Primate Resources
National Primate Research Centers
Monkey Research Resources
Chimpanzee Research Resources
Chimpanzee Management Program
Specific-Pathogen-Free Macaque Resources
Nonhuman Primate Research Reagents
Center Access Criteria and Procedures
The National Primate Research Center (NPRC) facilities
and resources enable NPRC staff scientists and
investigators from the host institution and others
across the country to collaborate on their research
projects. The centers' specialized resources are
intended to support investigators who receive their
primary research project funding from NIH, but they
also may be used by investigators who are funded by
other federal, state, and local agencies, as well as by
research foundations and the private sector. Together
the NPRCs have more than 26,000 animals representing
more than 20 species of nonhuman primates, mostly
macaques.
Each NPRC has a Visiting Scientist Program that offers
advanced training and research in nonhuman primate
biology. Collaborative arrangements between
investigators and center scientific staff are
encouraged and can be developed on studies related to
major human diseases, subject to the availability of
resources and center staff time. Nonhuman primate blood
samples, organs, and biological fluids are available
through the NPRCs. The following standardized criteria
and procedures have been implemented at each NPRC to
facilitate utilization of center resources:
Access Criteria
-
The nature and scope of the proposed research must
be best conducted with nonhuman primates and be
compatible with available center resources.
-
The proposed research must have high scientific
merit as determined by peer review.
-
NIHfunded research takes precedence over
research activities funded by other sources.
-
Grants must contain appropriate budgets for the NPRC
portion, including animal per diem costs.
-
Availability of NPRC resources, including animals,
space, research services and support, and special
requirements—such as biosafety
facilities— are also limiting factors that
must be considered by the investigator.
-
Because of potential contamination (e.g., viral,
microbial), movement of animals into or out of the
NPRC facilities is not allowed. Thus, the proposed
research using live animals must use NPRC animals,
and the research must be conducted at the NPRC.
Access Procedures
-
An initial research proposal must be submitted by
the researcher to the NPRC prior to submitting an
application for funding. The director then consults
with the research services, veterinary, and colony
management staff members at the center to assess
resource availability and project feasibility. (Note
that special requests or conditions regarding
animals of certain age, gender, weight, or other
stipulations affect the NPRC's capability to
meet the researcher's needs.)
-
When resource availability and project feasibility
have been established, the NPRC staff will provide
budget information to the researcher regarding the
center costs to be included in the formal research
proposal.
-
The scientific merit of the proposal must then be
evaluated through the NIH peer review process or
through a similar process at other agencies.
However, small pilot projects with other funding
sources may be considered. In the latter case, the
peer review is conducted by the NPRC Research
Advisory Committee.
-
In addition to the scientific peer review, a
protocol approved by the Institutional Animal Care
and Use Committees (IACUC) at both the
investigator's institution and the NPRC must be
in place. Protocols must also be established to
address biosafety concerns.
-
When the investigator has received notification of
funding, the NPRC director should be advised
immediately so that the resources at the center may
be reserved for the funded proposal.
-
Biological materials such as blood samples, organ
tissues, and biological fluids can be obtained by
contacting the directors and staff of the NPRCs.
All publications resulting from research conducted at
or with NPRC resources must bear an appropriate
acknowledgment of NCRR support.
Inquiries
For additional information about the Visiting Scientist
Program and resources available at a specific center,
including applying to utilize a center's resources,
contact the center director or appropriate contact
person listed in this directory.
California National Primate Research
Center
Research Emphasis/Objectives
The California National Primate Research Center (NPRC)
is a research unit of the University of California,
Davis. Its mission is to provide interdisciplinary
programs in biomedical research on significant human
health-related problems in which nonhuman primates are
the most appropriate model for the research.
Current Research
The center has a diverse program of research utilizing
nonhuman primates. Research projects encompass many
aspects of biology and medicine, including AIDS and
other infectious diseases; reproductive issues such as
those associated with conception, pregnancy, and fetal
growth and development; neurodegenerative conditions
such as Alzheimer's disease; nutritional
deficiencies; pulmonary disorders such as asthma,
emphysema, and other chronic obstructive lung diseases;
xenotransplantation; cell- and gene-based therapies;
acute and chronic stress; temperament and biobehavioral
organization; social relationships; neurobiology;
cognitive function; and behavioral development.
Services Provided
Research units include brain, mind, and behavior;
reproductive sciences; respiratory diseases; and
virology and immunology; as well as an affiliate
research program, core services, and the primate
services and medicine division. Research opportunities
are available for investigators from national and
international institutions, as well as scientists
within the UC Davis research community. The NPRC is
also home to the Center for Fetal Monkey Gene Transfer
for Heart, Lung, and Blood Diseases under the direction
of Alice Tarantal, Ph.D.
To Outside Investigators
Specimens
Organs and tissues are provided when available; other
biological samples are provided on special request.
Shipping, collecting, and processing costs are charged
to the requestor.
To Collaborating Scientists
Scientists wishing to conduct research at the center
must have their projects reviewed and approved by the
center director, research advisory committee, and
campus animal care review committee. The center's
services are available to collaborating scientists on a
fee-for-service basis. Services include:
Core Science
Endocrine Core
Immunology Core
Inhalation Exposure Core
Computational Imaging Core
Pathogen Detection Core
Behavioral Assessment Core Contact Core Directors at
530-752-0447.
Primate Medicine
Preventive medicine and epidemiologic evaluation,
surgery, radiology, therapeutics, specialized medical
procedures.
Diagnostic Pathology and Clinical Laboratory Services
Bacteriology, biochemistry, hematology, parasitology,
pathology, virology.
Animals
Center breeding colony: cynomolgus macaque ( Macaca
fascicularis ), rhesus macaque ( M.
mulatta ). Center research colony: Callicebus
moloch, M. mulatta, M. fascicularis .
Contact Information
California National Primate Research
Center
University of California, Davis
Davis, CA 95616
Web site: www.cnprc.ucdavis.edu![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: P51
RR000169
Center Director and Contact
Dallas M. Hyde, Ph.D.
530-752-0420; Fax: 530-754-6228
E-mail: dmhyde@ucdavis.edu
Additional Contact
Jenny Short
530-752-7169
Principal Investigator
Barry M. Klein, Ph.D.
The center is located on a 300-acre tract three
miles from the main campus of the University of
California, Davis. The university administers the
center and provides its academic setting.
New England National Primate
Research Center
Research Emphasis/Objectives
The New England National Primate Research Center
support studies of HIV/SIV/AIDS, oncogenic
herpesviruses, other infectious diseases, behavioral
biology, neurodegenerative diseases, neurochemistry,
brain imaging, and neuropharmacology.
Current Research
Use of simian immunodeficiency virus (SIV) as a model
for AIDS in rhesus monkeys, host and viral determinants
of AIDS pathogenesis, strategies for vaccine
development, immune-based therapeutic strategies,
pathogenesis of opportunistic infections. Elucidation
of spontaneous diseases of nonhuman primates and
development of new models for comparable human
diseases. Neurobiology and behavioral pharmacology of
cocaine abuse with emphasis on mechanisms of action,
behavioral effects, and treatment. Use of
1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)
model for Parkinson's disease, to develop imaging
agents for chronic neurologic disorders, to monitor
disease progression and effectiveness of therapeutic
strategies. Drug discovery and development for central
nervous system disorders.
Services Provided
To Outside Investigators
Specimens
Tissue specimens, organs, blood, skeletal structures,
viral specimens, etc. Animals for approved research
projects are provided from breeding colonies or other
sources as required. Costs are normally assumed by the
individual requesting the specimens.
To Collaborating Scientists
Scientists wishing to conduct research at the center
must have projects reviewed and approved by the
center's animal allocation committee. A brochure
explaining the collaborative research program is
available from the center. Most services are provided
on a fee-for-service basis. They include veterinary
services, animals and animal care, surgical and
radiographic services, timed mating, biocontainment,
pathology services, and professional and technical
expertise.
Animals
Colonies of rhesus macaque ( Macaca mulatta ),
cynomolgus macaque ( M. fascicularis ), common
marmoset ( Callithrix jacchus ), and squirrel
monkey ( Saimiri sciureus ). Other species can
be obtained. Animals with exceptional characteristics
(specific-pathogen-free, timed pregnancy, surgically
altered, etc.) can be made available if needed.
Contact Information
New England National Primate
Research Center
One Pine Hill Drive
P.O. Box 9102
Southborough, MA 01772-9102
Web site: www.hms.harvard.edu/nerprc![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: P51
RR000168
Center Director and Contact
Ronald C. Desrosiers, Ph.D.
508-624-8002; Fax: 508-460-0612
E-mail: ronald_desrosiers@hms.harvard.edu
Additional Contact
James T. Wortham, M.P.A.
508-624-8003
E-mail: james_wortham@hms.harvard.edu
Principal Investigator
Joseph B. Martin, M.D., Ph.D.
The center is located on 135 acres in Southborough,
Massachusetts, about 30 miles from Boston. Harvard Medical
School administers the center and provides its academic
setting.
Oregon National Primate Research
Center
Research Emphasis/Objectives
The Oregon National Primate Research Center supports
studies in the reproductive sciences, neuroscience,
pathobiology, and immunology.
Current Research
Control of folliculogenesis and the corpus luteum,
factors that control sperm motility and maturation,
hormonal control of parturition, steroid receptors in
primate reproductive tract and brain tissues,
implantation, in vitro fertilization, and embryonic
stem cells. Neurological processes in regeneration of
neural tissue, interactions between neural and immune
systems, factors controlling differentiation and growth
of neurons and glia, degenerative diseases,
developmental neurobiology, and control of reproduction
and of food intake. Pathobiology and immunology, human
and animal models related to AIDS and other viral
infections.
Services Provided
To Outside Investigators
Tissue specimens, organs, etc., when available. Costs
are normally assumed by the requestor.
To Collaborating Scientists
Scientists wishing to conduct research must have their
projects approved by the Institutional Animal Care and
Use Committee and the research advisory subcommittee.
Most services are provided on a fee-for-service basis.
They include:
Medical Services
Physiological data, surgery, ultrasound, DEXA scanning.
Colony Operations
Primates, guinea pigs, mice, hamsters, rats, rabbits.
Pathology
Necropsies, tissue distribution, consultation.
Microscopy and Image Analysis Services
Confocal microscopy and stereology.
Data Processing
Comprehensive animal information system, consultation
and support on statistical processing, extensive
radioimmunoassay support.
Library
8,300 books, 15,250 bound journals, 200 journal
subscriptions, MEDLARS searching services, PriMed
database, Internet.
Endocrine Services Laboratory
Steroid and protein hormone radioimmunoassays.
Medical Illustrations and Photography
Animals
Japanese macaque ( Macaca fuscata ), rhesus
macaque ( M. mulatta ), pigtailed macaque (
M. nemestrina ); includes an outdoor troop of
about 300 M. fuscata and a colony of 3,800
M. mulatta .
Molecular Biology Core
DNA synthesis and sequencing, cDNA probes, real-time
PCR, consultation.
Cell Culture Core
Maintenance of cell lines, media preparation.
Morphology Core
Tissue embedding and sectioning, immunohistochemistry,
in situ hybridization.
Assisted Reproductive Technologies Core
Procedures related to in vitro fertilization, nuclear
transfer, intracytoplasmic sperm injection, culture
media, gamete preservation.
Electrophysiology Core
Provides electrophysiology recordings from neurons in
brain slices, from cells in tissue explants, and from
cultured cells that can be used to determine
experimentally induced changes in the electrical
properties of cells.
Contact Information
Oregon National Primate Research
Center
505 N.W. 185th Avenue
Beaverton, OR 97006
Web site: onprc.ohsu.edu![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: P51
RR000163
Center Director and Contact
Nancy L. Haigwood, Ph.D.
503-690-5500; Fax: 503-690-5569
E-mail: HaigwooN@ohsu.edu
Additional Contact
P. Michael Conn, Ph.D.
503-690-5297; Fax: 503-690-5569
E-mail: connm@ohsu.edu
Principal Investigator
Joseph Robertson, M.D.
The center is located on the 247-acre Oregon Health
Sciences University West campus 12 miles from downtown
Portland. OHSU administers the center and provides its
academic setting.
Southwest National Primate
Research Center
Research Emphasis/Objectives
The Southwest National Primate Research Center (NPRC)
supports studies of nonhuman primate models of human
diseases, including common chronic diseases and
infectious diseases and the effects that genetics and
the environment have on physiological processes and
disease susceptibility.
Current Research
Genetics
Genetic and environmental bases for susceptibility to
atherosclerosis, hypertension, osteoporosis, obesity,
and infectious diseases; construction of baboon and
rhesus gene maps; genomic screening for disease-related
genes; genetic management strategies for research
colonies; development of new genetic analytic
strategies and software.
Infectious Diseases
AIDS; hepatitis B, C, and E; herpes B and other
herpesviruses; Chagas disease; emerging viral diseases;
fundamental research and vaccine; and drug testing.
Neonatal Diseases
Bronchopulmonary dysplasia and chronic lung disease of
infancy.
Physiology
Control of ingestive behavior, dietary effects on blood
pressure, brain imaging, lipid metabolism, gene
therapy.
Pathobiology
Spontaneous diseases and experimental models of
diseases.
Behavior
Impact of enrichment strategies on behavior and
well-being, genetic and endocrine effects on maternal
behavior.
Services Provided
To Outside Investigators
The NPRC encourages the use of its resources by
investigators from the national and international
biomedical research communities. The NPRC is also
available for collaborative research initiatives
involving center staff and outside investigators. In
general, expenses are assumed by the initiating
investigator, and collaborative research efforts are
covered by grants acquired collaboratively.
Specimens
Banked serum, tissue, and DNA samples; fresh blood,
serum, plasma, tissues, and organs.
Animals
Baboon ( Papio ) species, chimpanzees (
Pan troglodytes ), rhesus macaques (
Macaca mulatta ), miscellaneous primate
species, as required for specific research purposes.
Veterinary Technical Services
Timed pregnancies, tether, radiography, sonography,
endoscopy, experimental surgery, experimental diets,
nursery, behavioral assessment.
Pathology
Necropsies, clinical chemistry, hematology, histology,
bacteriology, virology, parasitology.
Data Services
Colony database system, genetic analysis software,
genetic typing services.
Contact Information
Southwest National Primate
Research Center
Southwest Foundation for Biomedical Research
Post Office Box 760549
San Antonio, TX 78245-0549
Web site: www.snprc.org![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: P51 RR013986
Center Director
John L. VandeBerg, Ph.D.
E-mail: jlv@darwin.sfbr.org
Principal Investigator
John C. Kerr, J.D.
The center is located on the 397-acre campus of the
Southwest Foundation for Biomedical Research,
approximately 12 miles from downtown San Antonio and 7
miles from the University of Texas Health Science Center
at San Antonio. The Southwest Foundation administers the
center.
Tulane National Primate Research
Center
Research Emphasis/Objectives
The Tulane National Primate Research Center is heavily focused on infectious disease research and also has a significant program in gene therapy that capitalizes on a unique colony of macaques with Krabbe disease.
Current Research
The major areas of infectious disease research at the Center are currently AIDS, Lyme disease, and biodefense-related agents, with additional programs involving tuberculosis, microsporidiosis, and malaria. The AIDS-related research is quite diverse, covering pathogenesis, vaccine development, microbicides, and the origins of AIDS. These are multidisciplinary studies involving investigators in numerous Divisions at the TNPRC and collaborators outside the Center. The gene therapy program involves both traditional viral-vector-mediated gene transfer as well as nonhuman primate mesenchymal and embryonic stem cells. For more information, visit: www.tnprc.tulane.edu
Services Provided - To Outside Invetigators
Specimens: Tissue specimens, blood, and other bodily fluids are provided when available. Collection, processing, and shipping costs are normally assumed by the requestor.
Services Provided - To Collaborating Scientists
The TNPRC provides highly integrated clinical and laboratory support for studies using nonhuman primates. This includes a full-time staff of clinical veterinarians and technicians and core services commonly used for infectious disease and gene therapy research including: 1) Diagnostic Parasitology; 2) Vector-Borne Diseases (maintains arthropods that are important for the study of vector-borne diseases); 3) DNA Microarray and Gene Expression; 4) Anatomic Pathology; 5) Clinical Pathology; 6) Molecular Pathology; 7) Confocal Microscopy and Image Analysis; 8) Flow Cytometry; 9) Cellular Immunology; 10) Virus Characterization, Isolation, and Production; 11) Pathogen Detection and Quantification; 12) Infectious Disease Aerobiology; 13) Genetics and Genome Banking; 14) Vector Development and Production; and 15) Nonhuman Primate Stem Cell Production. For more information, visit www.tnprc.tulane.edu/research_resou.html
.
Animals
Rhesus macaques (Macaca mulatta) of both Indian and Chinese origin are available. Other species can be obtained. Most of the rhesus macaques are specific-pathogen free (B virus, SIV, SRV, and STLV1 negative).
Contact Information
Tulane National Primate Research
Center
18703 Three Rivers Road
Covington, LA 70433
Web site: www.tnprc.tulane.edu![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: P51 RR000164
Center Director and Contact
Andrew A. Lackner, D.V.M., Ph.D., Dipl. A.C.V.P.
985-871-6201; Fax: 985-871-6569
E-mail: info@tpc.tulane.edu
Additional Contact
Mike W. Aertker, M.S.E., M.B.A.
985-871-6200
E-mail: aertker@tulane.edu
Principal Investigator
Benjamin P. Sachs, M.B., B.S., DPH, FACOG
The Center is part of the Tulane University Health Sciences Center along with the School of Medicine and School of Public Health & Tropical Medicine and is located on 500 acres near Covington, Louisiana, 35 miles from the main campus.
Washington National Primate
Research Center
Research Emphasis/Objectives
The Washington National Primate Research Center is
committed to facilitation of nonhuman primate-related
research through collaborative efforts of core and
affiliate scientists. Current biomedical research
projects emphasize neurological sciences, animal
models, AIDS, virology, immunogenetics, cardiovascular
function, developmental biology, and endocrinology and
metabolism.
Current Research
Core Staff
Primate neuroscience, neural control of limb movement,
vestibular and oculomotor interactions, neural
mechanisms of vision, molecular structure of neuronal
membranes, animal model development, virology, viral
pathogenesis, vaccine development, therapeutic
evaluation, genetic regulation of B cell function,
primate major histocompatibility complex, viral
translation, intracellular signaling, transplantation,
gene therapy, and immunology.
Affiliated Staff
Neurological Sciences
Structure and development of monkey visual cortex,
auditory physiology, retinal development, basal ganglia
function.
Animal Models
AIDS model systems, enteric pathogens, antiviral drugs,
reproductive health, venereal disease, chlamydia,
chancroid, fetal alcohol syndrome, parkinsonism,
experimental allergic encephalomyelitis, systemic
candidiasis.
Cardiovascular Disease and Function
Arterial smooth muscle cells in atherosclerosis,
evaluating blood compatibility of biomaterials, fetal
hemoglobin synthesis.
Developmental Biology
Hyaline membrane disease, respiratory distress
syndrome, visual development, effect of epileptic drugs
on development, cognitive development.
Endocrinology and Metabolism Research
Reproductive physiology, regulation of glucagon, role
of somatostatin in physiology and control of
somatostatin secretion, methanol effects, methylmercury
effects, parenteral nutrition, bone loss and gain,
diabetes endocrine research.
Transplantation and Prosthesis Development
Bone marrow transplantation, neurotransplantation,
cochlear prosthetics, arterial graft development, stem
cell transplantation, pancreatic transplantation.
Services Provided
Affiliate Scientists/Outside Investigators
The NPRC is committed to providing complete access to
center resources for the research community to
facilitate all aspects of nonhuman primate-related
research. The center provides substantial assistance
for collaborative research projects based at the
center, including scientific and technical assistance
with protocol development, grant submission, data
collection and interpretation, and manuscript
preparation. A computer database of more than 80,000
bibliographic records (1985 to present) of scientific
literature on nonhuman primates is available for lease
on PC-compatible computer systems. This database
includes full citation and indexing information.
Primate Information Center
Develops indexes of comprehensive, worldwide
bibliographic information regarding biomedical research
on nonhuman primates. Provides published and custom
bibliographies.
Primate Resource Referral Service
(formerly Primate Supply Information Clearinghouse)
Provides communication links—by telephone and
through semimonthly publication of the New Listings
Bulletin —between U.S. scientists in need of
primates or tissues and institutions that can meet
their needs. A registry of primate colonies and special
services is being developed. This service is further
described elsewhere in this Directory, and
at pin.primate.wisc.edu/idp/idp/entry/463
Tissue Distribution Program (TDP)
Provides samples of blood and all major tissues, either
fresh, fixed, or frozen for shipment to investigators
throughout the United States.
Pathology
Provides complete pathology services including gross
necropsy, biopsy, histologic evaluation, special
diagnostic staining, and immunohistochemical and in
situ hybridization studies.
Scientific Illustration and Editing
Neurohistology
Immunologic Typing
Primate Colony Division
Primate health care, surgical procedures, imaging
facilities, genetic characterization, clinical
laboratory, round-the-clock nursery care, computerized
genealogic and clinical records, psychological
well-being, preventive medicine.
Biostructure Technology Laboratory
Bioengineering
Instrumentation development, computer programming.
Animals
Cynomolgus macaque ( Macaca fascicularis ),
rhesus monkey ( M. mulatta ), pigtailed
macaque ( M. nemestrina ), yellow baboon (
Papio cynocephalus ).
Collections
A broad variety of collections are archived
encompassing developmental and physiologic data for the
nonhuman primate.
Contact Information
Washington National Primate
Research Center
University of Washington
I-421 Health Sciences
Box 357330
Seattle, WA 98195-7330
Web site: www.wanprc.org/WaNPRC![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: P51
RR000166
Center Director and Contact
David M. Anderson, D.V.M.
206-543-1430; Fax: 206-616-6771
E-mail: directorsoffice@bart.rprc.washington.edu
Tissue Distribution
206-543-6999
E-mail: necropsy@bart.NPRC.washington.edu
Principal Investigator
Sidney D. Nelson, Ph.D.
The center is located in the Warren G. Magnuson
Health Sciences Center of the University of Washington and
at the Western Facility Annex in Seattle.
Wisconsin National Primate Research
Center
Research Emphasis/Objectives
The WNPRC's mission is to increase our understanding of basic primate biology and to improve human health and quality of life through research. To accomplish this, the WNPRC:
- Helps discover treatments, preventions and cures for human disease.
- Generates new knowledge of primate biology, from the molecular and whole animal levels to the understanding of primate ecosystems.
- Facilitates research progress by providing expertise, resources and training to scientists worldwide.
- Collects primate information and disseminates to the research community and to the public.
2008 Quick Facts:
- Personnel: The WNPRC supports research by more than 250 core and affiliate scientists from the UW-Madison, across the U.S. and around the world. Many graduate students and post-doctoral trainees also conduct research through the Center.
- Funding: $91 million including core and affiliate scientists' total funding. Of that, $38.5 million supporting subprojects using Primate Center resources. Of that, $4.2 million in non-federal funding, primarily foundations and industry.
- Colony: 1,411 animals: 1,106 rhesus macaques, 260 common marmosets, 45 cynomolgus macaques.
- Publications: 119 published and in press journal articles citing the WNPRC.
Current Research
The WNPRC supports three areas of major emphasis and a diverse affiliate program.
Aging and Metabolic Diseases
- Effects of caloric restriction on aging
- Obesity
- Diabetes mellitus
- Osteoporosis
- Ocular aging (glaucoma, presbyopia)
- Neurodegeneration
- Gene expression profiling
- Parkinson's Disease
Immunogenetics and Virology
- Simian immunodeficiency virus
- HIV vaccines
- Simian immunodeficiency virus
- MHC-defined animals
- Cytotoxic T-cells
- Molecular MHC analysis
Reproduction and Development
- Embryonic stem cell biology
- Fertility regulation
- Embryonic differentiation
- Maternal-fetal health
- Reproductive neuroendocrinology
- Polycystic ovarian syndrome
- Endometriosis
- Reproductive tract gene therapy
Services Provided
To Outside Investigators
Researchers interested in conducting research through
the WNPRC and using one of the below services or resources
should first contact our Centralized Protocol Implementation Unit (CPI)
.
CPI integrates and utilizes research service and animal service personnel and their talents to make research programs function in a precise and efficient manner. This integration serves as a gateway for the use of the NPRC and all its service units in research projects for both local and extramural principal investigators.
Research Services:
- Assay Services
- Genetics
- Immunology
- Virology
Research Resources:
- Aging Resource
- Stem Cell Resource
Animal Services:
- Behavioral Management Unit
- Colony Management Unit
- Compliance and Training Unit
- Veterinary Services Unit
- Pathology Services (tissue specimens, organs, other biological materials.)
To Collaborating Scientists
The center actively encourages researchers from the Midwest region and as well as national and international to use its facilities and services and to conduct collaborative studies. Scientists wishing to conduct research must have their projects reviewed and approved by the center director and advisory committees and have independent funding to cover costs. Most of the center's services are available on a fee-for-service basis.
Contact Information
Wisconsin National Primate Research
Center
1220 Capitol Court
Madison, WI 53715-1299
Web site: www.primate.wisc.edu![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: P51
RR000167
Center Director and Contact
Joseph W. Kemnitz, Ph.D.
608-263-3500; Fax: 608-265-2067
E-mail: kemnitz@primate.wisc.edu
Additional Contacts
Jordana Lenon
Public Information and Outreach
608-263-7024
jlenon@primate.wisc.edu
Ray Hamel, M.L.S.
Library and Information Services
608-263-3512
E-mail: hamel@primate.wisc.edu
refdesk@primate.wisc.edu
Principal Investigator
Martin T. Cadwallader, Ph.D.
The center has approximately 120,000 square feet of laboratory, animal, office, and related support space on and near the University of Wisconsin-Madison campus. The UW-Madison Graduate School provides center's administrative support and academic setting.
Yerkes National Primate Research
Center
Research Emphasis/Objectives
The Yerkes National Primate Research Center conducts
biomedical and biobehavioral research to improve the
health and well-being of human and nonhuman primates.
Current Research
Microbiology and Immunology
Primate models for research on AIDS pathogenesis,
treatment, and vaccines; and for other infectious
diseases including malaria.
Neuroscience
Molecular, cellular, and behavioral studies of drugs of
abuse, especially cocaine; cognitive neuroscience and
brain function.
Psychobiology
Endocrine and behavioral studies of primates living in
complex social groups.
Visual Science
Developmental studies of visual function.
Services Provided
To Outside Investigators
Research proposals by investigators from other
institutions are encouraged. Proposals should be
submitted for review by the research advisory committee
to ensure that resources are available. All proposals
are reviewed by the Institutional Animal Care and Use
Committee. Services available to outside investigators
at approved rates include veterinary medicine,
pathology, and biomedical engineering.
Animals
Rhesus macaque ( Macaca mulatta ), pigtailed
macaque ( M. nemestrina ), cynomolgus macaque
( M. fascicularis ), sooty mangabey (
Cercocebus atys ), baboon ( Papio )
species, squirrel monkey ( Saimiri sciureus ),
chimpanzees ( Pan troglodytes ), tufted brown
capuchins ( Cebus apella ).
Service Cores
Brain imaging, DNA microarray, molecular pathology,
virology, and radioimmunoassay.
Contact Information
Yerkes National Primate Research
Center
Emory University
954 North Gatewood Road, N.E.
Atlanta, GA 30322
Web site: www.yerkes.emory.edu![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: P51
RR000165
Center Director and Contact
Stuart Zola, Ph.D.
404-727-7707; Fax: 404-727-0623
E-mail: szola@rmy.emory.edu
Principal Investigator
Michael M. E. Johns, M.D.
Center facilities include the Main Station on 25
acres of the Emory University campus in Atlanta and the
117-acre Field Station for psychobiology research in
nearby Lawrenceville.
Baboon Research Resources
Research Emphasis/Objectives
The Baboon Research Resource conducts multidisciplinary
studies on captive baboons and provides a resource of
laboratory-born and laboratory-reared baboons for
NIH-sponsored research programs. Additional objectives
are to: maintain and provide available research
facilities accredited by the Association for Assessment
and Accreditation of Laboratory Animal Care
International; serve as a ready source of baboons (
Papio spp. ) of mixed ages and sex for use in
biomedical and behavioral sciences; and provide
professional staff necessary to support
investigators' research needs.
Current Research
Current research activities involve characterizing the
endogenous microorganisms of the conventional research
baboon, improving methods for production of baboons in
a captive environment, developing a
specific-pathogen-free colony of baboons, developing
vaccines, and testing genetic diversity among the
baboon breeding population.
Services Provided
To Outside Investigators
The mission of the Oklahoma University Health Sciences
Center (OUHSC) Baboon Research Resource is to support
biomedical and behavioral research requiring the baboon
as the animal model. The resource supports research
investigators at the OUHSC and also serves as a
national resource by supporting numerous investigators
located at institutions across the United States. This
resource enables NIH-funded investigators to purchase
baboons for their research programs, subcontract with
the resource to conduct the study on location at the
OUHSC, or lease the baboons for conducting their
studies and then return the baboons to the breeding
colony. Together with the Oklahoma State University
College of Veterinary Medicine, the Oklahoma State
University Center for Health Sciences, and the Texas
Tech University Health Sciences Center, the resource
continues to further develop and improve the usefulness
of the baboon as an animal model.
To Collaborating Scientists
Individuals interested in collaborative studies must
provide a protocol to the principal investigator of the
Baboon Research Resource. Approval of collaborative
projects depends on the relevance of the proposed
project to the objectives of the Baboon Research
Resource, with preference given to NIH-funded studies.
Complete animal husbandry, veterinary medical care,
technical assistance, and pathology services are
available to investigators who have approval from the
principal investigator to use resource colony animals.
Animals
Adult, infant, and juvenile baboons are available.
Contact Information
Baboon Research Resources
University of Oklahoma Health Sciences Center
Division of Animal Resources
940 S. L. Young Boulevard, BMSB 203
Oklahoma City, OK 73190
Grant No.: P40 RR012317
Principal Investigator and Contact
Gary L. White, D.V.M., M.M.S.
405-271-5185; Fax: 405-271-2660
E-mail: gary-white@ouhsc.edu
Additional Contact
Richard W. Eberle, Ph.D.
405-744-8169; Fax: 405-744-5275
E-mail: reberle@okstate.edu
Caribbean Primate Research Center
Program
Research Emphasis/Objectives
Cayo Santiago
Short- and long-term studies of social and sexual
behavior, population genetics, demography, reproductive
biology, psychopharmacology, functional morphological
and spontaneous diseases (arthritis, osteoporosis,
adult-onset macular degeneration, glaucoma, diabetes,
obesity, hypertension), and parasitoses of rhesus
monkeys maintained under seminatural conditions. Colony
size: 900.
Sabana Seca Field Station
Headquarters of the Caribbean Primate Research Center
(CPRC), specific-pathogen-free (SPF) rhesus breeding
colony and biomedical research on spontaneous diseases
(see above), reproductive biology and embryology,
social behavior, endocrinology, medical genetics,
vaccine development, and husbandry of Cayo
Santiago-derived rhesus macaques maintained under a
variety of housing configurations (individual cages,
pens, and large corrals). Colony size: 800.
Laboratory for Primate Morphology and Genetics
(formerly known as CPRC museum)
Anthropological and biomedical osteological research on
2,500 complete skeletons from 10 species of nonhuman
primates, including more than 1,000 from Cayo Santiago
rhesus monkeys of known identity, age, sex, matriline,
and parity, and 175 skeletons from patas monkeys.
Virology Laboratories
Research on simian immunodeficiency virus (SIV, as a
model for AIDS in rhesus monkeys) and on strategies for
the development of vaccines against SIV and dengue
viruses. This BL2/3 fully equipped laboratory also
supports the SPF grants by performing serological
testing of herpes, STLV-1, SRV, and SIV in rhesus
macaques.
Services Provided
To Collaborating Scientists
CPRC welcomes collaborative research with established
behavioral and biomedical investigators and encourages
the use of its animal and osteological resources for
dissertation research. Investigators are charged modest
use fees for access to the animals, computerized
database, and office space. All proposals receive
rigorous peer review and are judged on scientific
merit, feasibility, and potential overlap with ongoing
studies. Protocols using live monkeys must be approved
by the Institutional Animal Care and Use Committee
(IACUC) of the home institution, as well as the
University of Puerto Rico Medical Sciences Campus
IACUC.
Contact Information
Caribbean Primate Research Center
Program
University of Puerto Rico Medical Sciences Campus
P.O. Box 1053
Sabana Seca, PR 00952-1053
Web site: ucm.rcm.upr.edu/cprc.html![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: P40 RR003640
Principal Investigator and Contact
Edmundo N. Kraiselburd, Ph.D.
787-764-4325; Fax: 787-764-4325
E-mail: ekraiselburd@rcm.upr.edu
Mailing Address
Unit of Comparative Medicine
Office B-315
University of Puerto Rico School of Medicine
Medical Sciences Campus
P.O. Box 365067
San Juan, PR 00936-5067
Development of a
Specific-Pathogen-Free Baboon Colony
Research Emphasis/Objectives
The baboon has long been used in biomedical research
and for certain applications has considerable
advantages over other primate species. Despite their
widespread use in research, there is currently an acute
shortage of baboons available for use. As is well
appreciated for macaques, viruses constituting the
normal flora of research animals can have a
considerable effect on research results and their
validity. Baboons are known to harbor analogs of many
of the herpesviruses and retroviruses known to infect
humans and other primates. Despite many years of
successful breeding of baboons by various institutions,
no colonies of specific-pathogen-free (SPF) baboons
exist that are free of even one specific virus. The
center is developing the beginning of a self-sustaining
colony of baboons free of all known herpesviruses, four
retroviruses, and SV40.
Current Research
To accomplish this goal, the center has
established—in collaboration with
co-investigators and consultants—serological and
PCR tests for each of the 11 target viruses. These
baboon viruses include six herpesviruses (analogs of
human HSV, VZV, CMV, HHV6, EBV, and HHV8), four
retroviruses (simian foamy virus, SRV/D, SIV, and
STLV), and SV40. Twenty-four infant baboons are being
recruited into the SPF program in each of the first
five years, for a final total of at least 66 SPF
baboons. All infants will be repeatedly tested for each
of the target viruses. At one month of age, larger
social groups of 4-6 SPF animals are formed. Beginning
at 2-3 years of age, SPF animals will be integrated
into larger socially compatible groups. These groups
will eventually mature into breeding harems of SPF
animals. This approach provides infants with
age-matched companions for socialization during their
early period of development, minimizes opportunities
for transmission of viruses to the infants from adult
animals, and allows for the simultaneous elimination of
many different viruses from SPF animals.
Services Provided
When the program is fully developed, the goal is to
provide healthy, behaviorally normal, SPF baboons that
are free of all known herpesviruses, four retroviruses,
and SV40.
Contact Information
Development of a
Specific-Pathogen-Free Baboon Colony
University of Oklahoma Health Sciences Center
BMSB 203
940 S. L. Young Boulevard
Oklahoma City, OK 73190
Grant No.: R24 RR016556
Principal Investigator
Gary L. White, D.V.M.
405-271-5185; Fax: 405-271-2660
E-mail: gary-white@ouhsc.edu
Owl Monkey Breeding and Research
Resource
Research Emphasis/Objectives
Research objectives are to carry out multidisciplinary
studies of reproduction in owl monkeys (Aotus spp.), to
search for models relevant to human health, and to
provide a resource of laboratory-born and -reared
animals for NIH-sponsored research programs.
Current Research
Research projects aim to characterize factors that
influence captive reproduction, with emphasis on
developing methods to improve reproductive potential.
Additional studies aim to optimize the usefulness of
owl monkeys in malaria research. A multidisciplinary
approach—including behavioral science,
reproductive endocrinology, medical primatology,
pathology, and genetics—is used to meet research
goals.
Services Provided
To Outside Investigators
Tissues and body fluids are available. Such specimens
are provided on a priority basis to NIH-sponsored
research studies that are related to the objectives of
this project. Costs of packaging and shipping are
negotiated on an individual basis, to be determined by
the nature of the collaboration.
To Collaborating Scientists
Individuals interested in collaborative studies must
provide a protocol to the principal investigator.
Approval of collaborative projects depends on the
relevance of the proposed project to the objectives of
the ongoing research effort. Complete animal husbandry,
medical care, and pathology services are available
without charge to investigators who have received
approval from the principal investigator to use
resource colony animals.
Animals
The breeding colony currently contains approximately
300 owl monkeys of varying ages. Some offspring and
reproductive culls are available.
Core Staff
Investigators conducting studies of medical
primatology, reproductive endocrinology, data
management, primate management and husbandry, primate
behavioral psychology, veterinary pathology, and
genetics are included within the research team.
Guest Investigators and Graduate Students
Guest investigators and graduate students interested in
studies of factors influencing reproduction of owl
monkeys and their usefulness in studies of human
malaria are invited to send letters of interest. These
letters will be considered based on the relevance of
the applicant's interests to the ongoing research
effort and the availability of resources to meet the
needs of the guest investigator.
Contact Information
Owl Monkey Breeding and Research
Resource
Center for Neotropical Primate Research Resources
College of Medicine
University of South Alabama
Mobile, AL 36688
Web site: www.CNPRR.org![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: R24
RR20052
Principal Investigator and Contact
Christian R. Abee, D.V.M.
251-460-6239; Fax: 251-460-7783
E-mail: cabee@mdandeerson.org
Squirrel Monkey Breeding and
Research Resource
Research Emphasis/Objectives
Research objectives are to carry out multidisciplinary
studies of reproduction in squirrel monkeys, to search
for models relevant to human health, and to provide a
resource of laboratory-born and -reared animals for
NIH-sponsored research programs.
Current Research
Characterizing factors that influence captive
reproduction with emphasis on developing methods to
improve reproductive potential. A multidisciplinary
approach—including behavioral studies,
reproductive endocrinology, medical primatology, and
genetics—is ongoing
Services Provided
To Outside Investigators
Tissues and body fluids are available. Such specimens
are provided on a priority basis to NIH-sponsored
research studies that are related to the objectives of
this project. Costs of packaging and shipping are
negotiated on an individual basis to be determined by
the nature of the collaboration.
To Collaborating Scientists
Individuals interested in collaborative studies must
provide a protocol to the principal investigator.
Approval of collaborative projects depends on the
relevance of the proposed project to the objectives of
the ongoing research effort. Complete animal husbandry,
medical care, and pathology services are available
without charge to investigators who have received
approval from the principal investigator to use
resource colony animals.
Animals
The breeding colony currently contains approximately
450 squirrel monkeys of varying ages. Some offspring
and reproductive culls are available.
Core Staff
Investigators conducting studies of medical
primatology, reproductive endocrinology, data
management, primate management and husbandry, primate
behavioral psychology, and genetics.
Guest Investigators and Graduate Students
Guest investigators and graduate students interested in
studies of factors influencing reproduction of squirrel
monkeys in captivity are invited to send letters of
interest. These letters will be considered based on the
relevance of the applicant's interests to the
ongoing research effort and the availability of
resources to meet the needs of the guest investigator.
Contact Information
Squirrel Monkey Breeding and
Research Resource
Center for Neotropical Primate Research and
Resources
College of Medicine
University of South Alabama
Mobile, AL 36688
Web site: www.cnprr.org![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: P40
RR001254
Principal Investigator and Contact
Christian R. Abee, D.V.M.
251-460-6239; Fax: 251-460-7783
E-mail: cabee@mdanderson.org
Vervet Research Colony
Research Emphasis/Objectives
The colony emphasizes development of the vervet as an alternative to the rhesus monkey for biomedical research applications. The objectives are to provide SPF animals, husbandry information, access to the pedigreed and genotyped colony for research manipulations, and access to the repository for hypothesis testing and pilot data generation.
Current Research
Current research includes assessment of: 1) genetic, neurobiological, and behavioral correlates of obesity, insulin resistance, diabetes, osteoporosis, and osteoarthritis; 2) genetic, developmental, and neurobiological influences on traits related to vulnerability for psychopathology; and 3) social, endocrine, and dietary effects on pregnancy outcomes and individual development across the lifespan.
Services Provided
This resource will provide approximately 100 animals per year for biomedical research, including some selected for particular traits (e.g., old age, insulin resistance, and impulsivity) or genotypes. Individuals wishing to collaborate on site can be provided with access to the colony for phenotypic or genetic assessment or for the conduct of discrete experiments. Technical support and complete anatomic and clinical pathology services are available. There is also scientific support for statistical genetic analyses.
Contact Information
Wake Forest University Primate Center
Wake Forest University School of Medicine
Medical Center Blvd.
Winston-Salem NC 27157-1040
E-mail: wfupc@wfubmc.edu
Web Site: http://www.wfubmc.edu/wfupc![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: P40 RR019963
Principal Investigator and Contact
Jay R. Kaplan, Ph.D.
336-716-1522; Fax: 336-716-1515
E-mail: jkaplan@wfubmc.edu
Additional
Contact
Matthew J. Jorgensen, Ph.D.
336-716-6935; Fax 336-716-1515
Alamogordo Primate Facility
Research Emphasis/Objectives
The Alamogordo Primate Facility (APF) houses
chimpanzees that have been used in biomedical research,
but no active, invasive research is conducted on the
site.
Services Provided
The APF provides for the long-term care and husbandry
of chimpanzees that have been used in biomedical
research. Charles River Laboratories Inc. operates the
facility under contract with the National Institutes of
Health. To be used in continuing virological research,
the animals must be transferred to active chimpanzee
research settings.
Animals
All chimpanzees at the APF have been exposed to various
microorganisms, such as hepatitis C virus and HIV. For
this reason, they may be candidates for studies related
to these diseases. The National Center for Research
Resources (NCRR) may remove infected animals from the
APF to other accredited chimpanzee facilities for
research purposes. Investigators interested in the
chimpanzees at the APF should contact Dr. Harold Watson
in NCRR's Division of Comparative Medicine to
discuss research requirements. Dr. Watson can be
reached at 301-435-0744.
Contact Information
Alamogordo Primate Facility
Holloman Air Force Base
Alamogordo, NM 88330
Contact
Harold Watson, Ph.D.
301-435-0744; Fax: 301-480-3819
E-mail: watsonh@mail.nih.gov
University of Louisiana at
Lafayette
Research Emphasis/Objectives
The center maintains and provides available research
facilities accredited by the Association for Assessment
and Accreditation of Laboratory Animal Care (AAALAC)
International; a ready source of chimpanzees of mixed
ages and sex for use in biomedical and behavioral
sciences, and also provides professional staff
necessary to support investigators with their research
needs.
Current Research
Vaccine development and testing; pharmacokinetic,
pharmacodynamic, preclinical safety, and efficacy
studies.
Services Provided
The University of Louisiana at Lafayette-New Iberia
Research Center (UL Lafayette-NIRC) is an
AAALAC-International-accredited nonhuman primate
research facility dedicated to the support of basic and
applied biomedical and behavioral research. All
proposed programs must be approved by the presenting
institution and the UL Lafayette-NIRC animal care and
use committees. State-of-the-art biomedical support
facilities are available that include access to
ultrasound, radiography with automatic processor and
computer imagery for diagnostic enhancement, and
endoscopy and laparoscopy with video monitors, camera
and color photo imagery.
Diagnostic Laboratory
A 12,000-square-foot laboratory is available for
investigators' research support requirements.
Capabilities within the laboratory include—but
are not limited to—hematology, chemistry,
microbiology, urinalysis, parasitology, and histology.
Among the investigator support procedures are Ficoll
gradient isolation of peripheral blood mononuclear
cells, platelet aggregation profiles, nonhuman primate
lymphocyte proliferation assay, and flow cytometry
(lymphocyte enumeration). Emergency generator power is
accessible in each laboratory unit and for all major
instrumentation and critical freezers.
Animals
The center cares for approximately 360 chimpanzees and
5,500 New and Old World species of nonhuman primates.
In addition to chimpanzees, the following species of
nonhuman primates are being bred at the center: Vervet
monkey ( Chlorocebus aethiops ), cynomolgus
macaque ( Macaca fascicularis ), pigtailed
macaque ( M. nemestrina ), rhesus macaque (
M. mulatta ).
Contact Information
University of Louisiana at
Lafayette
New Iberia Research Center
4401 West Admiral Doyle Drive
New Iberia, LA 70560
Web site: nirc.louisiana.edu![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: U42
RR015087
Principal Investigator and Contact
Thomas J. Rowell, D.V.M.
337-482-0225; Fax: 337-373-0057
E-mail: tjr7173@louisiana.edu
University of Texas
Research Emphasis/Objectives
Research objectives are to provide physically and
behaviorally healthy chimpanzees for critical
biomedical research and testing; to conduct relevant
research projects of benefit to chimpanzee health,
productivity, and well-being.
Current Research
Develop and improve techniques of captive management;
investigate behavioral factors influencing improvements
in the husbandry and well-being of chimpanzees; support
collaborative programs in genetic management.
Services Provided
A demographically balanced group of approximately 100
physically and behaviorally healthy chimpanzees to meet
current and future research and testing needs in the
United States. The colony is housed in eight
4,500-square-foot outdoor corrals in multiple-male
family groups. Complete facilities and services are
available for visiting scientists. Chimpanzees are
available to investigators supported by NIH grants and
contracts.
Biological Materials
Tissues and body fluids are available when coordinated
with preventive health care procedures.
Contact Information
University of Texas
M. D. Anderson Cancer Center
Department of Veterinary Sciences
650 Cool Water Drive
Bastrop, TX 78602
Web site: http://mdanderson.org![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.:
U42 RR015090
Contact
William Satterfield, D.V.M.
512-321-3991; Fax: 512-332-5208
E-mail: wsatterf@mdanderson.org
Principal Investigator
Christian R. Abee, D.V.M.
Chimpanzee Management Program
Description
The NIH Chimpanzee Management Program (ChiMP) supports long-term, cost-effective housing and maintenance at NCRR-supported facilities for chimpanzees. NCRR provides programmatic oversight of the facilities and ensures they comply with the Animal Welfare Act, and policies concerning laboratory animal care and use. READ MORE >>
Contact Information
National Center for Research Resources
National Institutes of Health
One Democracy Plaza
6701 Democracy Boulevard, MSC 4874
Bethesda, Maryland 20892-4874
Contact
William T. Watson, D.V.M., M.S.
301-435-0744; Fax: 301-480-3819
E-mail: WatsonWm@mail.nih.gov
Caribbean Primate Research Center
SPF Rhesus Monkey Program
Research Emphasis/Objectives
The objective of this program is to establish, and
maintain, a specific-pathogen-free (SPF) rhesus macaque
supply and breeding colony program at the Sabana Seca
Field Station of the Caribbean Primate Research Center
(CPRC). The CPRC program will make a significant
contribution to advancing AIDS research by providing
high-quality and healthy SPF rhesus monkeys to
NIH-sponsored research programs. The CPRC program uses
genetically characterized, MHC-typed, Indian-origin
monkeys from the CPRC's free-ranging colony on the
island of Cayo Santiago. The CPPC will donate the
founding stock for the colony from its Cayo Santiago
and Cayo Santiago-derived populations. Previous surveys
have shown that the Cayo Santiago macaques are free of
several important viruses, including retroviruses and
simian virus 40 (SV-40), and that the majority of
immature animals are negative for B-virus (Herpesvirus
simiae or Cercopithecine herpesvirus type 1. About
20-25 percent of these monkeys are also Mamu-A*01
positive. Currently, there is a shortage of SPF rhesus
monkeys for biomedical research, and the demand for
these animals is expected to increase dramatically in
the future. The establishment and maintenance of this
program at the Sabana Seca Field Station will help meet
the increased demand for both SPF (B-virus, SRV-D, SIV,
STLV-1, and SV-40-free) and Mamu-A*01 positive rhesus
monkeys. Forty-five SPF females and nine SPF males
(nine breeding groups) will be added to the colony each
year through internal recruitment from Cayo Santiago
and the Sabana Seca Field Station. MHC-typing and
selective breeding will be used to increase the
production of SPF Mamu-A*01 positive offspring. By year
five, the program will have supplied 106 offspring
including about 30 Mamu-A*01 positive animals.
Current Research
The virology laboratory conducts research on
recombinant DNA vaccines using rhesus macaques and
performs viral tests for herpes B-virus, STLV, and SIV.
The BL 2/3 Virology Laboratory has allowed CPRC to
establish the SPF program under the sponsorship of
NCRR, and one of its major objectives is to support
ongoing SPF programs. The laboratory serves as a
platform of research in vaccine development (SHIV, SIV,
dengue) and in genetics. This laboratory provides
services to the conventional and SPF CPRC colonies
(viral serology) and is collaborating with mainland
investigators (Centers for Disease Control and
Prevention) in SHIV vaccine protocols involving rhesus
macaques.
Services Provided
CPRC welcomes collaborative research with established
behavioral and biomedical investigators and encourages
the use of its animal and osteological resources for
dissertation research. Investigators are charged modest
use fees for access to the animals, computerized
database, and office space. All proposals receive
rigorous peer review and are judged on scientific
merit, feasibility, and potential overlap with ongoing
studies. Protocols using live monkeys must be approved
by the Institutional Animal Care and Use Committee
(IACUC) of the home institution, as well as the
University of Puerto Rico Medical Sciences Campus
IACUC.
Contact Information
University of Puerto Rico
Medical Sciences Campus
P.O. Box 1053
Sabana Seca, PR 00952-1053
Web site: ucm.rcm.upr.edu/cprc.html![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: U42 RR16021
Principal Investigator and Contact
Edmundo N. Kraiselburd, Ph.D.
787-764-4325; Fax: 787-764-4325
E-mail: ekraiselburd@rcm.upr.edu
Mailing Address
Unit of Comparative Medicine
Office B-315
University of Puerto Rico School of Medicine
Medical Sciences Campus
P.O. Box 365067
San Juan, PR 00936-5067
Enhancement of the CPRC SPF
Rhesus Monkey Program
Research Emphasis/Objectives
The objective of this program is to enhance the
existing specific-pathogen-free (SPF) rhesus macaque
supply and breeding colony program at the Sabana Seca
Field Station of the Caribbean Primate Research Center
(CPRC). This program uses genetically characterized,
MHC-typed, Indian-origin monkeys from established
social groups obtained from the CPRC's free-ranging
colony on the island of Cayo Santiago. The CPRC will
donate the founding stock for the colony, which
consists of 102 adult and 21 juvenile females and a
minimum of 20 sires. The establishment and maintenance
of this expanded program at the Sabana Seca Field
Station will help meet the increased demand for both
SPF (B-virus, SRV-D, SIV, and STLV-1-free) and
Mamu-A*01 positive rhesus monkeys. The founding cohort
is expected to produce a minimum of 70 infants during
the first year and an estimated total offspring of
about 400 SPF animals in five years. The CPRC's
program provides high-quality and healthy SPF rhesus
monkeys to NIH-sponsored research programs.
Current Research
The virology laboratory conducts research on
recombinant DNA vaccines using rhesus macaques and
performs viral tests for herpes B-virus, STLV, and SIV.
The BL 2/3 Virology Laboratory has allowed CPRC to
establish the specific-pathogen-free program under the
sponsorship of NCRR, and one of its major objectives is
to support ongoing SPF programs. The laboratory serves
as a platform of research in vaccine development (SHIV,
SIV, dengue) and in genetics. This laboratory provides
services to the conventional and to the SPF CPRC
colonies (viral serology) and is collaborating with
mainland investigators (Centers for Disease Control and
Prevention) in SHIV vaccine protocols involving rhesus
macaques.
Services Provided
CPRC welcomes collaborative research with established
behavioral and biomedical investigators and encourages
the use of its animal and osteological resources for
dissertation research. Investigators are charged modest
use fees for access to the animals, computerized
database, and office space. All proposals receive
rigorous peer review and are judged on scientific
merit, feasibility, and potential overlap with ongoing
studies. Protocols using live monkeys must be approved
by the Institutional Animal Care and Use Committee
(IACUC) of the home institution, as well as the
University of Puerto Rico Medical Sciences Campus
IACUC.
Contact Information
University of Puerto Rico
Medical Sciences Campus
P.O. Box 1053
Sabana Seca, PR 00952-1053
Web site: ucm.rcm.upr.edu/cprc.html![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: U24 RR18108
Principal Investigator and Contact
Edmundo N. Kraiselburd, Ph.D.
787-764-4325; Fax: 787-764-4325
E-mail: ekraiselburd@rcm.upr.edu
Mailing Address
Unit of Comparative Medicine
Office B-315
University of Puerto Rico School of Medicine
Medical Sciences Campus
P.O. Box 365067
San Juan, PR 00936-5067
Establishment of a SPF Rhesus
Macaque Colony in Texas
Research Emphasis/Objectives
This project will produce Indian-origin rhesus monkeys
( Macaca mulatta ) that are
specific-pathogen-free (SPF) for herpes B virus, SIV,
SRV, and STLV-1. The proposed colony will produce high
quality genetically characterized animals for use in
AIDS-related research by NIH grantees.
Contact Information
Southwest Foundation for Biomedical Research
Department of Comparative Medicine
P.O. Box 760549
San Antonio, TX 78245-0549
Grant No.: U24 RR18108
Principal Investigator
Larry B. Cummins, D.V.M.
210-258-9549; Fax: 210-670-3305
E-mail: bcummins@icarus.sfbr.org
Expansion of a SPF Rhesus Colony
in Louisiana
Research Emphasis/Objectives
The center's objective is development of a
specific-pathogen-free (SPF) rhesus monkey (Macaca
mulatta) breeding colony. Animals derived from the
colony are limited to use for AIDS research. Nonhuman
primates derived from the colony are seronegative for
simian immunodeficiency virus (SIV), simian T
-lymphotrophic virus (STLV-1), type D retrovirus (SRV),
and cercopithecine herpesvirus 1 (CHV1 or B-virus). The
retroviruses (SIV, STLV-1 and SRV), when present in
animals used for AIDS studies, may confound research
data. B-virus is hazardous to humans and is being
eliminated to protect personnel coming in contact with
infected animals or their tissues.
Services Provided
SPF rhesus monkeys may be requested for AIDS research
by contacting the principal investigator. The Tulane
Resource Allocation Committee has responsibility for
allocating animal resources to NIH-funded
investigators. To apply for allocation of SPF rhesus
monkeys, investigators must first complete an
application form, which is available from the principal
investigator.
Contact Information
Tulane National Primate Research Center
18703 Three Rivers Road
Covington, LA 70433
Grant No.:U24 RR18111
Principal Investigator
Rudolf P. Bohm, Jr., D.V.M.
985-671-6266; Fax: 985-871-6388
E-mail: bohm@tulane.edu
Additional Contact
James L. Blanchard, D.V.M., Ph.D.
985-871-6285
E-mail: jblanch1@tulane.edu
Production of Pedigreed SPF
Rhesus Macaques in California
Research Emphasis/Objectives
The objective of this program is to produce pedigreed
rhesus macaques of Indian origin that are free of
selected viral pathogens. These agents include:
Cercopithecine herpesvirus 1 (herpes B), simian
immunodeficiency virus (SIV), simian T-lymphotropic
virus 1, type D retrovirus, and simian foamy virus
(SFV). These animals are of known pedigrees confirmed
by microsatellite testing and are also typed for
Mamu-A*01 alleles by the UC Davis Veterinary Genetics
Laboratory. Colony status is confirmed by frequent
viral screening through the Simian Retroviral Core
Laboratory.
Current Research
Research programs are in place to use assisted
reproductive technology strategies to expand numbers of
Mamu-A*01 positive animals and other genotypes that may
be of specific research interest. The center is also
identifying additional viral pathogens to be excluded
from the specific-pathogen-free (SPF) population.
Genetic studies are under way to determine whether A*01
positive individuals are heterozygous or homozygous.
Services Provided
Animals
Scientists wishing to use pedigreed Indian origin
rhesus macaques should contact the principal
investigator. Scientists wishing to conduct research at
the California National Primate Research Center should
contact the director. Information for research access
to the primate center is available on the center's
Web site
.
Other Services
Pedigree analysis and MHC typing for rhesus macaque is
available through the UC Davis Veterinary Genetics
Laboratory.
Contact Information
California National Primate Research Center
University of California, Davis
One Shields Avenue
Davis, CA 95616-8542
Web site: www.cNPRC.ucdavis.edu![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: U42
RR016023
U24 RR018144
Principal Investigator and Contact
Nicholas Lerche, D.V.M.
530-752-6490; Fax: 530-752-2880
E-mail: nwlerche@ucdavis.edu
SPF Indian Rhesus Monkey Colony
in Louisiana
Research Emphasis/Objectives
The center's objective is development of a
specific-pathogen-free (SPF) rhesus monkey ( Macaca
mulatta ) breeding colony. Animals derived from
the colony are limited to use for AIDS research.
Nonhuman primates derived from the colony are
seronegative for simian immunodeficiency virus (SIV),
simian T-lymphotrophic virus (STLV-1), type D
retrovirus (SRV), and Cercopithecine herpesvirus 1
(CHV1 or B-virus). The retroviruses (SIV, STLV-1, and
SRV), when present in animals used for AIDS studies,
may confound research data. B-virus is hazardous to
humans and is being eliminated to protect personnel
from coming in contact with infected animals or their
tissues.
Services Provided
SPF rhesus monkeys may be requested for AIDS research
by contacting the principal investigator. The Tulane
Resource Allocation Committee has responsibility for
allocating the animals to NIH-funded investigators. To
apply for allocation of SPF rhesus monkeys must first
complete an application form, which is available
through the principal investigator.
Contact Information
Tulane National Primate Research Center
18703 Three Rivers Road
Covington, LA 70433
Grant No.: U42 RR016026
Principal Investigator
James L. Blanchard, D.V.M., Ph.D.
985-871-6285
E-mail: blanch1@tulane.edu
Additional Contact
Rudolf P. Bohm, Jr., D.V.M.
985-871-6266; Fax:985-871-6388
E-mail: bohm@tulane.edu
Specific-Pathogen-Free Rhesus
Monkeys in Oregon
Research Emphasis/Objectives
Research objectives are to: Enhance the Oregon National
Primate Research Center's specific-pathogen-free
(SPF) Indian-origin rhesus macaque breeding resource to
support AIDS research by increasing the number of
pedigreed, genetically diverse females in the breeding
colony. Manage the resource for the production of major
histocompatibility complex (MHC)-defined offspring of
known parentage for use in AIDS-related research
through the use of breeder males that are homozygous
for MHC alleles that are important for assessing
cell-mediated immune function in vaccine development.
Current Research
The center's SPF Indian-origin rhesus macaque
breeding programs have target female breeder
populations of 250 and 125, respectively. All adults
and juveniles are free of simian immunodeficiency
virus, T-lymphotrophic virus 1, type D simian
retroviruses, and Herpesvirus simiae. Frequent
microbiologic monitoring is performed to ensure SPF
status. Research objectives focus on maintaining
pedigreed, genetically diverse female breeders and
production of offspring with defined MHC class 1
haplotypes. Polymorphic microsatellite analyses are
used to verify parentage, select appropriate males, and
monitor genetic diversity in the colonies. Selective
breeding of MHC-typed animals and assisted reproductive
technology are used to enhance production of offspring
with desired MHC haplotypes. The SPF definition is
being expanded in the U24-supported colony to include
additional viral agents that are useful as models of
opportunistic infections in AIDS research or as vectors
for vaccine development such as cytomegalovirus,
rhadinovirus, spumaretrovirus, and simian virus 40.
Services Provided
Animals
SPF juvenile Indian-origin rhesus macaques, primarily
males, are available for sale to NIH grantees and other
qualifying investigators for AIDS-related research.
Blood samples and other tissues and body fluids
obtainable using routine, noninvasive clinical
procedures are available to qualifying investigators
with appropriate institutional approvals for research
animal use. Cost estimates for collection, packaging,
and shipping are available upon request. Allocation of
animals produced under this cooperative agreement will
be determined by a coordinating committee in
consultation with the NCRR program administrator to
ensure equitable distribution.
Other Services
The center's resources are available to
collaborative NIH grantees with appropriate animal care
and use approval and institutional contractual
agreements. Resources include veterinary clinical
services, biological safety level 3 laboratory and
animal containment facilities, anatomic pathology,
clinical pathology, microbiology, and flow cytometry.
Further information on the collaboration research
program is available from the associate director's
office. Contact P. Michael Conn, Ph.D., 503-690-5297,
e-mail: connm@ohsu.edu
Contact Information
Oregon National Primate Research Center
Oregon Health Sciences University, West Campus
Division of Pathobiology and Immunology
505 N.W. 185th Avenue
Beaverton, OR 97006-3499
Web site: onprc.ohsu.edu![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: U42
RR16025
U24 RR18107
Principal Investigator and Contact
Michael K. Axthelm, D.V.M.
503-690-5236; Fax: 503-690-5524
E-mail: axthelmm@ohsu.edu
Additional Contact
Gary S. Heckman, D.V.M.
503-690-5516; Fax: 503-614-3736
E-mail: heckmang@ohsu.edu
Washington M.
nemestrina SPF Breeding Colony
Research Emphasis/Objectives
Nonhuman primate species have proven to be invaluable
resources for AIDS research in several fields,
including vaccine development, therapeutic agent
discovery, and pathogenesis. Well-defined models of
AIDS currently exist in Macaca nemestrina,
utilizing a large number of primate lentiviruses and
other infectious agents. Washington NPRC plans to
expand the size of a small colony of SPF M.
nemestrina breeding animals to provide a
significant increase in the long-term availability of
appropriate nonhuman primates. In addition, the center
will expand a similar colony located in Indonesia.
Access to feral animals is not limited in this country
of origin, and the center will take advantage of this
to quickly expand the existing SPF M.
nemestrina colony to breed SPF offspring that will
be transferred to the United States.
Current Research
Create an M. nemestrina breeding colony free
of Mycobacterium tuberculosis (TB); simian
immunodeficiency virus; simian retrovirus, all
subtypes; simian T-lymphoptrophic virus, and
Cercopithecine herpesvirus 1 for application to
AIDS-related NIH research projects. Expand the M.
nemestrina breeding colony in Bogor, Indonesia, to
provide SPF juveniles negative for the same five agents
above.
Contact Information
Washington National Primate Research Center
University of Washington
Box 357330; Health Sciences Center, Room I-421
Seattle, WA 98195-7330
Web site: www.wanprc.org/wanprc![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: U24
RR018114
Principal Investigator
David M. Anderson, D.V.M.
206-616-4583; Fax: 206-616-1710
E-mail: danderson@u.washington.edu
Yerkes National Primate Research
Center SPF Breeding Colonies
Research Emphasis/Objectives
The objective of this program is to manage and breed a
colony of rhesus macaques of Indian origin that are
free of selected viral pathogens. These agents include:
Cercopithecine herpesvirus 1 (herpes B), simian
immunodeficiency virus (SIV), simian T-lymphotrophic
virus 1; and type D retrovirus. These animals are
pedigreed by microsatellite testing and are also typed
for Mamu-A*01 alleles.
Current Research
The central objective of this project is to maintain
and expand specific-pathogen-free (SPF) breeding
colonies of macaque monkeys at the Yerkes National
Primate Research Center (NPRC). As a conservative
projection, if production in the SPF colony remains
equal to or exceeds its present production of some 125
animals per year (with all females retained), the
combination of retained births from the SPF colony and
identification of virus-free infants from the non-SPF
colony will provide for growth of 150-175 animals per
year in the SPF colony. Other significant results
include beginning the genetic characterization of the
entire SPF colony for pedigree analysis in the
laboratory of Dr. Jeff Rogers at the Southwest NPRC.
Services Provided
SPF juvenile Indian-origin rhesus macaques, primarily
males, are available to NIH grantees and other
qualifying investigators for AIDS-related research.
Blood samples and other tissues and body fluids that
can be collected via noninvasive clinical procedures
are available to qualifying investigators with
appropriate institutional approvals for research animal
use. Costs to services are set by NIH policy and are
posted on the Yerkes NPRC Web site
.
Contact Information
Emory University
954 North Gatewood Road, NE
Atlanta, GA 30322
Web site: www.yerkes.emory.edu![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: U24
RR018109
Principal Investigator and Contact
Thomas P. Gordon, D.V.M.
404-727-7844; Fax: 404-727-8061
E-mail: gordon@rmy.emory.edu
Additional Contact
James Else, D.V.M.
404-727-9710; Fax: 404-727-9401
E-mail: jelse@rmy.emory.edu
Construction of a Targeted Rhesus
Macaque Microarray
Research Emphasis/Objectives
The objective is to obtain nonhuman primate sequences
for the purposes of producing NHP expression arrays,
SNP discovery and genotyping.
Current Research
Various methods were used to determine the 3' end
of all human genes. This information was then used to
select human primers that amplified the 3' end of
rhesus orthologs of human genes from rhesus macaque
genomic DNA. Sequences were deposited in GenBank's
Sequence Tagged Site database and were used by
Affymetrix to construct a whole-genome rhesus macaque
GeneChip, which became available for purchase in June
2005. The resource Web
site
includes information on the genes represented
on the GeneChip, plus links to GenBank records for
sequences of those genes. The primers developed for the
rhesus project are now being applied to two additional
projects. First, 3' UTR sequences are being
obtained for the vervet monkey, toward the goal of
developing a vervet expression array. Second, the
primers are being used in a SNP discovery project that
will aid the genotyping of rhesus macaques.
Services Provided
NHP sequences, expression arrays, SNP discovery,
genotyping.
Contact Information
Department of Genetics, Cell Biology & Anatomy
University of Nebraska Medical Center
Omaha, NE 68198-6395
Web site: rhesusgenechip.unomaha.edu![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: R24 RR017444
Principal Investigator and Contact
Robert Norgren, Ph.D.
402-559-8891; Fax: 402-559-7328
E-mail: rnorgren@unmc.edu
Additional Contact
Eliot Spindel
503-690-5512; Fax: 503-690-5384
E-mail: spindele@ohsu.edu
Creation of a Nonhuman Embryo Gene
Expression Resource
Research Emphasis/Objectives
The Primate Embryo Gene Expression Resource (PREGER)
contains a collection of nearly 200 amplified cDNA
libraries from rhesus monkey oocytes and embryos
representing a wide variety of experimental conditions.
The purpose of PREGER is to provide interested
investigators with access to molecular reagents needed
for gene expression analysis in nonhuman primate
embryos, at vastly reduced cost and labor.
Current Research
The resource is being expanded to incorporate samples
of stem cells for studies related to stem cell biology.
Determinants of oocyte quality are being sought through
a novel suppression-subtraction hybridization method
developed for application to the cDNA libraries
contained in the resource.
Services Provided
The resource can produce and distribute amplified cDNA
libraries in solution, phage libraries, dot blot
hybridization membranes for gene expression analysis,
primer sequences, and available human or rhesus monkey
cDNA probes. The resource also houses an online
searchable gene expression database, and a Web site
containing methods, contacts, bibliography, and other
tools. Registered users also receive a periodic
newsletter about relevant advances in primate
embryology. Collaborative arrangements in which gene
expression patterns of specific genes are examined, or
users contribute new experimentally manipulated samples
that can then be analyzed in conjunction with a broader
core set of samples, thereby reducing investigator
expense, are also welcomed.
Contact Information
The Fels Institute for Cancer Research and Molecular
Biology
Temple University School of Medicine
3307 North Broad Street
Philadelphia, PA 19140
Web site: www.preger.org![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: R24 RR15253
Principal Investigator and Contact
Keith Latham, Ph.D.
215-707-7577; Fax: 215-707-1454
E-mail: klatham@temple.edu
Genetic Typing Laboratory
Research Emphasis/Objectives
Objectives of the laboratory are to: Identify and
characterize previously unknown polymorphisms
(including PCR-amplified mitochondrial DNA,
Y-chromosome, and microsatellite DNA or STR loci);
study the effectiveness of alternative genetic
management strategies and the effect of demographic
factors on the population/genetic structure of captive
groups of primates; identify marker loci for genes that
influence susceptibility to retroviral, B-virus, and
other infections; and employ both ancient and
contemporary mitochondrial DNA and microsatellite DNA
loci for studies of ancestor-descendant relationships.
Services Provided
To Collaborating Scientists and Graduate Students
All principal investigators of NIH-supported
specific-pathogen-free (SPF) breeding programs or their
designees are eligible to request genetic marker
analysis on rhesus macaques ( Macaca mulatta
), crab-eating macaques ( M. fascicularis ),
pigtailed macaques ( M. nemestrina ), and
other species of Macaca and Papio in
SPF colonies; identify paternity; calculate kinship and
inbreeding coefficients; determine country of origin;
estimate parameters of genetic diversity, genetic
subdivision, and founder representation within the
colony; collaborate with principal investigators on
colony management strategies and on research involving
those data; and amplify and sequence noncoding control
region of mitochondrial DNA extracted from modern and
prehistoric (e.g., skeletal) material.
Contact Information
University of California, Davis
Department of Anthropology
209 Young Hall
Davis, CA 95616
Web site: www.anthro.ucdavis![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: R24 RR05090
Principal Investigator
David Glenn Smith, Ph.D.
530-752-6343, 8570, or 6665; Fax: 530-752-8885
Message: 530-752-0745
E-mail: dgsmith@ucdavis.edu
Additional Contacts
John W. McDonough
530-752-8570
E-mail: jwmed@ucdavis.edu
Debra George
530-752-8570
E-mail: dageorge@ucdavis.edu
Herpes B-Virus Diagnosis: National
Resource Laboratory
Research Emphasis/Objectives
To identify B-virus infections in humans and macaques
and study basic pathogenesis mechanisms of this and
other neurotropic herpesviruses; to develop control and
prevention strategies for B-virus infections in both
humans and macaques. All samples evaluated by the
resource can be used in ongoing research studies.
Current Research
Assessment of evolutionary conservation among
alpha-herpesviruses by biochemical, immunological, and
molecular biological approaches; development of
recombinant reagents; identification of effective
antiviral strategies and design of putative vaccines;
elucidation of host-virus interactions during
pathogenesis; collaborative identification/exploration
of putative alpha-herpesviruses not previously
described.
Services Provided
Diagnostic Services
This laboratory resource is designed to provide rapid
virological and serological analyses to identify
Herpesvirus simiae (B virus) infections in
humans and nonhuman primates, particularly macaques.
Virological analyses are performed by virus isolation,
polypeptide analysis, DNA restriction endonuclease
analyses, and experimental polymerase chain reaction.
Serological analyses include enzyme-linked
immunosorbent assay (ELISA), competition ELISA, and
Western blot analyses. The laboratory also provides
telephone and mail information to requestors seeking
assistance for identifying infections, and/or
CDC-derived information for handling human or macaque
cases of B-virus infection. Staff are available for
collaboration in investigating cases of B-virus
infection in humans and nonhuman primates. Resource
staff perform all diagnostic services adjacent to the
herpesvirus research laboratory of the principal
investigator. This proximity permits consultation with
and additional assistance from staff members when
required.
Other Services
Specialized biocontainment laboratory (BCL-4)
facilities, investigation of new animal models of
herpesvirus disease, antiviral testing, epidemiological
analyses of alpha-herpesvirus outbreaks, necropsy and
autopsy assistance for virological analyses of B-virus
infections, assistance in developing
specific-pathogen-free SPF primate colonies, and
isolation/characterization of nonhuman primate
alpha-herpesvirus.
Fees
Cost reimbursement for procedures performed to identify
potential B-virus infections in humans and nonhuman
primates is requested to maintain the resource.
Contact Information
Georgia State University
Viral Immunology Center
Department of Biology
50 Decatur Street
Atlanta, GA 30302-4118
Web site: www.gsu.edu/bvirus![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: P40 RR005062
Principal Investigator and Contact
Julia K. Hilliard, Ph.D.
404-651-0808; Fax: 404-651-0821
Emergency: 404-358-8168
E-mail: biojkh@panther.gsu.edu
Additional Contact
Richard Henkel, Ph.D.
404-651-0813; Fax: 404-651-0821
E-mail: biordh@panther.gsu.edu
Nete Priest
404-651-0808; Fax: 404-651-0814
E-mail:
bioyyp@panther.gsu.edu
Luminex Reagents for NHP Research
Research Emphasis/Objectives
The research objective of this resource is to facilitate and expand the use of the Luminex technology for the detection of multiple NHP cytokines in small sample volumes.
Current Research
We have tested a large number of mono- and polyclonal antibodies against human cytokines in order to improve the breadth and analytical power of our 23-plex NHP Luminex panel by increasing the number of detectable molecules in Old World monkey species. We have also cloned, sequenced and expressed IFN-a, IL-4, IL-6, IL-10, IL-18, and TNF-a from marmoset in order to generate recombinant antibodies that will be used as Luminex reagents for this NHP specie.
Services Provided
Diagnostic Services
Website with NHP crossreactivity for antibodies. Novel antibodies will be distributed to scientists who justify their need on cost-recovery bases. Detection of cytokines in body fluids and cell culture supernatant from Old World Monkeys in a fee-for-service basis.
Contact Information
Southwest National Primate Research Center
Southwest Foundation for Biomedical Research
7620 NW Loop 410
San Antonio, TX 78227
Web site: http://www.sfbr.org/pages/snprc_projects.php?p=60![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: R24 RR023345
Principal Investigator and Director
Luis D. Giavedoni, Ph.D.
210-258-9603; Fax: 210-670-3310
E-mail: Lgiavedo@sfbr.org
Additional Contact
Vida L. Hodara
210-258-9683; Fax: 210-670-3310
E-mail: vhodara@sfbr.org
NIH Nonhuman Primate Reagent Resource
Research Emphasis/Objectives
The objective of the NIH Nonhuman Primate Reagent Resource is to facilitate the use of nonhuman primate models of disease by providing reagents for targeting cell subsets or immune pathways in vivo. This is accomplished by developing new reagents specific for nonhuman primate proteins and by optimizing existing reagents for in vivo use in the nonhuman primate species.
Current Research
Current research is exploring the in vivo effectiveness of mouse/human, mouse/rhesus, fully-human and fully-rhesus recombinant monoclonal antibodies directed against cell targets. The goal is to develop reagents for administration to nonhuman primates that provide the optimal efficiency and duration of effect.
Services Provided
The resource provides antibodies for in vivo administration and for in vitro diagnostics in nonhuman primates. A database of commercial reagents that cross react with 12 different nonhuman primate species is maintained on the website. The resource also provides nonhuman primate recombinant proteins, reference reagents and cell lines.
Contact Information
Beth Israel Deaconess Medical Center
Division of Viral Pathogenesis
Center for Life Sciences 1038
3 Blackfan Circle
Boston, MA 02115
Web site: http://NHPReagents.bidmc.harvard.edu![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: R24 RR016001
Principal Investigator and Director
Keith A. Reimann, D.V.M.
617-735-4476; Fax: 617-735-4527
E-mail: kreimann@bidmc.harvard.edu
Additional Contact
Kristine Regione, Adm. Asst.
617-667-4583; Fax: 617-667-8210
E-mail: kregione@bidmc.harvard.edu
Primate Genomics
Research Emphasis/Objectives
The center's objective is to develop the resources
necessary to apply the technologies of functional
genomics to nonhuman primate research. Central to this
effort is the construction of macaque cDNA libraries,
large-scale expressed sequence tag (EST) sequencing,
and the production of macaque oligonucleotide
microarrays.
Current Research
The resources being developed are tested in the context
of integrated model systems, with particular emphasis
on SIV infection of the rhesus macaque. The goal is to
develop and make available physical and informational
genomic resources to foster hypothesis-driven research
using nonhuman primates and to increase understanding
of a primary model for AIDS research.
Services Provided
cDNA libraries or clones from a variety of macaque
tissues, macaque EST database, macaque oligonucleotide
microarray.
Contact Information
Washington National Primate Research Center
University of Washington
Box 358070
Seattle, WA 98195-8070
Web site: www.macaque.org![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: R24 RR16354
Principal Investigator
Michael G. Katze, Ph.D.
206-732-6136; Fax: 206-732-6056
E-mail: honey@u.washington.edu
Additional Contact
Shawn Iadonato, Ph.D.
206-378-0400; Fax: 206-378-0408
E-mail: siadonato@illumigen.com
Resource for Nonhuman Primate
Immune Reagents
Research Emphasis/Objectives
Research objectives include characterizing, cloning,
and quality testing nonhuman primate cytokines and
immune cell-associated molecules in vitro and in vivo.
Derivation of cytokines with extended bioavailability.
Current Research
Ongoing preparation of recombinant rhesus IL-2, IL-4,
IL-7, IL-10, IL-12, IL-15, and Ig fusion cytokines.
Custom preparation of cytokine- and cell-associated
molecule expression vectors. Testing of adjuvant effect
of defined immune enhancers in nonhuman primates.
Cloning of new cytokines, receptors, and signaling
molecules (IL-17, 21, 23, IL-7Ra, IL-15Ra, TIM3, FoxP3,
etc.).
Services Provided
Distribution of nonhuman primate cytokine/immune
molecule cDNAs for analysis and expression. Custom
preparation of cytokine- and cell-associated molecule
expression vectors. Custom preparation of recombinant
cytokines. Custom cloning of new molecules from
nonhuman primates. Expertise in cytokine analysis.
Contact Information
Department of Pathology and Laboratory Medicine
Emory University School of Medicine
1639 Pierce Drive, WMRB Room 2339
Atlanta, GA 30322
Web site: pathology.emory.edu/Villinger/index.htm![external link, opens in new window](https://webarchive.library.unt.edu/eot2008/20090115024017im_/http://www.ncrr.nih.gov/images/externallink.gif)
Grant No.: R24 RR016988
Principal Investigator
François Villinger, D.V.M., Ph.D.
404-712-2838; Fax: 404-712-1771
E-mail: fvillin@emory.edu
Additional Contact
Chadi Filfili
404-712-1767; Fax: 404-712-1771
E-mail: rnhpir@emory.edu