 |
|
aminopeptidase inhibitor CHR-2797
A proprietary orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. Aminopeptidase inhibitor CHR-2797 is converted intracellularly into a poorly membrane-permeable active metabolite (CHR-79888) which inhibits the M1 family of aminopeptidases, particularly puromycin-sensitive aminopeptidase (PuSA), and leukotriene A4 (LTA4) hydrolase; inhibition of these aminopeptidases in tumor cells may result in amino acid deprivation, inhibition of protein synthesis due to a decrease in the intracellular free amino acid pool, an increase in the level of the proapoptotic protein Noxa, and cell death. Noxa is a member of the BH3 (Bcl-2 homology 3)-only subgroup of the proapoptotic Bcl-2 (B-cell CLL/lymphoma 2) protein family. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Code name: | | CHR-2797 | | |
| Previous: | Amfebutamone, amifostine trihydrate, aminobenzoate potassium, aminocamptothecin, aminolevulinic acid | | Next: | aminopterin, aminothiadiazole, amiodarone hydrochloride, AML mRNA plus lysate loaded autologous dendritic cell vaccine, Ammoidin |
|
|
