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VermontClinical Research Resources Links ON THIS PAGE: University of Vermont General Clinical Research Center Grant No. M01 RR00109 Special Assays, Services, or TestsD2O (deuterium) dilution technique for estimating total body water and body composition Doubly labeled water Immunoassays: C-peptide, cortisol, glucagon, insulin, prolactin, GH, cotinine, nicotine, leptin Isolation of peripheral blood mononuclear cells Mass spectrometry assays including stable isotopomer analysis of CO2, body water, amino acids, sugars, and fatty acids Online analyses of whole blood glucose, lactate, plasma CO2 Special Resources, Instruments, or Services Bicycle ergometers Human physiology lab, exercise testing, body
composition analysis Major Areas of InvestigationCardiac Disease: Cardiac function in heart failure; cardiac rehabilitation. Clinical Pharmacology: Phase I and II drug trials. Gastroenterology: Regional enteritis; immune studies of chronic active hepatitis; effect of diet on colonic mucosa. Gynecology: Estrogen metabolism in postmenopausal women; prostaglandin synthetase inhibitors; modulating role of body composition on reproductive hormones; effect of estrogen on cardiac function. Metabolism: Obesity; hypoglycemia; diabetes mellitus; exercise; genetic studies in multiple endocrine neoplasia; catecholamine metabolism; regulation of energy expenditure; ketoacid effects on amino acid metabolism in insulin-dependent diabetes mellitus; protein metabolism-regulation of protein synthesis and degradation by hormones and substrates; interactions between diabetes and thromboses. Neurology: Therapeutic intervention in idiopathic chronic polyneuropathy; DNA damage in muscular dystrophy, polymyositis, amyotrophic lateral sclerosis, Alzheimer's and Parkinson's diseases. Nutrition: Pathophysiology of weight gain; obesity; diet-induced thermogenesis; dietary fiber; nutrition support; effect of dietary fiber on estrogen metabolism; effects of vitamin K1 in women of childbearing age; low-calorie versus low-fat diets; effects of tryptophan depletion on behavior. Oncology: Clinical trials of chemotherapeutic agents and immunotherapy; intraperitoneal IL-2 and lymphokine-activated killer cells in recurrent ovarian carcinoma; lymphatic scintigraphy. Pediatrics: Hormonal mechanisms of pubertal growth; relation of age-related decline in growth hormone to muscle loss and fat accumulation; treatment of obesity with growth hormone; testing for prediabetes. Psychiatry: Bulimia and anorexia nervosa: treatment comparison; stimulant and alcohol interactions; mecamylamine model of dementia; effect of nicotine administration on cognitive functions in Alzheimer's disease; genetic basis of aggression in children; substance abuse; drug discrimination. Surgery: Subcutaneous heparin versus oral warfarin in patients undergoing unilateral elective knee or hip replacement surgery. Contact InformationFor information about this GCRC and how to access its resources, please contact: Administrative Director Program Director Principal Investigator Associate Program Director Associate Program Director Research Subject Advocate GCRC Advisory Committee Chairperson Biochemistry Core Laboratory Manager Mass Spectrometry Core Laboratory Director Physiology Core Laboratory Coordinator Nurse Manager Bionutrition Research Manager Biostatistician Informatics Core Manager |
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National Institutes of Health (NIH) Bethesda, Maryland 20892 |
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