Transcriptional Responses to the Environment Group
2002 - present
Nechaev S, Adelman K. (2008) Promoter-proximal Pol II: when stalling speeds things up. Cell cycle (Georgetown, Tex.); 7(11):1539-1544. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18469524)
Gilchrist D.A., Nechaev S., Lee C., Gosh S.K.B, Collins J., Li L., Gilmour D.S. & Adelman K. (2008) NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly. Genes Dev.; 22(14): 1921-33. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/18628398?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum)
Nechaev S. & Adelman K. (2008) Promoter-proximal Pol II: when stalling speeds things up. Cell Cycle; 7(11): 1539-44. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/18469524?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum)
Muse G.W., Gilchrist D.A., Nechaev S., Shah R., Parker J.S., Grissom S.F., Zeitlinger J., & Adelman K. (2007) RNA polymerase is poised for activation across the genome. Nature Genetics 39(12):1507-1511. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17994021)
Zeitlinger J., Stark A., Kellis M., Hong J-W., Nechaev S., Adelman K., Levine M., & Young R.A. (2007) RNA polymerase stalling at developmental control genes in the drosophila melanogaster embryo. Nature Genetics 39(12):1512-1516. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17994019)
Adelman K.*, Wenxiang W.*, Ardehali M.B., Werner J., Zhu B., Reinberg D., & Lis J.T. (2006) The Drosophila Paf1 complex modulates chromatin structure at actively transcribed genes. (*These authors contributed equally to this work.) Mol. Cell. Biol. 26: 250-60. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16354696)
Adelman K., Marr M.T., Werner J., Saunders A., Ni Z., Andrulis E.D., & Lis J.T. (2005) Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS. Mol. Cell 17: 103-12. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15629721&query_hl=4)
Adelman K., Yuzenkova J., La Porta A., Zenkin N., Lee J., Lis J.T., Borukhov S., Wang M.D., & Severinov K. (2004) Molecular mechanism of transcription inhibition by peptide antibiotic Microcin J25. Mol. Cell 14: 753-62. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15200953&query_hl=6)
Fan X., Shi H., Adelman K., & Lis J.T. (2004) Investigating TBP interactions in transcription initiation and reinitiation with RNA aptamers that act in distinct modes. Proc. Natl. Acad. Sci. USA 101: 6934-9. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15103022&query_hl=11)
Simeonov M.F., Urbauer R.J.B., Gilmore J.M., Adelman K., Brody E.N., Niedziela-Majka A., Minakhin L., Heyduk T. & Urbauer J.L. (2003) Characterization of interactions between the bacteriophage T4 AsiA protein and RNA polymerase. Biochemistry 42 (25): 7717-26. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12820881&query_hl=12)
Minakhin L., Niedziela-Majka A., Kuznedelov K., Adelman K., Urbauer J.L., Heyduk T. & Severinov K. (2003) Interaction of T4 AsiA with its target sites in the RNA polymerase sigma70 subunit leads to distinct and opposite effects on transcription. J. Mol. Biol. 326 (3): 679-90. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12581632&query_hl=18)
Adelman K., La Porta A., Santangelo T.J., Lis J.T., Roberts J.W. & Wang M.D. (2002) Single molecule analysis of RNA polymerase elongation reveals uniform kinetic behavior. Proc Natl Acad Sci U S A 99 (21): 13538-43. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12370445&query_hl=16)
Adelman K. & Lis J.T. (2002) How does Pol II overcome the nucleosome barrier? Mol Cell; 9 (3): 451-2. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11931751&query_hl=19)
Urbauer J.L., Simeonov M.F., Urbauer R.J.B., Adelman K., Gilmore J.M., & Brody E.N. (2002) Solution structure and stability of the anti-sigma factor AsiA: implications for novel functions. Proc Natl Acad Sci U S A 99 (4): 1831-5. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11830637&query_hl=21)
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