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amonafide dihydrochloride The dihydrochloride salt of amonafide, an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20090115015600im_/http://www.cancer.gov/images/spacer.gif) | amonafide amonafide hydrochloride benzisoquinolinedione nafidimide | | ![](https://webarchive.library.unt.edu/eot2008/20090115015600im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090115015600im_/http://www.cancer.gov/images/spacer.gif) | Quinamed | | ![](https://webarchive.library.unt.edu/eot2008/20090115015600im_/http://www.cancer.gov/images/spacer.gif) | Abbreviations: | ![](https://webarchive.library.unt.edu/eot2008/20090115015600im_/http://www.cancer.gov/images/spacer.gif) | AMON BIDA | | ![](https://webarchive.library.unt.edu/eot2008/20090115015600im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090115015600im_/http://www.cancer.gov/images/spacer.gif) | M-FA-142 | | ![](https://webarchive.library.unt.edu/eot2008/20090115015600im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20090115015600im_/http://www.cancer.gov/images/spacer.gif) | 1H-benz(de)isoquinoline-1,3(2H)-dione, 5-amino-2-(2-(dimethylamino)ethyl) | | ![](https://webarchive.library.unt.edu/eot2008/20090115015600im_/http://www.cancer.gov/images/spacer.gif) |
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