|
Report of an Expert Consultation on the Uses of Nucleic Acid
Amplification Tests for the Diagnosis of Tuberculosis
Return to Contents
Research Needs
- Conduct operational research for developing, evaluating,
and selecting the most effective and efficient NAA testing
algorithms for routine use and for specific scenarios.
- Develop and evaluate tests suitable for use with
non-respiratory specimens (e.g., cerebrospinal fluid, gastric
aspirates, or biopsies).
- Develop and evaluate tests that will enhance the
diagnosis of TB in children.
- Develop and evaluate optimal specimen collection,
transport, and processing methods.
- Determine the influences of specimen quality and quantity
on NAA test performance.
- Characterize the ability of NAA tests to detect M.
tuberculosis bacteria in mixed infections.
- Develop, evaluate, and deploy NAA tests with improved
performance and ease-of-use and features that include
- point-of-care testing, turnaround times of <2 hours
- automatable, minimal hands-on time
- minimal specimen processing required
- closed system to minimize end-product contamination
concerns
- internal controls for inhibitors
- increased sensitivity, perhaps through using target
capture technologies
- quality-assured reagents for use in the test reactions
and for use as controls
- Conduct regulatory quality trials for any new NAA test
aimed at obtaining FDA approval.
Last Modified: 11/25/2008
Last Reviewed: 05/18/2008 Content Source: Division of Tuberculosis Elimination
National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention
|
|
Back to Top of Page
If you would like to order any of the DTBE publications please visit the online order form.
You will need Adobe Acrobat Reader v5.0 or higher to read pages that are in PDF format. Download the Adobe Acrobat Reader.
If you have difficulty accessing any material on the DTBE Web site because of a disability, please contact us
in writing or via telephone and we will work with you to make the information available.
Division of Tuberculosis Elimination
Attn: Content Manager, DTBE Web site
Centers for Disease Control and Prevention
1600 Clifton Rd., NE Mailstop E-10
Atlanta, GA 30333
CDC-INFO at (1-800) 232-4636
TTY: 1 (888) 232-6348
E-mail: cdcinfo@cdc.gov
Home | Site Map
| Contact Us
Accessibility
| Privacy Policy Notice |
FOIA
| USA.gov
CDC Home |
Search |
Health Topics A-Z
Centers for Disease Control & Prevention
National Center for HIV/AIDS,
Viral Hepatitis, STD, and TB Prevention
Division of Tuberculosis Elimination
Please send comments/suggestions/requests to: CDCINFO@cdc.gov
|