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indibulin A synthetic small molecule with antimitotic and potential antineoplastic activities. Indibulin binds to a site on tubulin that is different from taxane- or Vinca alkaloid-binding sites, destabilizing tubulin polymerization and inducing tumor cell cycle arrest and apoptosis. This agent has been shown to be active against multidrug-resistant (MDR) and taxane- resistant tumor cell lines. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Code names: | ![](https://webarchive.library.unt.edu/eot2008/20090115071917im_/http://www.cancer.gov/images/spacer.gif) | D-24851 ZIO-301 | | ![](https://webarchive.library.unt.edu/eot2008/20090115071917im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20090115071917im_/http://www.cancer.gov/images/spacer.gif) | (N-(pyridin-4-yl)-[1-(4-chlorbenzyl)-indol-3-yl]-glyoxyl-amid) | | ![](https://webarchive.library.unt.edu/eot2008/20090115071917im_/http://www.cancer.gov/images/spacer.gif) |
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