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porfiromycin An N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20090115000203im_/http://www.cancer.gov/images/spacer.gif) | methyl mitomycin methyl mitomycin C Methylmitomycin porfiromycine porphyromycin | | ![](https://webarchive.library.unt.edu/eot2008/20090115000203im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090115000203im_/http://www.cancer.gov/images/spacer.gif) | Promycin | | ![](https://webarchive.library.unt.edu/eot2008/20090115000203im_/http://www.cancer.gov/images/spacer.gif) | Code names: | ![](https://webarchive.library.unt.edu/eot2008/20090115000203im_/http://www.cancer.gov/images/spacer.gif) | ENT-50825 U-14743 | | ![](https://webarchive.library.unt.edu/eot2008/20090115000203im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure names: | ![](https://webarchive.library.unt.edu/eot2008/20090115000203im_/http://www.cancer.gov/images/spacer.gif) | - [1aS-(1a alpha,8beta,8a alpha,8b alpha)]-6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
- N-methylmitomycin C
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