Selected Publications

Molecular Pathology Group

Genetic Alternations in Animal Models of Cancer

1. Takatoshi, K., Ton, T.T, Lahousse, S.A., Hong, H.L., Wakamatsu, N., Sills, R.C.: K-ras cancer gene mutations in lung tumors from female Swiss (CD-1) mice exposed transplacentally to 3’-azido-3’-deoxythymidine. Environ. Mol. Mutagenesis. In Press, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18800350?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
2. Wei B.H., Edwards, J.B., Hoover, S.B., Sheppard H.W., Reed, L.T., Sills, R.C., Simpson, R.M.: Altered beta-catenin accumulation in hepatocelular carcinomas of diethynitrosamine-exposed rhesus macaques. Toxicologic Pathology. In Press, 2008.
3. Wakamatsu, N., Collins, J.B., Parker, J.S., Tessema, M., Clayton, N.P., Ton, T.V., Hong, H.H., Belinsky, S., Devereux, T.R., Sills ,R.C., Lahoousse, S.A.: Gene expression studies demonstrate that the K-ras/Erk MAP kinase signal transduction pathway and other novel pathways contribute to the pathogenesis of cumene-induced lung tumors. Toxicologic Pathology, 36: 743, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18648096?dopt=Abstract)
4. Hong H.H., Ton T.T., Kim Y., Wakamatsu N., Clayton N.P., Chan P.C., Sills R.C., Lahousse S.A.: Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from B6C3F1 mice exposed to cumene. Tox. Path. 36: 720, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18648094?dopt=Abstract)
5. Wakamatsu, N., Hong, H.L., Devereux, T.R., Sills, R.C.: Overview of the molecular carcinogenesis of mouse lung tumor models of human lung cancer. Tox. Path. 35: 75, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17325975?dopt=Abstract)
6. Hong, H.L., Houle, C.D., Ton, T.T., Sills, R.C.: K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse. Tox. Path. 35: 81, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17325976?dopt=Abstract)
7. Hong, H.H., Dunnick, J., Herbert, R., Devereux, T.R., Kim, Y., Sills, R.C.: Genetic alterations in K-ras and p53 cancer genes in lung neoplasms of Swiss (CD-1) male mice exposed transplacentally to AZT. Environmental and Molecular Mutagenesis. 48: 299, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16395694?dopt=Abstract)
8. Houle, C.D., Ton, T., Clayton, N., Huff, J., Hong, H.L., Sills, R.C.: Frequent p53 and H-ras mutations in benzene- and ethylene oxide-induced mammary carcinomas from B6C3F1 mice. Tox. Path. 34: 752, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17162533?dopt=Abstract)
9. Ton, T., Hong, H.H., Devereux, T.R., Melnick, R.L., Sills, R.C., Kim Y.: Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene. Chem Biol Interactions. 166: 112, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16860786?dopt=Abstract)
10. Kim, Y., Ton, T.V., DeAngello, T., Morgan, K., Devereux, T.R., Anna, C., Collins, J.B., Paules, R.S., Crosby, L.M., Sills, R.C.: Major carcinogenic pathways and genes identified by gene expression analysis of peritoneal mesotheliomas following chemical treatment in F344 rats. Toxicol Appl Pharmacol. 214: 144, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16460773?dopt=Abstract)
11. Lambertini, L., Surin, K., Ton, T.V., Clayton, N., Dunnick, J.K., Kim, Y., Hong, H.H., Devereux, T.R., Sills, R.C.: Analysis of p53 tumor suppressor gene, H-ras protooncogene and proliferating cell nuclear antigen (PCNA) in squamous cell carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen (8-MOP) and UVA radiation (PUVA therapy). Tox. Path. 33: 292, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/15902973?dopt=Abstract)
12. Kim, Y., Hong, H.H., Lachat, Y., Clayton, N.P., Devereux, T.R., Melnick, R.L., Hegi, M.E., Sills, R.C.: Genetic alterations in brain tumors following 1,3-butadiene exposure in B6C3F1 mice. Tox. Path. 33: 307, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/15814359?dopt=Abstract)
13. Iida, M., Anna, C.H., Holliday, W.M., Collins, J.B., Cunningham, M.L., Sills, R.C., Devereux, T.R.: Unique patterns of gene expression changes in liver after treatment of mice for 2 weeks with different known carcinogens and non-carcinogens. Carcinogenesis. 26: 689, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/15618236?dopt=Abstract)
14. Sills, R.C., Hong, H.L., Flake, G., Moomaw, C., Clayton, N., Boorman, G.A., Dunnick, J., Devereux, T.R.: O-Nitrotoluene-induced large intestinal tumors in B6C3F1 mice model human colon cancer in their molecular pathogenesis. Carcinogenesis, 25: 605, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/14688030?dopt=Abstract)

Neuropathology Research in Animal Models

1. Bolon, B., Anthony D.C., Butt, M., Dorman, D., Green, M.V., Little, P., Valentine, W.M., Weinstock, D., Yan, J., Sills, R.C.:“Current Pathology Techniques” symposium review: advances and issues in neuropathology. Toxicologic Pathology. In Press, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18812578?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
2. Moser, V., Phillips, P.M., McDaniel, K.L., Sills, R.C.: Neurotoxicological evaluation of two disinfection by-products, bromodichloromethane and dibromoacetonitrile in rats. Toxicology. 230: 137, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17157428?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
3. Herr, D.W., Graff, J.E., Moser, V.C., Crofton, K.M., Little, P.B., Morgan, D.L., Sills, R.C.: Inhalational exposure to carbonyl sulfide (COS) produces altered brainstem auditory (BAER) and somatosensory (SEP) evoked potentials in F344 rats. Toxicological Sciences. 95: 118, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17079700?dopt=Abstract)
4. Cesta, M.F., Mozzachio, P., Little, P.B., Olby, N.J., Sills, R.C., Brown T.T.: Neuronal ceriod lipofuscinosis in a vietnamese pot-bellied pig (Sus Scrofa). Vet Pathol. 43: 556, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16847000?dopt=Abstract)
5. Sills, R.C., Harry, G.J., Valentine, W.M., Morgan, D.L.: Interdisciplinary neurotoxicity inhalation studies: Carbon disulfide and carbonyl sulfide research in F344 rats. Toxicol Appl Pharmacol, 207 (2 Suppl): 245, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16002115?dopt=Abstract)
6. Sills, R.C., Morgan, D.L., Herr, D.W., Little, P.B., George, N.M., Ton, T.V., Love, N.E., Maronpot, R.R., Johnson, G.A.: Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats. Tox. Path. 32: 501, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/15603534?dopt=Abstract)
7. Morgan, D.L., Little, P.B., Herr, D.W., Moser, V.C., Collins, B., Herbert, R., Johnson, G.A., Maronpot, R.R., Harry, G.J., Sills, R.C.: Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeks. Toxicol Appl Pharmacol. 200: 131, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/15476866?dopt=Abstract)
8. Moser, V.C., Phillips, P.M., Levine, A.B., McDaniel, K.L., Sills, R.C., Jortner, B.S., Butt, M.T.: Neurotoxicity produced by dibromoacetic acid in drinking water of rats. Toxicol Sci. 79: 112, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17157428?dopt=Abstract)
9. Sills, R.C., Valentine, W.M., Moser, V., Graham, D.G., Morgan, D.L.: Characterization of carbon disulfide neurotoxicity in C57BL6 mice: Behavioral, morphological and molecular effects. Tox. Path., 28: 142, 2000. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/10669001?dopt=Abstract)
10. Sills, R.C., Hailey, J.R., Neal, J., Boorman, G.A., Haseman, J.K., Melnick, R.L.: Examination of low incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program Studies. Tox. Path., 27: 589, 1999. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/10528639?dopt=Abstract)

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