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nanoparticle albumin-bound docetaxel A nanoparticle albumin-bound formulation of the taxane docetaxel with antineoplastic activity. Docetaxel is a semi-synthetic, second-generation taxane derived from a compound found in the European yew tree Taxus baccata. Docetaxel binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell-cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. This nanoparticle albumin-bound formulation solubilizes docetaxel without the use of the nonionic solubilizer Cremophor ELP, permitting the administration of larger doses of docetaxel while avoiding Cremophor ELP-associated toxicity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090115024631im_/http://www.cancer.gov/images/spacer.gif) | nab-docetaxel | | ![](https://webarchive.library.unt.edu/eot2008/20090115024631im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090115024631im_/http://www.cancer.gov/images/spacer.gif) | ABI-008 | | ![](https://webarchive.library.unt.edu/eot2008/20090115024631im_/http://www.cancer.gov/images/spacer.gif) |
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