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anti-CD33 monoclonal antibody-DM4 conjugate AVE9633
An immunoconjugate consisting of the humanized monoclonal antibody huMy9-6 conjugated to the cytotoxic maytansinoid DM4 with potential antineoplastic activity. The monoclonal antibody portion of anti-CD33 monoclonal antibody-DM4 conjugate AVE9633 specifically binds to the cell surface antigen CD33 expressed on myeloid leukemia cells; upon internalization, the DM4 moiety is released, binds tubulin, and disrupts microtubule assembly/disassembly dynamics, resulting in the inhibition of cell division and cell growth in myeloid leukemia cells that express CD33. CD33 is expressed on normal non-pluripotent hematopoietic stem cells as well as on myeloid leukemia cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Code name: | | AVE9633 | | |
| Previous: | anti-CD200 monoclonal antibody ALXN6000, anti-CD22 immunotoxin CAT-8015, anti-CD3 immunotoxin A-dmDT390-bisFv(UCHT1), anti-CD30 monoclonal antibody MDX-1401, anti-CD30 monoclonal antibody XmAb2513 | | Next: | anti-CD37 single-chain polypeptide TRU-016, anti-CD38 monoclonal antibody, anti-CD45 monoclonal antibody, anti-CD45 monoclonal antibody AHN-12, anti-CD70 monoclonal antibody MDX-1411 |
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