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dasatinib![Patient Information Patient Information](https://webarchive.library.unt.edu/eot2008/20090114231118im_/http://www.cancer.gov/images/btn-patient-info.gif) An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090114231118im_/http://www.cancer.gov/images/spacer.gif) | Sprycel | | ![](https://webarchive.library.unt.edu/eot2008/20090114231118im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090114231118im_/http://www.cancer.gov/images/spacer.gif) | BMS-354825 | | ![](https://webarchive.library.unt.edu/eot2008/20090114231118im_/http://www.cancer.gov/images/spacer.gif) |
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