National Toxicology Program

CASRN: 100-42-5

Formula: C8 H8

Synonyms/Common Names:

• ETHENYLBENZENE (9CI)
• PHENYLETHYLENE
• VINYLBENZENE

Known Uses:

IN MANUFACTURE OF PLASTICS, SYNTHETIC RUBBER, RESINS. INSULATOR. USED IN CONSTRUCTION MATERIALS AND BOATS. CHEMICAL INTERMEDIATE. FLAVORING AGENT. (TDB)

Short-Term Toxicity

• 14-Day (Gavage)  (C02200A) Completed 
  • NTIS No. PB300977  (Peer Review 10/25/1978)
    Citation: Bioassay of Styrene for Possible Carcinogenicity (CAS No.100-42-5)
  • Rats: F344/N; Mice: B6C3F1
• 2-WEEK (Inhalation)  (C02200B) Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 30, 100, 300, 1000, 0R 2000 PPM (5/S/S)
• 13-Week (Gavage)  (C02200A) Completed 
  • NTIS No. PB300977  (Peer Review 10/25/1978)
    Citation: Bioassay of Styrene for Possible Carcinogenicity (CAS No.100-42-5)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,681,3160, M: 0,147,681 MG/KG/10 PER GROUP
• 13-WEEK (Inhalation)  (C02200B) Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 125, 250, 500, 1000, OR 1500 PPM M: 0, 62.5, 125, 250, OR 500 PPM

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C02200A) Report Complete 
  • TR-185 (NTIS No. PB300977)  (Peer Review 10/25/1978)
    Bioassay of Styrene for Possible Carcinogenicity (CAS No.100-42-5)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Equivocal 
  • Female Mice Negative 
  • Dose: R: 0,500,1000,2000, M: 0,150,300 MG/KG/50 PER GROUP

Special Studies

• Mechanisms (Inhalation)  (S0333) Completed 
  • Citation: MORGAN ET AL. STYRENE INHALATION TOXICITY STUDIES IN MICE. 1 HEPATOTOXICITY IN B6C3F1 MICE, FUND & APPL TOXICOL 20:325-335, 1993. 2. SEX DIFFERENCES IN SUSCEPTIBILITY OF B6C3F1 MICE, FUND & APPL TOXICOL 21:317-325, 1993. 3. STRAIN DIFFERENCES IN SUSCEPTIBILITY, FUND & APPL TOXICOL 21:326-333, 1993.
  • M/F Mice: B6C3F1; M/F Mice: C57BL/6; M/F Mice: Swiss; M/F Mice
  • Dose: 125, 250 OR 500 PPM

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (987609) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Micronucleus  (A71890) Completed 
  • Male Not Tested 
  • Female Not Tested 
• Micronucleus  (A82713) Completed 
  • Male Positive 
• Salmonella (NCI)  (N-9246) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Negative 
• Salmonella  (173117) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Negative