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nabilone A synthetic cannabinoid and dibenzopyrane derivative with anti-emetic activity. Although the mechanism of action has not been fully elucidated yet, it has been suggested that nabilone is a highly selective and strong agonist for the cannabinoid receptors CB1 and CB2, both of which are coupled to Gi/o proteins. The CB1 receptors are expressed predominantly in central and peripheral neurons and receptor stimulation has been implicated in the reduction of chemotherapy-induced nausea. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
![](https://webarchive.library.unt.edu/eot2008/20090115024225im_/http://www.cancer.gov/images/spacer.gif)
Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090115024225im_/http://www.cancer.gov/images/spacer.gif) | Cpd 109514 | | ![](https://webarchive.library.unt.edu/eot2008/20090115024225im_/http://www.cancer.gov/images/spacer.gif) | Foreign brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090115024225im_/http://www.cancer.gov/images/spacer.gif) | Cesamet | | ![](https://webarchive.library.unt.edu/eot2008/20090115024225im_/http://www.cancer.gov/images/spacer.gif) |
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