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ketoconazole
A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| US brand names: | | Nizoral
Xolegel | | | | Foreign brand names: | | Fungarest
Fungoral
Ketoderm
Ketoisdin
Orifungal M
Panfungol | | | | Abbreviation: | | KCZ | | | | Code name: | | R-41400 | | | | Chemical structure name: | | cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine | | |
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