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NINDS Announces New Spanish-Language Website
Friday, Dec 7, 2007
Free, accurate information on many neurological disorders is now available on a new Spanish-language website from the National
Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH). The website is available
at espanol.ninds.nih.gov.
Lithium May Offer Relief from Rare but Devastating Neurological DisordersThursday, Aug 2, 2007
Lithium carbonate, a compound commonly used to treat depression, might also provide symptomatic relief for a group of inherited
movement disorders that includes the fatal disease spinocerebellar ataxia type 1 (SCA1).
Therapeutics for Huntington's and Related Diseases Could Pack a One-Two PunchTuesday, Jun 5, 2007
Added to its devastating neurological symptoms, Huntington's disease (HD) carries with it a lesser-known horror. The genetic
mutation that causes the disease can grow larger, causing its symptoms – involuntary movements, dementia, and dramatic personality
changes – to grow worse across generations and even during a single lifetime. New research sheds light on how the mutation
grows and offers hope for locking it down.
Variation in HIV Protein Yields Clues to AIDS-Related DementiaThursday, Feb 8, 2007
In a move that could lead to better treatments for neurological complications of AIDS, researchers have identified a protein
variant in HIV that is associated with brain infection and dementia in people with the disease.
Variation in HIV Protein Yields Clues to AIDS-Related DementiaThursday, Feb 8, 2007
In a move that could lead to better treatments for neurological complications of AIDS, researchers have identified a protein
variant in HIV that is associated with brain infection and dementia in people with the disease.
Study Links Alzheimer's Disease to Abnormal Cell DivisionTuesday, Jan 17, 2006
A new study in mice suggests that Alzheimer's disease (AD) may be triggered when adult neurons try to divide. The finding
helps researchers understand what goes wrong in the disease and may lead to new ways of treating it.
Study Links Progressive Aphasia Syndrome to Prion GeneMonday, Nov 28, 2005
Most people with a rare type of dementia called primary progressive aphasia (PPA) have a specific combination of prion gene
variants, a new study shows. The study is the first to link the prion protein gene to this disorder. The researchers also
looked at the prion protein gene in people with Alzheimer's disease and amyotrophic lateral sclerosis (ALS or Lou Gehrig's
disease) and did not find any association with specific gene variants in those disorders.
Study Links Progressive Aphasia Syndrome to Prion GeneMonday, Nov 28, 2005
Most people with a rare type of dementia called primary progressive aphasia (PPA) have a specific combination of prion gene
variants, a new study shows. The study is the first to link the prion protein gene to this disorder. The researchers also
looked at the prion protein gene in people with Alzheimer's disease and amyotrophic lateral sclerosis (ALS or Lou Gehrig's
disease) and did not find any association with specific gene variants in those disorders.
Study Detects Brain Virus in HIV-Positive PatientsTuesday, May 5, 1992
Scientists at the National Institute of Neurological Disorders and Stroke (NINDS) have identified a potentially fatal virus
in the bloodstream in half of a small group of HIV-positive patients without neurological symptoms, they announced today at
the annual meeting of the American Academy of Neurology in San Diego.
Molecular Fingerprint Predicts HIV-Associated DementiaMonday, Jun 23, 2003
A new study using a cutting edge research technique called "proteomics protein fingerprinting" shows that HIV patients with
dementia have distinct protein patterns in their blood, setting them apart from patients with no symptoms of dementia. The
study suggests a possible way to screen HIV patients for the first signs of cognitive impairment.
Fact Sheet
Discovery may lead to skin tests for Alzheimer's disease; Finding could also point to underlying cause of the disorderFact Sheet
Tuesday, Aug 31, 1993
Scientists at the National Institute of Neurological Disorders and Stroke (NINDS) in Bethesda, MD, and the Burke Medical Research
Institute at Cornell Medical College in White Plains, NY, have discovered physiological differences in the skin cells of those
with Alzheimer's disease (AD), a finding that could lead to a standard battery of skin tests for diagnosing the disease.
Vaccine Reduces Parkinson's Disease Neurodegeneration in MiceWednesday, Jul 28, 2004
For the first time, researchers have shown that an experimental vaccine can reduce the amount of neurodegeneration in a mouse
model for Parkinson's disease. The finding suggests that a similar therapy might eventually be able to slow the devastating
course of Parkinson's disease in humans.
Fact Sheet
Investigators Explore Selective Silencing of Disease GenesFact Sheet
Wednesday, Oct 15, 2003
A new strategy to shut down mutant gene expression in the brain may someday be useful to treat a wide range of hereditary
neurodegenerative diseases, such as Huntington’s, Alzheimer’s, and Parkinson’s diseases.
Fact Sheet
Molecular Fingerprint Predicts HIV-Associated DementiaFact Sheet
Monday, Jun 23, 2003
A new study using a cutting edge research technique called "proteomics protein fingerprinting" shows that HIV patients with
dementia have distinct protein patterns in their blood, setting them apart from patients with no symptoms of dementia. The
study suggests a possible way to screen HIV patients for the first signs of cognitive impairment.
Fact Sheet
Dystonia Protein Linked to Problem Common in Other Neurological DisordersFact Sheet
Monday, Mar 24, 2003
A new study links the protein that is impaired in the movement disorder torsion dystonia to a problem that is common to many
neurological diseases. The finding may point to new treatments for dystonia, Parkinson's disease, and other disorders.
Fact Sheet
Researchers Find Genetic Links for Late-Onset Parkinson's DiseaseFact Sheet
Wednesday, Dec 19, 2001
Recent studies provide strong evidence that genetic factors influence susceptibility to the common, late-onset form of Parkinson's
disease (PD). The findings improve scientists' understanding of how PD develops and may lead to new treatments or even ways
of preventing the disease.
Fact Sheet
NIH Grantees Awarded Nobel Prize in Physiology or Medicine for Brain ResearchFact Sheet
Monday, Oct 9, 2000
Long-time National Institutes of Health grantees Dr. Eric R. Kandel and Dr. Paul Greengard were awarded the 2000 Nobel Prize
in Physiology or Medicine for their discoveries in signal transduction in the nervous system. Together their work has improved
treatments for Parkinson's disease, schizophrenia, and depression and holds promise for the improvement of memory in various
types of dementia.
NINDS Funds Five Specialized Neuroscience Programs at Minority InstitutionsTuesday, Jan 18, 2000
The National Institute of Neurological Disorders and Stroke (NINDS), in collaboration with the National Center for Research
Resources (NCRR) and the Office for Research on Minority Health (ORMH), recently awarded grants to five minority institutions
under a new funding mechanism called Specialized Neuroscience Research Programs at Minority Institutions (SNRP).
Genetics Not Significant to Developing Typical Parkinson's DiseaseTuesday, Jan 26, 1999
Genetic factors do not play a significant role in causing the most common form of Parkinson's disease (PD), according to a
study to be published in the January 27, 1999 issue of the Journal of the American Medical Association. This epidemiological
study, the largest of its kind to investigate the role of genetic or environmental causes of PD, examined 19,842 white male
twins enrolled in a large registry of World War II veteran twins.
Gene for Last Major Form of Batten Disease DiscoveredFriday, Sep 19, 1997
Just two years ago, the origins of the fatal childhood neurological disorders called Batten disease were shrouded in mystery,
and there were few prospects for effective treatment. Now, for the first time, researchers can describe the genetic underpinnings
of all major childhood forms of the disease.
NIH Scientists Identify Gene for Fatal Childhood Disorder, Niemann-Pick Type C: Finding Points to Critical New Steps in Cholesterol
ProcessingThursday, Jul 10, 1997
Bethesda, MD -- After decades of work, scientists at the National Institutes of Health have identified a gene alteration associated
with the fatal childhood cholesterol disorder Niemann-Pick type C (NPC). Learning how the gene functions may lead to the
first effective treatment for the disease and to a fundamental new understanding of how cholesterol is processed in the body.
Scientists Locate Parkinson's GeneThursday, Nov 14, 1996
For the first time, scientists have pinpointed the location of a gene they believe is responsible for some cases of Parkinson's
disease. Their discovery provides strong evidence that a genetic alteration is capable of causing the disease. The study,
published in the November 15 issue of Science,1 sheds light on the mysterious origins of this devastating neurological disease
that affects about 500,000 Americans.
Scientists Identify Gene for Spinocerebellar Ataxia 2Thursday, Oct 31, 1996
Scientists have identified the gene altered in one of the most common hereditary ataxias, spinocerebellar ataxia 2 (SCA2).
The discovery allows improved genetic testing and provides new clues about how genetic mutations cause several neurological
disorders, including Huntington's disease. The findings are reported by three different groups in the November issue of Nature
Genetics.
Protein Marker Found in Transmissible Spongiform Encephalopathies: Finding May Lead to Diagnostic Test for Human, Cattle
DisordersWednesday, Sep 25, 1996
A protein widely distributed in tissues throughout the body, with the highest concentration in the brain, has been shown to
be a specific marker in the spinal fluid of humans and animals infected with transmissible spongiform encephalopathies, scientists
say. This discovery paves the way for the development of an improved test for the diagnosis of Creutzfeldt-Jakob disease
in humans and encephalopathies in animals. The test could enable precise identification of disease in British cattle presently
targeted for slaughter because of suspected infection with bovine spongiform encephalopathy, known as Mad Cow disease.
Clues found for early memory loss in Alzheimer's diseaseThursday, Apr 7, 1994
Scientists at the National Institute of Neurological Disorders and Stroke (NINDS) have discovered that adding a substance
called beta amyloid to normal skin cells causes the cells to exhibit the same type of molecular dysfunction previously demonstrated
in skin cells of patients with Alzheimer's disease (AD). This step may lead to a new explanation of memory loss, one of the
earliest and most common symptoms of the disease.
AIDS Virus Can Infect NeuronsTuesday, Sep 28, 1993
Using modern genetic techniques that can detect single copies of genes inside intact cells, scientists have uncovered the
first conclusive evidence that the AIDS virus (HIV) can infect neurons. And using fetal brain tissue cultures, scientists
have identified key substances that turn on the AIDS virus in the brain.
Discovery may lead to skin tests for Alzheimer's disease; Finding could also point to underlying cause of the disorderTuesday, Aug 31, 1993
Scientists at the National Institute of Neurological Disorders and Stroke (NINDS) in Bethesda, MD, and the Burke Medical Research
Institute at Cornell Medical College in White Plains, NY, have discovered physiological differences in the skin cells of those
with Alzheimer's disease (AD), a finding that could lead to a standard battery of skin tests for diagnosing the disease.
Scientists Link Fatal, Cholesterol-Storage Disorder to Chromosome 18Monday, Mar 1, 1993
Scientists at the National Institute of Neurological Disorders and Stroke (NINDS) have linked a deadly brain disorder, called
Niemann-Pick Type C disease, to a small region of human chromosome 18. These findings, reported in the current issue of Proceedings
of the National Academy of Sciences,* may eventually lead to improved diagnosis and treatment for this inherited disorder
and yield new insight into the metabolism of cholesterol inside the body's cells.
Study Detects Brain Virus in HIV-Positive PatientsTuesday, May 5, 1992
Scientists at the National Institute of Neurological Disorders and Stroke (NINDS) have identified a potentially fatal virus
in the bloodstream in half of a small group of HIV-positive patients without neurological symptoms, they announced today at
the annual meeting of the American Academy of Neurology in San Diego.
NINDS Scientists Isolate Segments Of DNA Sequence That Identify More Than 2,300 Brain GenesWednesday, Feb 12, 1992
Using a novel strategy, scientists from the National Institute of Neurological Disorders and Stroke have isolated segments
of DNA sequence that uniquely identify more than 2,300 brain genes. The recent data, combined with data from 347 segments
sequenced earlier by NINDS scientists, doubles the total number of human genes identified by sequencing, scientists report
in the February 13 issue of Nature.
Creutzfeldt-Jakob Gene Mutation FoundThursday, Aug 30, 1990
Scientists at the National Institute of Neurological Disorders and Stroke (NINDS) have linked three outbreaks of Creutzfeldt-Jakob
disease (CJD) in Europe and Israel to a genetic mutation found in the outbreaks' victims.
National Institute of Neurological Disorders and Stroke
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