM |
Ionizing radiation-induced changes in gene expression are associated with ATM- and p53-dependent G1 checkpoint function in diploid human fibroblasts
Tong Zhou, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill |
11:30 AM |
Elucidation of pATM-Dependent and -Independent Gene Expression Changes after oxidative stress, γ- and UV-Irradiation.
Alexandra N. Heinloth, NIEHS |
12:00 PM |
Genetic And Temporal Determinants Of Pesticide Sensitivity In Children: Role Of Paraoxonase (Pon1)
Toby B. Cole, University of Washington |
12:20-1:40 PM |
Buffet Lunch, Informal Scientific Interactions |
1:40-3:20 PM |
COMPARATIVE GENOMICS
Chair: Terrence J. Kavanagh, Professor, Department of Environmental & Occupational Health Sciences, University of Washington |
1:40 PM |
Gene expression profiling of normal mammary tissue from rat strains with differential genetic susceptibilities to mammary carcinogenesis
Syed T. Haider, Center for BioArrays, University of Washington |
2:00 PM |
Cell-Type Specific Responses To Chemotherapeutics In Breast Cancer
Melissa A. Troester, University of North Carolina at Chapel Hill |
2:20 PM |
Toxicogenomic profiling in primary hepatocyte culture models from rodents and humans
Curtis J. Omiecinski, The Pennsylvania State University |
2:40 PM |
Genetic Study of C. elegans Innate Immune Response
Alejandro Aballay, Duke University Medical Center |
3:00 PM |
A SNP in NCAM1 shows association with human neural tube defects
Kristen L. Bastress, Duke University Medical Center |
3:20-3:40 PM |
Break |
3:40-5:00 PM |
PREDICTIVE TOXICOLOGY
Chair: Richard S. Paules, Director, Microarray Group and Toxicogenomics Facilitator, NIEHS |
3:40 PM |
Gene Expression Analysis of Mismatch Repair Deficient E. coli Treated with Cisplatin
Jennifer L. Robbins, Massachusetts Institute of Technology |
4:10 PM |
Pcb-Induced Changes In Gene Expression Assayed Across Multiple Cell Types And Pcb Congeners
Christine Kostek Brown, Boston Biomedical Research Institute |
4:50 PM |
Complex Responses To Damaging Agents
Lisiane B. Meira, Massachusetts Institute of Technology |
5:00-6:45 PM |
Poster Session and Social Hour
Adjourn and Transport to Ray’s Boathouse Restaurant |
7:30PM |
Dinner and Keynote Speaker
Inter-disciplinary Research: Translation of Genomics to Reduce Risk
Bill Suk, Director, Center for Risk and Integrated Sciences, DERT, NIEHS |
MONDAY, DECEMBER 8, 2003 |
8:00 – 8:30 AM |
Continental Breakfast |
Mini Symposium: Integration of "Omics" Data |
8:30-9:25 AM |
KEYNOTE: PROTEOMICS
A review of shotgun proteomic methods for discovery based projects.
David Robinson Goodlett, Director Proteomics Facility, Institute for Systems Biology, Seattle |
9:25-10:20 AM |
KEYNOTE: METABOLOMICS
Metabonomics: challenges and opportunities for integrating metabolite profiling in systems biology.
Craig E. Thomas, Head, Lead Optimization Toxicology, Lilly Research Laboratories, Indianapolis |
10:20-10:35 AM |
Break |
10:35-11:30 AM |
KEYNOTE: SYSTEMS BIOLOGY
Querying interaction networks for pathways: a new paradigm (perhaps) for toxicogenomics.
Trey Ideker, Professor of Bioengineering, University of California at San Diego |
11:30-12:00 AM |
PANEL DISCUSSION
(Keynote Speakers, David Eaton, Peter Spencer, Jonathan Freedman) |
12:00-1:00 PM |
Box Lunch |
Presentations and Open Dialog with Commercial Suppliers |
1:00-1:20 PM |
From Research to Results: CodeLink Three Dimensional Bioarrays for Gene Expression Analysis
Tamma Kaysser-Kranich, Amersham Biosciences |
1:20-1:40 PM |
Quantitative Analysis of Gene Expression Using Chemiluminescent Detection on Microarrays
Criss Walworth, Applied Biosystems |
1:40-2:00 PM |
Genechip® Microarray Applications In Toxicogenomics
Jacques Retief, Affymetrix |
2:00-2:20 PM |
Using Flexible Inkjet Microarray Manufacturing for Agilent Catalog Microarrays
Erik Bjeldanes, Agilent Technologies |
2:20-2:40 PM |
Break |
TRC Business Meeting – Closed Session |
2:40-5:00 PM |
Cooperative Research Program
- TRC Publication
- Standardization Experiment 3 (time permitting)
|
5:00-6:30 PM |
TRC Steering Committee Meeting |