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anamorelin hydrochloride
The orally bioavailable hydrochloride salt of a synthetic, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play a direct role in cancer-related loss of appetite. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Code name: | | RC-1291 | | | | Chemical structure names: | | - (3R)-1-{(2R)-2-[(2-amino-2-methylpropanoyl)amino]-3-(indol-3-yl)propanoyl}-3-benzyl-N,N',N'-trimethylpiperidine-3-carbohydrazide hydrochloride
- 3-piperidinecarboxylic acid, 1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-, trimethylhydrazide, monohydrochloride, (3R)-
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