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Selected Publications

Eukaryotic Transcriptional Regulation Group

2003 – present

  1. Dhasarathy A, Wade PA. (2008) The MBD protein family-Reading an epigenetic mark? Mutation research 647(1-2):39-43. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18692077) Exit NIEHS
  2. Dhasarathy A, Kajita M, Wade PA. (2007) The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor alpha. Molecular endocrinology (Baltimore, Md.) 21(12):2907-2918. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17761946) Exit NIEHS
  3. Chadwick, L.H. and Wade, P.A. (2007) MeCP2: transcriptional repressor or chromatin architectural protein? Current Opin Genet Dev (in press).
  4. Palmer, M.B., Majumder, P., Green, M.R., Wade, P.A., and Boss, J.M. (2007) A 3’ enhancer controls Snail expression in melanoma cells. Cancer Research, in press.
  5. Horton, J.R., Elgar, S.J., Khan, S.I., Zhang, X., Wade, P.A., and Cheng, X. Structure of the SANT domain from the Xenopus chromatin remodeling factor ISWI. Proteins (in press).
  6. Wang, Z., Wade, P., Mandell, K.J., Akyildiz, A., Parkos, C.A., Mrsny, R.J., and Nusrat, A. (2007) Raf1 represses expression of the tight junction protein occludin via activation of the zinc finger transcription factor Slug. Oncogene 26, 1222-1230.
  7. Wade, P.A. and Archer, T.K. (2006) Epigenetics: Environmental instructions for the genome. Environ Health Perspect 114, A140-A141.
  8. Fatemi, M. and Wade, P.A. (2006) MBD family proteins: Reading the epigenetic code. J Cell Sci 119, 3033-3037.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16868031&query_hl=2) Exit NIEHS
  9. Ahn, J.-Y., Liu, X., Liu, Z., Pereira, L., Chen, D., Peng, J., Wade, P.A., Hamburger, A.W., and Ye, K. (2006) Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase. EMBO J 25, 2083-2095.
  10. Wade, P.A. (2005) Switching off Methylated DNA. Nature Genetics 37, 4-5.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15731752&query_hl=26) Exit NIEHS
  11. Ahn, J.-Y., Liu, X., Chen, D., Peng, J., Chan, P.-K., Wade, P.A., and Ye, K. (2005) Nucleophosmin/B23, a nuclear PI(3,4,5) receptor, mediates the anti-apoptotic actions of NGF by inhibiting CAD. Mol Cell 18, 435-445.
  12. Fujita, N., Jaye, D.L., Gigerman, C., Akyildiz, A., Mooney, M.R., Boss, J.M., and Wade, P.A. (2004) MTA3 and the Mi-2/NuRD complex regulate cell fate during B-lymphocyte differentiation. Cell 119, 75-86.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15454082&query_hl=2) Exit NIEHS
  13. Kajita, M., McClinic K.N., and Wade, P.A. (2004) Aberrant expression of the transcription factors Snail and Slug alter the response to genotoxic stress. Mol Cell Biol. 24, 7559-7566.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15314165&query_hl=2) Exit NIEHS
  14. Fujita, N., Kajita, M., Taysavang, P., and Wade, P.A. (2004) Hormonal regulation of MTA3 transcription in breast cancer cells. Mol Endocrinol 18, 2937-2949.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15358836&query_hl=2) Exit NIEHS
  15. Bowen, N.J., Fujita, N., Kajita, M., and Wade, P.A. (2004) Mi-2/NuRD: Multiple complexes for many purposes. Biochim. Biophys. Acta 1677, 52-57.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15020045&query_hl=2) Exit NIEHS
  16. Fujita, N. and Wade, P.A. (2004) Use of bifunctional cross-linking reagents in mapping genomic distribution of chromatin remodeling complexes. Methods 33, 81-85.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15039090&query_hl=2) Exit NIEHS
  17. Wade, P.A. (2004) Dynamic Regulation of DNA methylation coupled transcriptional repression: BDNF regulation by MeCP2. BioEssays 26, 217-220.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14988922&query_hl=2) Exit NIEHS
  18. Bowen, N.J., Palmer, M.B., and Wade, P.A. (2004) Chromosomal regulation by MeCP2: Structural and enzymatic considerations. Cellular and Molecular Life Sciences 61, 2163-2167.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15338046&query_hl=2) Exit NIEHS
  19. Fujita, N. and Wade, P.A. (2004) Nuclear Transfer: Epigenetics pays a visit. Nature Cell Biology 6, 920-922.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15459719&query_hl=2) Exit NIEHS
  20. Fujita, N., Jaye, D.L., Kajita, M., Geigerman, C., Moreno, C., and Wade, P.A. (2003) MTA3, an Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. Cell 113, 207-219.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12705869&query_hl=2) Exit NIEHS
  21. Shimono, Y., Murakami, H., Kawai, K., Wade, P.A., Shimokata, K., and Takahashi, M. (2003) Mi-2β associates with BRG1 and RET finger proteins at the distinct regions with transcriptional activating and repressing abilities. J Biol Chem 278, 51638-51645.
  22. Aoyagi, S., Wade, P.A., Hayes, J.J. (2003) Nucleosome sliding induced by the xMi-2 complex does not occur exclusively via a simple twist-diffusion mechanism. J Biol Chem 278, 30562-30568.
  23. Georgel, P.T., Horowitz-Scherer, R.A., Adkins,N., Woodcock, C.L., Wade, P.A., and Hansen, J.C. (2003) Chromatin compaction by human MeCP2: assembly of novel secondary chromatin structures in the absence of DNA methylation. J Biol Chem 278, 32181-32188.
  24. Fraga, M.F., Ballestar, E., Montoya, G., Taysavang, P., Wade, P.A., Esteller, M. (2003) The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties. Nucleic Acids Res 31, 1765-1774.
  25. Etchegaray, J.P., Lee, C., Wade, P.A,, and Reppert S.M. (2003) Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature 421, 177-182.

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Last Reviewed: December 08, 2008