![](https://webarchive.library.unt.edu/eot2008/20090115010909im_/http://www.cancer.gov/images/spacer.gif) |
|
![](https://webarchive.library.unt.edu/eot2008/20090115010909im_/http://www.cancer.gov/images/spacer.gif)
rofecoxib A synthetic, nonsteroidal derivative of phenyl-furanone with antiinflammatory, antipyretic and analgesic properties and potential antineoplastic properties. Rofecoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
![](https://webarchive.library.unt.edu/eot2008/20090115010909im_/http://www.cancer.gov/images/spacer.gif)
US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090115010909im_/http://www.cancer.gov/images/spacer.gif) | Vioxx | | ![](https://webarchive.library.unt.edu/eot2008/20090115010909im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090115010909im_/http://www.cancer.gov/images/spacer.gif) | MK 966 | | ![](https://webarchive.library.unt.edu/eot2008/20090115010909im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20090115010909im_/http://www.cancer.gov/images/spacer.gif) | 4-[4'-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone | | ![](https://webarchive.library.unt.edu/eot2008/20090115010909im_/http://www.cancer.gov/images/spacer.gif) |
![](https://webarchive.library.unt.edu/eot2008/20090115010909im_/http://www.cancer.gov/images/spacer.gif)
![](https://webarchive.library.unt.edu/eot2008/20090115010909im_/http://www.cancer.gov/images/gray_spacer.gif)
![](https://webarchive.library.unt.edu/eot2008/20090115010909im_/http://www.cancer.gov/images/spacer.gif)
|
![](https://webarchive.library.unt.edu/eot2008/20090115010909im_/http://www.cancer.gov/images/spacer.gif) |