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Selected Publications

Spontaneous Mutation & DNA Repair Group

  1. Mackwan R.R., Carver G.T., Kissling, G.E., Drake J.W., Grogan D.W. (2008) The rate and character of spontaneous mutation in Thermus thermophilus. Genetics 180(1):17-25. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18723895) Exit NIEHS
  2. Schultz G.E. Jr., Drake J.W. (2008) Templated mutagenesis in bacteriophage T4 involving imperfect direct or indirect sequence repeats. Genetics 178(2):661-673. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18245334) Exit NIEHS
  3. Drake, J. W. (2007) Too many mutants with multiple mutations. Crit. Rev. Biochem. Mol. Biol. 42: 247-258. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17687667&query_hl=12&itool=pubmed_docsum Exit NIEHS Website
  4. Mackwan, R. R., G. T. Carver, J. W. Drake and D. W. Grogan (2007) An Unusual Pattern of Spontaneous Mutations Recovered in the Halophilic Archaeon Haloferax volcanii. Genetics 176: 697-702. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17194771&query_hl=12&itool=pubmed_docsum Exit NIEHS Website
  5. Drake, J. W. (2006) Chaos and order in spontaneous mutation. Genetics 173: 1-8. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16723419&query_hl=12&itool=pubmed_docsum Exit NIEHS Website
  6. Schultz, G. E., Jr., G. T. Carver and J. W. Drake (2006) A role for replication repair in the genesis of templated mutations. J. Mol. Biol. 4: 963-973. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16574154&query_hl=12&itool=pubmed_docsum Exit NIEHS Website
  7. Drake, J. W., A. Bebenek, G. E. Kissling and S. Peddada (2005) Clusters of mutations from transient hypermutability. Proc. Natl. Acad. Sci. USA 102: 12849-12854. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16118275&query_hl=12&itool=pubmed_docsum Exit NIEHS Website
  8. Bebenek, A., G. T. Carver, F. A. Kadyrov, G. E. Kissling and J. W. Drake (2005) Processivity clamp gp45 and ssDNA-binding-protein gp32 modulate the fidelity of bacteriophage RB69 DNA polymerase in a sequence-specific manner, sometimes enhancing and sometimes compromising accuracy. Genetics 169: 1815-1824. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15695359&query_hl=12&itool=pubmed_docsum Exit NIEHS Website
  9. Kadyrov, F. A., and J. W. Drake (2004) UvsX recombinase and Dda helicase rescue stalled bacteriophage T4 DNA replication forks in vitro. J. Biol. Chem. 279: 279: 35735-35740. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15194689&query_hl=12&itool=pubmed_docsum Exit NIEHS Website
  10. Friedman, R., J. W. Drake and A. L. Hughes (2004) Genome-wide patterns of nucleotide substitution reveal stringent functional constraints on the protein sequences of thermophiles. Genetics 167: 1507-1512. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15280258&query_hl=12&itool=pubmed_docsum Exit NIEHS Website
  11. Kadyrov, F. A., and J. W. Drake (2003) Properties of bacteriophage T4 proteins deficient in replication repair. J. Biol. Chem. 278: 25247-25255. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12697750&query_hl=12&itool=pubmed_docsum Exit NIEHS Website
  12. Bebenek, A., G. T. Carver, H. K. Dressman, F. A. Kadyrov, J. K. Haseman, V. Petrov, W. H. Konigsberg, J. D. Karam and J. W. Drake (2002) Dissecting the fidelity of bacteriophage RB69 DNA polymerase: site-specific modulation of fidelity by polymerase accessory proteins. Genetics 162: 162: 1003-1018. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12454051&query_hl=12&itool=pubmed_docsum Exit NIEHS Website
  13. Malpica, J. M., A. Fraile, I. Moreno, C. I. Obies, J. W. Drake and F. GarcĂ­a-Arenal (2002) The rate and character of spontaneous mutation in an RNA virus. Genetics 162: 1505-1511. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12524327&query_hl=12&itool=pubmed_docsum Exit NIEHS Website
  14. Bebenek, A., H. K. Dressman, G. T. Carver, S. Ng, V. Petrov, G. Yang, W. H. Konigsberg, J. D. Karam and J. W. Drake (2001) Interacting fidelity defects in the replicative DNA polymerase of bacteriophage RB69. J. Biol. Chem. 276: 10387-10397. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11133987&query_hl=12&itool=pubmed_docsum Exit NIEHS Website
  15. Grogan, D. W., G. T. Carver and J. W. Drake (2001) Genetic fidelity under harsh conditions: analysis of spontaneous mutation in the thermoacidophilic archaeon Sulfolobus acidocaldarius. Proc. Natl. Acad. Sci. USA 98: 7928-7933. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11427720&query_hl=12&itool=pubmed_docsum Exit NIEHS Website

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Last Reviewed: January 16, 2009