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Agenda

TRC Semi-Annual Meeting

Dec. 7 - 8, 2003
Pelton Auditorium
The Fred Hutchinson Cancer Research Center
Seattle, Washington


SUNDAY, DECEMBER 7, 2003
8:00 – 8:30 AM Registration, Continental Breakfast
8:30 – 9:00 AM Welcome and Introductions

Helmut Zarbl, FHCRC, Chair, TRC Steering Committee
William Suk, Director, Center for Risk and Integrated Sciences (CRIS), DERT

Scientific Sessions
9:00-10:50 AM DISEASE MECHANISMS

Chair: Leona D. Samson, Professor of Biological Engineering and Director of the Center for Environmental Health Sciences, Massachusetts Institute of Technology

9:00 AM Insulin-like Growth Factor Signaling in Neural Cell Development

Stephen Back, Department of Pediatrics, Oregon Health and Science University

9:20 AM Identification of Dss1 as a TPA-responsive Gene Expressed in Keratinocyte Progenitor Cells, with Possible Involvement in Early Skin Tumorigenesis

Sung-Jen Wei, National Center for Toxicogenomics, NIEHS

9:50 AM Global Gene Expression In The Developing Mouse Cerebral Cortex And Cerebellum Is Perturbed By The Genotoxin Methylazoxymethanol (Mam)

Melissa Standley, Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University

10:10 AM Gene Expression Analysis of the Idiopathic Interstitial Pneumonias

Ivana V. Yang, Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center

10:30 AM Characterization of Strain Susceptibility Differences to the Colorectal Carcinogen Azoxymethane

Anika C. Bissahoyo, University of North Carolina at Chapel Hill

10:50-11:10 AM Break
11:10-12:20 AM SUSCEPTIBILITY

Chair: William K. Kaufmann, Director, UNC Program in Toxicogenomics, University of North Carolina at Chapel Hill

11:10 AM Ionizing radiation-induced changes in gene expression are associated with ATM- and p53-dependent G1 checkpoint function in diploid human fibroblasts

Tong Zhou, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill

11:30 AM Elucidation of pATM-Dependent and -Independent Gene Expression Changes after oxidative stress, γ- and UV-Irradiation.

Alexandra N. Heinloth, NIEHS

12:00 PM Genetic And Temporal Determinants Of Pesticide Sensitivity In Children: Role Of Paraoxonase (Pon1)

Toby B. Cole, University of Washington

12:20-1:40 PM Buffet Lunch, Informal Scientific Interactions
1:40-3:20 PM COMPARATIVE GENOMICS

Chair: Terrence J. Kavanagh, Professor, Department of Environmental & Occupational Health Sciences, University of Washington

1:40 PM Gene expression profiling of normal mammary tissue from rat strains with differential genetic susceptibilities to mammary carcinogenesis

Syed T. Haider, Center for BioArrays, University of Washington

2:00 PM Cell-Type Specific Responses To Chemotherapeutics In Breast Cancer

Melissa A. Troester, University of North Carolina at Chapel Hill

2:20 PM Toxicogenomic profiling in primary hepatocyte culture models from rodents and humans

Curtis J. Omiecinski, The Pennsylvania State University

2:40 PM Genetic Study of C. elegans Innate Immune Response

Alejandro Aballay, Duke University Medical Center

3:00 PM A SNP in NCAM1 shows association with human neural tube defects

Kristen L. Bastress, Duke University Medical Center

3:20-3:40 PM Break
3:40-5:00 PM PREDICTIVE TOXICOLOGY

Chair: Richard S. Paules, Director, Microarray Group and Toxicogenomics Facilitator, NIEHS

3:40 PM Gene Expression Analysis of Mismatch Repair Deficient E. coli Treated with Cisplatin

Jennifer L. Robbins, Massachusetts Institute of Technology

4:10 PM Pcb-Induced Changes In Gene Expression Assayed Across Multiple Cell Types And Pcb Congeners

Christine Kostek Brown, Boston Biomedical Research Institute

4:50 PM Complex Responses To Damaging Agents

Lisiane B. Meira, Massachusetts Institute of Technology

5:00-6:45 PM Poster Session and Social Hour

Adjourn and Transport to Ray’s Boathouse Restaurant

7:30PM Dinner and Keynote Speaker

Inter-disciplinary Research: Translation of Genomics to Reduce Risk
Bill Suk, Director, Center for Risk and Integrated Sciences, DERT, NIEHS

MONDAY, DECEMBER 8, 2003
8:00 – 8:30 AM Continental Breakfast
Mini Symposium: Integration of "Omics" Data
8:30-9:25 AM KEYNOTE: PROTEOMICS

A review of shotgun proteomic methods for discovery based projects.
David Robinson Goodlett, Director Proteomics Facility, Institute for Systems Biology, Seattle

9:25-10:20 AM KEYNOTE: METABOLOMICS

Metabonomics: challenges and opportunities for integrating metabolite profiling in systems biology.
Craig E. Thomas, Head, Lead Optimization Toxicology, Lilly Research Laboratories, Indianapolis

10:20-10:35 AM Break
10:35-11:30 AM KEYNOTE: SYSTEMS BIOLOGY

Querying interaction networks for pathways: a new paradigm (perhaps) for toxicogenomics.
Trey Ideker, Professor of Bioengineering, University of California at San Diego

11:30-12:00 AM PANEL DISCUSSION

(Keynote Speakers, David Eaton, Peter Spencer, Jonathan Freedman)

12:00-1:00 PM Box Lunch
Presentations and Open Dialog with Commercial Suppliers
1:00-1:20 PM From Research to Results: CodeLink Three Dimensional Bioarrays for Gene Expression Analysis

Tamma Kaysser-Kranich, Amersham Biosciences

1:20-1:40 PM Quantitative Analysis of Gene Expression Using Chemiluminescent Detection on Microarrays

Criss Walworth, Applied Biosystems

1:40-2:00 PM Genechip® Microarray Applications In Toxicogenomics

Jacques Retief, Affymetrix

2:00-2:20 PM Using Flexible Inkjet Microarray Manufacturing for Agilent Catalog Microarrays

Erik Bjeldanes, Agilent Technologies

2:20-2:40 PM Break
TRC Business Meeting – Closed Session
2:40-5:00 PM Cooperative Research Program
  • TRC Publication
  • Standardization Experiment 3 (time permitting)
5:00-6:30 PM TRC Steering Committee Meeting

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Last Reviewed: August 23, 2007