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| The following information (Health Effects, Handling/Disposal, and Ingredients) is taken from the product label and/or the Material Safety Data Sheet (MSDS) prepared by the manufacturer. The National Library of Medicine does not test products nor does it evaluate information from the product label or the MSDS.
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Health Effects
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From MSDS
IMMEDIATE CONCERNS:
- CAUSES EYE IRRITATION
- HARMFUL IF SWALLOWED
- DO NOT GET IN EYES, ON SKIN, OR ON CLOTHING
- AVOID BREATHING VAPOR OR SPRAY MIST
- KEEP OUT OF REACH OF CHILDREN
POTENTIAL HEALTH EFFECTS
EYES: This substance is slightly irritating to the eyes. Eye contact may include discomfort, tearing, swelling, redness, and blurred vision.
SKIN: The skin irritation potential of this substance has not been determined. However, it may be a moderate skin irritant so contact with the skin could cause prolonged (days) injury to the affected area. This may include discomfort, redness, swelling, and possibly blistering. The systemic toxicity of this substance has not been determined. However, it should be practically non-toxic to internal organs if it gets on the skin.
INGESTION: The oral toxicity of this substance has not been determined. However, it may be slightly toxic to internal organs if swallowed. The degree of injury will depend on the amount absorbed from the gut. This product contains a petroleum distillate. Due to the low viscosity of petroleum distillates, they can get directly into the lungs through aspiration either during swallowing or vomiting of the product.
INHALATION: The systemic toxicity of this substance has not been determined. However, it should be practically non-toxic to internal organs if inhaled.
TARGET ORGANS: Chlorpyrifos is an inhibitor of the cholinesterase enzyme, found in nervous tissue, red blood cells, and plasma.
COMMENTS HEALTH: Depending upon the extent and degree of overexposure to the product, signs and symptoms of cholinesterase inhibition can result following either ingestion, skin contact or inhalation routes of exposure. Signs and symptoms of cholinesterase inhibition can also result from either acute (one time), subchronic (repeated short-term) and chronic (daily life-time) overexposure to the product.
Signs and symptoms of cholinesterase inhibition usually occur within 12 hours following overexposure. These effects may include, but may not be limited to, headache, dizziness, weakness, nausea, vomiting, diarrhea, constriction of the pupil of the eye, blurred or dark vision, excessive salivation or nasal discharge, profuse sweating and abdominal cramps. Incontinence, unconsciousness, convulsions and breathing difficulties are indicative of severe poisoning. In untreated severe poisoning, death is due to respiratory failure or cardiac arrest.
This product also contains a petroleum distillate. Depending upon the degree of overexposure, the systemic toxicity of the product may be of less concern than the potential clinical complications that can result from aspiration of the petroleum distillate into the lungs if the product is either swallowed or vomited.
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From MSDS
Signs and symptoms of cholinesterase inhibition can also result from either acute (one time), subchronic (repeated short-term) and chronic (daily life-time) overexposure to the product.
Signs and symptoms of cholinesterase inhibition usually occur within 12 hours following overexposure. These effects may include, but may not be limited to, headache, dizziness, weakness, nausea, vomiting, diarrhea, constriction of the pupil of the eye, blurred or dark vision, excessive salivation or nasal discharge, profuse sweating and abdominal cramps. Incontinence, unconsciousness, convulsions and breathing difficulties are indicative of severe poisoning. In untreated severe poisoning, death is due to respiratory failure or cardiac arrest.
SUBCHRONIC: Results of subchronic oral toxicity studies in rats, mice, dogs and monkeys indicated that inhibition of plasma cholinesterase was the most sensitive indicator of overexposure followed by red blood cell and brain cholinesterase. Results of several rat 1-6 month oral toxicity studies revealed a no-observable-effect-level (NOEL) in the range of 0.1 mg/kg/day.
NEUROTOXICITY: Chlorpyrifos is not considered to produce organophosphate induced delayed neuropathy. However, certain human anecdotal cases, involving the ingestion of lethal doses of chlorpyrifos, survived because of immediate aggressive antidotal therapy and respiratory support, later developed temporary signs of neuropathy.
TERATOGENICITY: Chlorpyrifos in not considered to be a teratogen (a substance that causes birth defects).
REPRODUCTIVE TOXIN: Chlorpyrifos is not considered to be a reproductive toxin.
MUTAGENICITY: Chlorpyrifos is not considered to be a mutagen.
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From MSDS
CARCINOGENICITY COMMENTS: Chlorpyrifos is not considered to be a carcinogen. There were no carcinogenic findings in any of the chronic animal toxicology investigations. The signs of systemic toxicity were primarily due to inhibition of cholinesterase.
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From MSDS
EYES: Flush eyes immediately with fresh water for at least 15 minutes while holding the eyelids open. Remove contact lenses if worn. Call a physician.
SKIN: If on skin, remove contaminated clothing, wash skin with plenty of soap and water. Wash contaminated clothing before reuse.
INGESTION: If swallowed, immediately telephone a poison control center, emergency treatment center or a physician for advice. DO NOT make person vomit unless directed to do so by medical personnel. If medical advice cannot be obtained, then immediately take person and product container, with label, to an emergency treatment center.
INHALATION: If respiratory discomfort or irritation occurs, move the person to fresh air. See a doctor if discomfort or irritation continues.
NOTES TO PHYSICIAN: Ingestion of this product or subsequent vomiting can result in aspiration of light hydrocarbon liquid which can cause pneumonitis. This material contains a cholinesterase inhibitor. Measurement of blood cholinesterase activity may be useful in monitoring exposure. If signs of cholinesterase inhibition appear, atropine sulfate is antidotal. 2-PAM (PROTOPAM) is also antidotal and may be used in conjunction with atropine but should not be used alone.
ADDITIONAL INFORMATION: Medical Information: Call day or night, 1-800-454-2333 OR 1-800-457-2022.
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| 0 |
0 = Minimal; 1 = Slight; 2 = Moderate; 3 = Serious; 4 = Severe;
N = No information provided by manufacturer; * = Chronic Health Hazard |
| 2001-06-26 |
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Handling/Disposal
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From MSDS
GENERAL PROCEDURES: Keep pesticide in original container. Do not put concentrate or dilute into food or drink containers. Avoid contamination of feed, foodstuffs and domestic water supplies. Store in a cool dry place, preferably in a locked storage area. Do not store diluted spray. Store above freezing. Handle concentrate in a ventilated area. Keep container closed.
ECOTOXICOLOGICAL INFORMATION: This material is toxic to fish, birds and other wildlife. Do not apply directly to water. Do not contaminate water by cleaning of equipment or disposal of wastes.
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From MSDS
The Solaris Group is committed to responsible environmental practices and recommends that all of the product be used up, carefully following all label directions and precautions.
If necessary to dispose of partially filled product container, then securely wrap it in several layers of newspaper and discard in trash.
EMPTY CONTAINER: Do not reuse container. Rinse thoroughly before discarding in trash.
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Ingredients from MSDS/Label
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