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darbepoetin alfa
A recombinant analog of the endogenous cytokine erythropoietin, an erythropoiesis-stimulating protein. Due to the addition of two carbohydrate chains, darbepoetin alfa exhibits a three-fold greater half-life than does erythropoietin. Similar to erythropoietin, darbopoietin alfa binds to and activates epoetin receptors, thereby inducing the differentiation and maturation of erythrocyte progenitors, stimulating endothelial cell proliferation, and stimulating B-cell proliferation and immunoglobulin production. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | Novel Erythropoiesis Stimulating Protein | | | | US brand name: | | Aranesp | | | | Foreign brand name: | | Nespo | | | | Abbreviation: | | NESP | | | | Code name: | | KRN321 | | |
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