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thioguanine
A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| US brand names: | | Tabloid
Tabloid brand thioguanine
Tioguanine | | | | Foreign brand names: | | Lanvis
Tioguanin | | | | Abbreviations: | | 6-TG
TG | | | | Code names: | | BW 5071
Wellcome U3B
WR-1141
X 27 | | | | Chemical structure names: | | - 2-Amino 6MP
- 2-Amino-1,7-dihydro-6H-purine-6-thione
- 2-Amino-6-mercaptopurine
- 2-Amino-6-purinethiol
- 2-Aminopurin-6-thiol
- 2-Aminopurine-6(1H)-thione
- 2-Aminopurine-6-thiol
- 6 Mercaptoguanine
- 6 Thioguanine
- 6H-Purine-6-thione, 2-amino-1,7-dihydro- (9CI)
- 6-Mercapto-2-aminopurine
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