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ifosfamide A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20090115054921im_/http://www.cancer.gov/images/spacer.gif) | Ifomide Iphosphamid iphosphamide Isoendoxan Iso-Endoxan isophosphamide Naxamide | | ![](https://webarchive.library.unt.edu/eot2008/20090115054921im_/http://www.cancer.gov/images/spacer.gif) | US brand names: | ![](https://webarchive.library.unt.edu/eot2008/20090115054921im_/http://www.cancer.gov/images/spacer.gif) | Cyfos Ifex Ifosfamidum | | ![](https://webarchive.library.unt.edu/eot2008/20090115054921im_/http://www.cancer.gov/images/spacer.gif) | Foreign brand names: | ![](https://webarchive.library.unt.edu/eot2008/20090115054921im_/http://www.cancer.gov/images/spacer.gif) | Holoxan Holoxane IFO-Cell Ifolem Ifomida Ifoxan Mitoxana Tronoxal | | ![](https://webarchive.library.unt.edu/eot2008/20090115054921im_/http://www.cancer.gov/images/spacer.gif) | Abbreviations: | ![](https://webarchive.library.unt.edu/eot2008/20090115054921im_/http://www.cancer.gov/images/spacer.gif) | IFF IFO IFX IPP | | ![](https://webarchive.library.unt.edu/eot2008/20090115054921im_/http://www.cancer.gov/images/spacer.gif) | Code names: | ![](https://webarchive.library.unt.edu/eot2008/20090115054921im_/http://www.cancer.gov/images/spacer.gif) | Asta Z-4942 MJF-9325 Z-4942 | | ![](https://webarchive.library.unt.edu/eot2008/20090115054921im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure names: | ![](https://webarchive.library.unt.edu/eot2008/20090115054921im_/http://www.cancer.gov/images/spacer.gif) | - 2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine
- 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide
- N,3-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
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