Nuclear Protein Physiology
Anton M. Jetten, Ph.D.
Tel (919) 541-2768
Fax (919) 541-4133
P.O. Box 12233
Mail Drop D2-01
Research Triangle Park, North Carolina 27709
The Cell Biology Group studies the physiological functions of three nuclear proteins: retinoid-related orphan receptors (RORs), the Krüppel-like zinc finger proteins Glis-similar (Glis) and the receptor-associated protein 80 (RAP80). By studying their roles in several major human diseases, including asthma, chronic kidney disease, fibrosis, diabetes and cancer, the group hopes to obtain greater insights into the etiology of these diseases and to develop novel therapeutic strategies for these illnesses.
The Cell Biology Group identified several nuclear proteins, including RORγ, a member of the nuclear receptor superfamily, the Krüppel-like zinc finger proteins Glis1-3, and RAP80, a ubiquitin interacting motif containing protein. Recent studies established a role for RORγ in the regulation of lymph node development, lung inflammation, thymopoiesis, the generation of mature T cells and metabolism of xenobiotics. In addition, the group has established a role for Glis2 in the development of chronic kidney disease and fibrosis, and implicated Glis3 in the development of diabetes and polycystic kidney disease. RAP80 plays an important role in the modulation of estrogen receptor function, DNA repair, and tumorigenesis.
Major areas of research:
Anton M. Jetten, Ph.D., head of the Cell Biology Group and Deputy Chief of the Laboratory of Respiratory Biology, obtained his Ph.D. from the University of Nijmegen, The Netherlands, and completed postdoctoral studies at the Massachusetts Institute of Technology. He has published over 200 peer-reviewed journal articles and book chapters.