Zeldin, D.C., Kobayashi, J., Falck, J.R., Winder, B.S., Hammock, B.D., Snapper, J.R., and J.H. Capdevila. Regio- and Enantiofacial Selectivity of Epoxyeicosatrienoic Acid Hydration by Cytosolic Epoxide Hydrolase. J. Biol. Chem. 268: 6402-6407, 1993. [Abstract] (http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8454612&dopt=Abstract)[PDF] (http://www.jbc.org/cgi/reprint/268/9/6402.pdf)
Zeldin, D.C., Wei, S., Falck, J.R., Hammock, B.D., Snapper, J.R., and Capdevila, J.H. Metabolism of Epoxyeicosatrienoic Acids by Cytosolic Epoxide Hydrolase: Substrate Structural Determinants of Asymmetric Catalysis. Arch. Biochem. Biophys. 316: 443-451, 1995. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7840649&dopt=Abstract)[PDF] (http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WB5-45NJ01G-PY-1&_cdi=6701&_orig=search&_coverDate=01%2F31%2F1995&_sk=996839998&wchp=dGLbVzb-lSztW&_acct=C000000150&_version=1&_userid=10843&md5=5ee8e25da8e7d43e5e671825112c174b&ie=f.pdf)
Zeldin, D.C., Plitman, J.D., Kobayashi, J., Miller, R., Philpot, R., Snapper, J.R., and Capdevila, J.H. The Rabbit Pulmonary Cytochrome P-450 Arachidonic Acid Metabolic Pathway: Characterization and Significance. J. Clin Invest. 95: 2150-2160, 1995. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7738183&dopt=Abstract)
Zeldin, D.C., Dubois, R.N., Falck, J.R., and Capdevila, J.H.. Molecular Cloning, Expression, and Characterization of a Human Cytochrome P450 Isoform that Epoxidizes Endogenous Arachidonic Acid Pools. Arch. Biochem. Biophys. 322: 76-86, 1995. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7574697&dopt=Abstract)[PDF] (http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WB5-45NHYVG-HS-1&_cdi=6701&_orig=search&_coverDate=09%2F10%2F1995&_sk=996779998&wchp=dGLbVzb-lSztW&_acct=C000000150&_version=1&_userid=10843&md5=c8f4e401b96b3246683565d0891dab08&ie=f.pdf)
Wu, S., Moomaw, C., Tomer, K.B., Falck, J.R., and Zeldin, D.C. Molecular Cloning and Expression of CYP2J2, a Human Cytochrome P450 Arachidonic Acid Epoxygenase Highly Expressed in Heart. J. Biol. Chem. 271: 3460-3468, 1996. [Abstract] (http://www.jbc.org/cgi/content/abstract/271/7/3460)[Full Text] (http://www.jbc.org/cgi/content/full/271/7/3460)
Zeldin, D.C., Moomaw, C., Jesse, N., Tomer, K., Beetham, J., Hammock, B.D., and Wu, S. Biochemical Characterization of the Human Liver Cytochrome P450 Arachidonic Acid Metabolic Pathway. Arch. Biochem. Biophys. 330: 87-96, 1996. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8651708&dopt=Abstract)[PDF] (http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WB5-45N4NC2-B9-1&_cdi=6701&_orig=search&_coverDate=06%2F01%2F1996&_sk=996699998&wchp=dGLbVzb-lSztW&_acct=C000000150&_version=1&_userid=10843&md5=9d3966814c73eec397a8b167dbe15b2d&ie=f.pdf)
Zeldin, D.C., Foley, J., Ma, J., Boyle, J.E., Pascual, J.M.S., Moomaw, C.R., Tomer, K.B., Steenbergen, C., and Wu, S. CYP2J Subfamily P450s in the Lung: Expression, Localization, and Potential Functional Significance. Mol. Pharmacol. 50: 1111-1117, 1996. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8913342&dopt=Abstract)
Zeldin, D.C., Foley, J., Boyle, J.E., Moomaw, C.R., Tomer, K.B., Parker, C., Steenbergen, C., and Wu, S. Predominant Expression of an Arachidonate Epoxygenase to Islets of Langerhans Cells in Human and Rat Pancreas: Evidence for a Role of Epoxyeicosatrienoic Acids in Insulin, Glucagon, and Somatostatin Secretion. Endocrinology 138: 1338-1346, 1997. [Abstract] (http://endo.endojournals.org/cgi/content/abstract/138/3/1338)[Full Text] (http://endo.endojournals.org/cgi/content/full/138/3/1338)
Wu, S., Chen, W., Murphy, E., Gabel, S., Tomer, K.B., Foley, J., Steenbergen, C., Falck, J.R. Moomaw, C. and Zeldin, D.C. Molecular Cloning, Expression, and Functional Significance of a Cytochrome P450 Highly Expressed in Rat Heart Myocytes. J. Biol. Chem. 272: 12551-12559, 1997. [Abstract] (http://www.jbc.org/cgi/content/abstract/272/19/12551)[Full Text] (http://www.jbc.org/cgi/content/full/272/19/12551)
Zeldin, D.C., Foley, J., Goldsworthy, S.M., Cook, M.E., Boyle, J.E., Ma, J., Moomaw, C.R., Tomer, K.B., Steenbergen, C., and Wu, S. CYP2J Subfamily P450s in the Gastrointestinal Tract: Expression, Localization, and Potential Functional Significance. Mol. Pharmacol. 51: 931-943, 1997. [Abstract] (http://molpharm.aspetjournals.org/cgi/content/abstract/51/6/931)[Full Text] (http://molpharm.aspetjournals.org/cgi/content/full/51/6/931)
Pascual, J., McKenzie, A., Yankaskas, J., Falck, J.R., and Zeldin, D.C. Epoxygenase Metabolites of Arachidonic Acid Affect Electrophysiologic Properties of Rat Tracheal Epithelial Cells. J. Pharmacol. Exp. Ther. 286: 772-779, 1998. [Abstract] (http://jpet.aspetjournals.org/cgi/content/abstract/286/2/772)[Full Text] (http://jpet.aspetjournals.org/cgi/content/full/286/2/772)
Ma, J., Ramachandran, S., Fiedorek, F.T., and Zeldin, D.C. Mapping of the CYP2J Genes to Human Chromosome 1 and Mouse Chromosome 4. Genomics 49: 152-155, 1998. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9570962&dopt=Abstract)[PDF] (http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WG1-45JB8NV-BY-1&_cdi=6809&_orig=search&_coverDate=04%2F01%2F1998&_sk=999509998&wchp=dGLbVlb-lSztz&_acct=C000000150&_version=1&_userid=10843&md5=c3640720d0de5b73df7b2cfe07a665f4&ie=f.pdf)
Qu, W., Rippe, R.A.,Ma, J., Scarborough, P.E., Biagini, C.P., Fiedorek, F.T., Travlos, G.,Parker, C., and Zeldin, D.C. Nutritional Status Modulates Rat Liver P450 Arachidonic Acid Metabolism. Mol. Pharmacol. 54: 504-513, 1998. [Abstract] (http://molpharm.aspetjournals.org/cgi/content/abstract/54/3/504)[Full Text] (http://molpharm.aspetjournals.org/cgi/content/full/54/3/504)
Luo, G., Zeldin, D.C., Blaisdell, J.A., Hodgson, E., and Goldstein, J.A. Cloning and Expression of Murine CYP2Cs and their Ability to Metabolize Arachidonic Acid. Arch. Biochem. Biophys. 357: 45-57, 1998. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9721182&dopt=Abstract)[PDF] (http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WB5-45KKRK8-4N-1&_cdi=6701&_orig=search&_coverDate=09%2F01%2F1998&_sk=996429998&wchp=dGLbVzb-lSztW&_acct=C000000150&_version=1&_userid=10843&md5=33b0bafcd5b40a79a3953668270adeae&ie=f.pdf)
Scarborough, P.E., Ma, J., Qu, W. and Zeldin, D.C. CYP2J Subfamily P450 and Their Role in the Bioactivation of Arachidonic Acid in Extrahepatic Tissues. Drug Met. Rev. 31: 205-234, 1999. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10065373&dopt=Abstract)
Chen, J., Capdevila, J.H., Zeldin, D.C., and Rosenberg, R.L. Inhibition of Cardiac L-type Calcium Channels by Epoxyeicosatrienoic Acids. Mol. Pharmacol. 55: 288-295, 1999. [Abstract] (http://molpharm.aspetjournals.org/cgi/content/abstract/55/2/288)[Full Text] (http://molpharm.aspetjournals.org/cgi/content/full/55/2/288)
Ma, J., Qu, W., Scarborough, P.E., Tomer, K.B., Moomaw, C.R., Maronpot, R., Davis, L.S., Breyer, M.D., and Zeldin, D.C. Molecular Cloning, Enzymatic Characterization, Developmental Expression, and Cellular Localization of a Mouse Cytochrome P450 Highly Expressed in Kidney. J. Biol. Chem. 274: 17777-17788, 1999. [Abstract] (http://www.jbc.org/cgi/content/abstract/274/25/17777)[Full Text] (http://www.jbc.org/cgi/content/full/274/25/17777)
Node, K., Huo, Y., Ruan, L.-L., Yang, B., Splecker, M., Ley, K., Zeldin, D.C. and Liao, J.K. Anti-inflammatory Actions of Epoxygenase-Derived Eicosanoids. Science 285: 1276-1279, 1999. [Abstract] (http://www.sciencemag.org/cgi/content/abstract/285/5431/1276)[Full Text] (http://www.sciencemag.org/cgi/content/full/285/5431/1276)
Oleksiak, M.F., Wu, S., Parker, C., Karchner, S.I., Stegeman J.J., and Zeldin, D.C. Identification, Functional Characterization and Regulation of a New Cytochrome P450 Subfamily, the CYP2Ns. J. Biol.Chem. 275: 2312-2321, 2000. [Abstract] (http://www.jbc.org/cgi/content/abstract/275/4/2312)[Full Text] (http://www.jbc.org/cgi/content/full/275/4/2312)
Yu, Z., Huse, L.M., Ma, J., Adler, P., Graham, L., Ma, J., Zeldin, D.C., and Kroetz, D.L. Increased CYP2J Expression and Epoxyeicosatrienoic Acid Formation in the Spontaneously Hypertensive Rat Kidney. Mol. Pharmacol. 57: 1011-1020, 2000. [Abstract] (http://molpharm.aspetjournals.org/cgi/content/abstract/57/5/1011)[Full Text] (http://molpharm.aspetjournals.org/cgi/content/full/57/5/1011)
Zeldin, D.C. and Liao, J.K. Reply: Cytochrome P450-derived Eicosanoids and the Vascular Wall. Trends in Pharmacological Sciences 21: 127-128, 2000. [Full Text] (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1K-40199B0-4&_coverDate=04%2F01%2F2000&_alid=70960382&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=4893&_sort=d&_acct=C000000150&_version=1&_urlVersion=0&_userid=10843&md5=5e29a87c176aa63c522c9aeaa60fc2db)
Tsao, C.-C., Foley, J., Coulter, S.J., R. Maronpot, Zeldin, D.C., and Goldstein, J.A. CYP2C40, a Unique Arachidonic Acid 16-Hydroxylase, is the Major CYP2C Isoform in the Murine Intestinal Tract. Mol. Pharmacol. 58: 279-287, 2000. [Abstract] (http://molpharm.aspetjournals.org/cgi/content/abstract/58/2/279)[Full Text] (http://molpharm.aspetjournals.org/cgi/content/full/58/2/279)
Jacobs, E.R. and Zeldin, D.C. The Lung HETEs (and EETs) Up. Am. J. Physiol., 280: H1-H10, 2001. [Abstract] (http://ajpheart.physiology.org/cgi/content/abstract/280/1/H1)[Full Text] (http://ajpheart.physiology.org/cgi/content/full/280/1/H1)
Dai, D., Zeldin, D.C., Blaisdell, J.A., Chanas, B., Coulter, S.J., Ghanayem, B.I. and Goldstein, J.A. Polymorphisms in Human CYP2C8 Decrease Metabolism of the Anticancer Drug Paclitaxel and Arachidonic Acid. Pharmacogenetics. 11: 597-607, 2001.
Node, K., Ruan, X.-L., Dai, J., Yang, S.-X., Graham, L., Zeldin, D.C. and Liao, J.K. Activation of Gas Mediates Induction of Tissue-type Plasminogen Activator Gene Transcription by Epoxyeicosatrienoic Acids. J. Biol. Chem. 276: 15983-15989, 2001. [Abstract] (http://www.jbc.org/cgi/content/abstract/276/19/15983)[Full Text] (http://www.jbc.org/cgi/content/full/276/19/15983)
Qu, W., Bradbury, A., Tsao, C.-C., Maronpot, R., Harry, G.J., Davis, L., Breyer, M.D., Waalkes, M., Parker, C., Falck, J.R., Chen, J., Rosenberg, R. and Zeldin, D.C. Cytochrome P450 CYP2J9, a New Mouse Arachidonic Acid ω-1 Hydroxylase Predominately Expressed in Brain. J. Biol. Chem. 276: 25467-25479, 2001. [Abstract] (http://www.jbc.org/cgi/content/abstract/276/27/25467)[Full Text] (http://www.jbc.org/cgi/content/full/276/27/25467)
Zeldin, D.C. Epoxygenase Pathways of Arachidonic Acid Metabolism. J. Biol. Chem. 276: 36059-36062, 2001. [Abstract] (http://www.jbc.org/cgi/content/abstract/276/39/36059)[Full Text] (http://www.jbc.org/cgi/content/full/276/39/36059)
Yang, B., Graham, L. Falck, J.R., Liao, J.K. and Zeldin, D.C. Overexpression of Cytochrome P450 CYP2J2 Protects Against Hypoxia-Reoxygenation Injury in Cultured Bovine Aortic Endothelial Cells. Mol. Pharm. 60: 310-320, 2001. [Abstract] (http://molpharm.aspetjournals.org/cgi/content/abstract/60/2/310)[Full Text] (http://molpharm.aspetjournals.org/cgi/content/full/60/2/310)
Tsao, C.-C., Coulter, S.J., Chien, A, Maronpot, R., Goldstein, J.A. and Zeldin, D.C. Identification and Distribution of Five Murine CYP2Cs in Extrahepatic Tissues and their Stereoselectivity for Arachidonic Acid Metabolism. J. Pharmacol. Exp. Ther. 299: 39-47, 2001. [Abstract] (http://jpet.aspetjournals.org/cgi/content/abstract/299/1/39)[Full Text] (http://jpet.aspetjournals.org/cgi/content/full/299/1/39)
Kroetz, D.L and Zeldin, D.C. Cytochrome P450 Pathways of Arachidonic Acid Metabolism. Current Opinion in Lipidology. 13: 273-283, 2002.
King, L.M., Ma, J., Srettabunjong, S., Li, L., Graves, J., Spiecker, M., Liao, J.K., Mohrenweiser, H. and Zeldin, D.C. Cloning of the CYP2J2 Gene and Identification of Functional Polymorphisms. Mol. Pharmacol. 61: 840-852, 2002. [Abstract] (http://molpharm.aspetjournals.org/cgi/content/abstract/61/4/840)[Full Text] (http://molpharm.aspetjournals.org/cgi/content/full/61/4/840)
Ma, J., Bradbury, J.A., King,L., Maronpot, R., Davis, L., Breyer, M., and Zeldin, D.C. Molecular cloning and characterization of mouse CYP2J6, an unstable cytochrome P450 isoform. Biochem. Pharmacol. 64: 1447-1460, 2002. [Abstract] (http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12417258&dopt=Abstract)[Full Text] (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T4P-46X97SP-9&_coverDate=11%2F15%2F2002&_alid=70956808&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=4980&_sort=d&_acct=C000000150&_version=1&_urlVersion=0&_userid=10843&md5=013d5b77b5dae8bb98bd274a657170c0)
Zhao, X., Pollock, D.M., Inscho, E.W., Zeldin, D.C., and Imig, J.D. Decreased Renal Cytochrome P450 2C Enzymes and Impaired Vasodilation Are Associated With Angiotensin Salt-Sensitive Hypertension. Hypertension 41: 709 - 714, 2003. [Abstract] (http://hyper.ahajournals.org/cgi/content/abstract/41/3/709)[Full Text] (http://hyper.ahajournals.org/cgi/content/full/41/3/709)
Oleksiak, M.F., Wu, S., Parker, C., Qu, W., Cox, R., Zeldin, D.C., and Stegeman, J.J. Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase. Arch. Biochem. Biophys. 411: 223-234, 2003. [Abstract] (http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12623071&dopt=Abstract)[Full Text] (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WB5-481MHG2-1&_coverDate=03%2F15%2F2003&_alid=78907555&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=6701&_sort=d&view=c&_acct=C000000150&_version=1&_urlVersion=0&_userid=10843&md5=2dacba0ee761756686af15f8750f15f5)
Yaghi, A., Bradbury, J.A., Zeldin, D.C., Mehta, S., Bend, J.R., and McCormack, D.G. Pulmonary Cytochrome P450 2J4 (CYP2J4) is Reduced in a Rat Model of Acute Pseudomonas Pneumonia. Am. J. Physiol. 285: L1099-L1105, 2003. [Abstract] (http://ajplung.physiology.org/cgi/content/abstract/285/5/L1099)[Full Text] (http://ajplung.physiology.org/cgi/content/full/285/5/L1099)
Zhao, X., Pollock, D.M., Zeldin, D.C., and Imig, J.D. Decreased renal cytochrome P450 2C enzymes and impaired vasodilation are associated with angiotensin salt-sensitive hypertension. Hypertension. 41:709-714, 2003. [Abstract] (http://hyper.ahajournals.org/cgi/content/abstract/41/3/709)[Full Text] (http://ajplung.physiology.org/cgi/content/abstract/285/5/L1099)
Blackshear, P.J., Graves, J., Stumpo, D.J., Cobos, I., Rubenstein, J.L., and Zeldin, D.C. Graded Phenotypic Response to Partial and Complete Deficiency of a Brain-Specific Variant of the Winged Helix Transcription Factor RFX4. Development 130:4539-4552, 2003. [Abstract] (http://dev.biologists.org/cgi/content/abstract/130/19/4539)[Full Text] (http://dev.biologists.org/cgi/content/full/130/19/4539)
Wang, H., Lin, L., Jiang, J., Wang, Y., Lu, Z.Y., Bradbury, J.A., Lih, F.B., Wang, D.W, and Zeldin, D.C.. Up-regulation of Endothelial Nitric Oxide Synthase by Endothelium-Derived Hyperpolarizing Factor Involves Mitogen-activated Protein Kinase and Protein Kinase C Signaling Pathways. J. Pharmacol. Exp. Ther. 307: 753-764, 2003. [Abstract] (http://jpet.aspetjournals.org/cgi/content/abstract/307/2/753)[Full Text] (http://jpet.aspetjournals.org/cgi/content/full/307/2/753)
Oleksiak, M.F., Wu, S., Parker, C., Qu, W., Cox, R., Zeldin D.C., and Stegeman, J.J. Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase. Arch. Biochem. Biophys. 411: 223-234, 2003. [Abstract] (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WB5-481MHG2-1&_user=10843&_coverDate=03%2F15%2F2003&_alid=146731346&_rdoc=1&_fmt=summary&_orig=search&_qd=1&_cdi=6701&_sort=d&_docanchor=&view=c&_acct=C000000150&_version=1&_urlVersion=0&_userid=10843&md5=4b8b93643988faf6c04792999f25ed8c)[Full Text] (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WB5-481MHG2-1&_coverDate=03%2F15%2F2003&_alid=146731346&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=6701&_sort=d&view=c&_acct=C000000150&_version=1&_urlVersion=0&_userid=10843&md5=20156f2e39dcb02264672d7143efe148)
Zhao, X., Pollock, D.M., Zeldin, D.C., and Imig, J.D. Salt-sensitive hypertension after exposure to angiotensin is associated with inability to upregulate renal epoxygenases. Hypertension 42: 775-780, 2003. [Abstract] (http://hyper.ahajournals.org/cgi/content/abstract/42/4/775)[Full Text] (http://hyper.ahajournals.org/cgi/content/full/42/4/775)
Zhao, C., Wang, P., Xiao, X., Chao, L., Wang, D.W., and Zeldin, D.C. Gene Therapy with Human Tissue Kallikrein Reduces Hypertension and Hyperinsulinemia in Fructose-Induced Hypertensive Rats. Hypertension 42: 1026-1033, 2003. [Abstract] (http://hyper.ahajournals.org/cgi/content/abstract/42/5/1026)[Full Text] (http://hyper.ahajournals.org/cgi/content/full/42/5/1026)
Pfister, S.L., Spitzbarth, N., Zeldin, D.C., Lafite, P., Mansuy, D. and Campbell, W.B. Rabbit Aorta Converts 15-HPETE to Trihydroxyeicosatrienoic Acids: Potential Role of Cytochrome P450. Arch. Biochem. Biophys. 420: 142-152, 2003. [Abstract] (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WB5-49S7X2J-5&_user=10843&_coverDate=12%2F01%2F2003&_alid=146727916&_rdoc=1&_fmt=summary&_orig=search&_qd=1&_cdi=6701&_sort=d&_docanchor=&view=c&_acct=C000000150&_version=1&_urlVersion=0&_userid=10843&md5=71afd864974f2ec0f987635654f0d7a9)[Full Text] (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WB5-49S7X2J-5&_coverDate=12%2F01%2F2003&_alid=146727916&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=6701&_sort=d&view=c&_acct=C000000150&_version=1&_urlVersion=0&_userid=10843&md5=7c61d0bf353ac0aac09c2a52f21429d7)
Lee, C.R. and Zeldin, D.C. The Reality of Pharmacogenomics: Optimizing Therapeutic Decision Making. Environ. Health Perspect. 111: A566-A567, 2003. [Abstract] (http://ehp.niehs.nih.gov/txg/docs/2003/111-11/editorial/edit.html)[PDF] (http://ehp.niehs.nih.gov/txg/docs/2003/111-11/editorial/editorL.pdf)
Nelson, D.R., Zeldin, D.C., Hoffman, S., Maltais, L., Wain, H., and Nebert, D.W. Comparison of Cytochrome P450 (CYP) Genes from the Mouse and Human Genomes: Nomenclature Recommendations for Genes, Pseudogenes, and Alternative-Splice Variants. Pharmacogenetics 14: 1-18, 2004. [Abstract] (http://www.jpharmacogenetics.com/pt/re/pharmgen/abstract.00008571-200401000-00001.htm;jsessionid=BGj3y3qEojaV2KCys04B5PKzCoqg722g59s3XKPkJNpCQGbXAVpQ!-1272544809!-949856031!9001!-1)
Yaghi, A., Bend. J.R., Webb, C.D., Zeldin, D.C., Weicker, S., Mehta, S., and McCormack, D.G. Excess Nitric Oxide Decreases Cytochrome P450 2J4 Content and P450-Dependent Arachidonic Acid Metabolism in Lung of Rats with Acute Pneumonia. Am. J. Physiol.286:L1260-L1267, 2004. [Abstract] (http://ajplung.physiology.org/cgi/content/abstract/286/6/L1260)[Full text] (http://ajplung.physiology.org/cgi/content/full/286/6/L1260)
Ma, J., Graves, J., Bradbury, J.A., Swope, D., King, L., Qu, W., Clark, J., Myers, P., Walker, V., Lindzey, J., Korach, K., and Zeldin, D.C. Regulation of Mouse Renal CYP2J5 Expression by Sex Hormones. Mol. Pharmacol. 65: 730-743, 2004. [Abstract] (http://molpharm.aspetjournals.org/cgi/content/abstract/65/3/730)[Full Text] (http://molpharm.aspetjournals.org/cgi/content/full/65/3/730)
Wang, H., Zhao, Y., Bradbury, J.A., Graves, J.P., Foley, J., Blaisdell, J.A., Goldstein, J.A. and Zeldin, D.C. Cloning, Expression and Characterization of Three New Mouse Cytochrome P450 Enzymes and Partial Characterization of Their Fatty Acid Oxidation Activities. Mol. Pharmacol. 65: 1148-1158, 2004. [Abstract] (http://molpharm.aspetjournals.org/cgi/content/abstract/65/5/1148)[Full Text] (http://molpharm.aspetjournals.org/cgi/content/full/65/5/1148)
DeLozier, T.C., Tsao, C.-C., Coulter, S.J., Foley, J., Bradbury, J.A., Zeldin, D.C. and Goldstein, J.A. CYP2C44, a New Murine CYP2C that Metabolizes Arachidonic Acid to Unique Stereospecific Products. J. Pharmacol. Exp. Ther. 310:845-854, 2004. [Abstract] (http://jpet.aspetjournals.org/cgi/content/abstract/310/3/845)[Full Text] (http://jpet.aspetjournals.org/cgi/content/full/310/3/845)
Speicker, M., Darius, H., Hankeln, T., Soufi, M., Sattler, A., Schaefer, J.R., Node, K., Borgel, J., Mugge, A., Lindpainter, K., Huesing, A., Maisch, B., Zeldin, D.C., and Liao, J.K. Risk of Coronary Artery Disease Associated with Polymorphism of a Cytochrome P450 Epoxygenase, CYP2J2. Circulation 110: 2131-2136, 2004. [Abstract] (http://circ.ahajournals.org/cgi/content/abstractll/110/15/2132)[Full Text] (http://circ.ahajournals.org/cgi/content/full/110/15/2132)
Seubert, J., Yang, B., Bradbury, J.A., Graves, J., Miller, L., Gabel, S., Gooch, R., Foley, J., Newman, J.W., Mao, L., Rockman, H.A., Hammock, B.D., Murphy, E., and Zeldin, D.C. Enhanced Postischemic Functional Recovery in CYP2J2 Transgenic Hearts Involves Mitochondrial ATP-Sensitive K+ Channels and p42/44 MAPK pathway. Circulation Research 95: 506-514, 2004. [Abstract] (http://circres.ahajournals.org/cgi/content/abstract/95/5/506)[Full Text] (http://circres.ahajournals.org/cgi/content/full/95/5/506)
Xiao, Y.F., Ke, Q., Seubert, J.M., Bradbury, J.A., Graves, J., Miller, L., Falck, J.R., Krausz, K., Gelboin, H.V., Morgan, J.P. and Zeldin, D.C. Enhancement of Cardiac L-type Calcium Currents in Transgenic Mice with Cardiac-Specific Overexpression of CYP2J2. Mol. Pharmacol. 66:1607-16, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15361551&query_hl=1)[Full Text] (http://molpharm.aspetjournals.org/cgi/content/full/66/6/1607)[PDF] (http://molpharm.aspetjournals.org/cgi/reprint/66/6/1607)
Nelson, D.R., Zeldin, D.C., Hoffman, S., Maltais, L., Wain, H., and Nebert, D.W. Comparison of Cytochrome P450 (CYP) Genes from the Mouse and Human Genomes: Nomenclature Recommendations for Genes, Pseudogenes, and Alternative-Splice Variants.Pharmacogenetics 14:1-18, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15128046&query_hl=5&itool=pubmed_docsum)
King, L.M., Gainer, J.V., David, G.L., Dai, D., Goldstein, J.A., Brown, N.J. and Zeldin, D.C. Single Nucleotide Polymorphisms in the CYP2J2 and CYP2C8 Genes and the Risk of Hypertension. Pharmacogenetics and Genomics 15: 7-13, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15864120&query_hl=7&itool=pubmed_docsum)
Seubert, J.M., Graves, J.P., Collins, J.B., Sieber, S.O., Paules, R.S. , Kroetz, D.L. and Zeldin, D.C. Differential Renal Gene Expression in Pre-hypertensive and Hypertensive Spontaneously Hypertensive Rats. American Journal of Physiology 289: F552-F561, 2005. [Abstract] (http://ajprenal.physiology.org/cgi/content/abstract/289/3/F552)[Full Text] (http://ajprenal.physiology.org/cgi/content/full/289/3/F552)
Jiang, J.G., Chen, C.L., Card, J.W., Yang, S., Chen, J.X., Fu, X.N., Ning, Y.G., Xiao, X., Zeldin, D.C. and Wang, D.W. Cytochrome P450 2J2 Promotes the Neoplastic Phenotype of Carcinoma Cells and is Upregulated in Human Tumors. Cancer Research 65: 4707-4715, 2005. [Abstract] (http://cancerres.aacrjournals.org/cgi/content/abstract/65/11/4707)[Full Text] (http://cancerres.aacrjournals.org/cgi/content/full/65/11/4707)
Wang, Y., Wei, X., Xiao, X., Hui, R., Card, J.W., Carey, M.A., Wang, D.W. and Zeldin, D.C. Arachidonic Acid Epoxygenase Metabolites Stimulate Endothelial Cell Growth and Angiogenesis Involved in MAP Kinase and PI3 Kinase/Akt Signaling Pathways. Journal of Pharmacology and Experimental Therapeutics 314: 522-532, 2005. [Abstract] (http://jpet.aspetjournals.org/cgi/content/abstract/314/2/522)[Full Text] (http://jpet.aspetjournals.org/cgi/content/full/314/2/522)
Fornage, M., Lee, C.R., Dorris, P.A., Bray, M.S., Heiss, G., Zeldin, D.C. and Boerwinkle, E. The Soluble Epoxide Hydrolase Gene Harbors Sequence Variation Associatred with Susceptibility to and Protection from Incident Ischemic Stroke. Human Molecular Genetics 14: 2829-2837, 2005. [Abstract] (http://hmg.oxfordjournals.org/cgi/content/full/14/19/2829)[Full Text] (http://hmg.oxfordjournals.org/cgi/content/full/14/19/2829)
Lee CR, North KE, Bray MS, Fornage M, Seubert JM, Newman JW, Hammock BD, Couper DJ, Heiss G, Zeldin DC. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) Study. Human molecular genetics 2006 15(10):1640-1649. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16595607)
Cotton RB, Hazinski TA, Morrow JD, Roberts LJ, Zeldin DC, Lindstrom DP, Lappalainen U, Law AB, Steele S. Cimetidine does not prevent lung injury in newborn premature infants. Pediatric research 2006 59(6):795-800. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&b=pubmed&dopt=Abstract&list_uids=16641218)
Larsen, B.T., Miura, H., Hatoum, O.A., Campbell, W.B., Hammock, B.D., Zeldin, D.C., Falck, J.R., Gutterman, D.D. Epoxyeicosatrienoic and Dihydroxyeicosatrienoic Acids Dilate Human Coronary Arterioles via BKCa Channels: Implications for Soluble Epoxide Hydrolase Inhibition. American Journal of Physiology 290: H491-H499, 2006. [Abstract] (http://ajpheart.physiology.org/cgi/content/abstract/290/2/H491)[Full Text] (http://ajpheart.physiology.org/cgi/content/full/290/2/H491)
Cotton, R.B., Sundell, H., Zeldin, D.C., Morrow, J.D., Roberts, L.J., Hazinski, T.A., Law, A.B. and Steele, S. Inhaled Nitric Oxide Attenuates Hyperoxic Lung Injury in Lambs. Pediatric Research 59: 142-146, 2006. [Abstract] (http://www.pedresearch.org/cgi/content/abstract/59/1/142)[Full Text] (http://www.pedresearch.org/cgi/content/full/59/1/142)
Larsen, B.T., Miura, H., Hatoum, O.A., Campbell, W.B., Hammock, B.D., Zeldin, D.C., Falck, J.R., Gutterman, D.D. Epoxyeicosatrienoic and Dihydroxyeicosatrienoic Acids Dilate Human Coronary Arterioles via BKCa Channels: Implications for Soluble Epoxide Hydrolase Inhibition. American Journal of Physiology 290: H491-H499, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16258029&query_hl=9&itool=pubmed_docsum)
Cotton, R.B., Sundell, H., Zeldin, D.C., Morrow, J.D., Roberts, L.J., Hazinski, T.A., Law, A.B. and Steele, S. Inhaled Nitric Oxide Attenuates Hyperoxic Lung Injury in Lambs. Pediatric Research 59: 142-146, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16327001&query_hl=12&itool=pubmed_docsum)
Paine, M.F., Hart, H.L., Lundington, S.S., Haining, R.L., Rettie, A.E. and Zeldin, D.C. The Human Intestinal Cytochrome P450 Pie. Drug Metabolism and Disposition 34:880-6, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16467132&query_hl=8&itool=pubmed_docsum)
Cotton, R.B., Hazinski, T.A., Morrow, J.D., Roberts, L. J., Zeldin, D.C., Lindstrom, D.P., Lappalainen, U., Law, A.B. and Steele, S. Cimetidine Does Not Prevent Lung Injury in Newborn Premature Infants. Pediatric Research 59: 795-800, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16641218&query_hl=12&itool=pubmed_docsum)
Lafite, P., Dijols, S., Buison, D., Macherey, A.C., Zeldin, D.C., Dansette, P.M. and Mansuy, D. Design and Synthesis of Selective, High-Affinity Inhibitors of Human P450 2J2. Bioorganic and Medicinal Chemistry Letters 16: 2777-2780, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16495056&query_hl=27&itool=pubmed_docsum)
Lee, C.R., North, K.E., Bray, M.S., Fornage, M., Seubert, J.M., Newman, J.W., Hammock, B.D., Couper, D.J., Heiss, G., and Zeldin, D.C. Genetic Variation in Soluble Epoxide Hydrolase (EPHX2) and Risk of Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study. Human Molecular Genetics 15: 1640-1649, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16595607&query_hl=41&itool=pubmed_docsum)
Zhang, D., Stumpo, D.J., Graves, J.P., DeGraff, L.M., Grissom, S.F., Collins, J.B., Li, L., Zeldin, D.C. and Blackshear, P.J. Identification of Potential Target Genes for RFX4_v3, a Transcription Factor Critical for Brain Development. Journal of Neurochemistry 98: 860-875, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16893423&query_hl=48&itool=pubmed_docsum)
Seubert, J.M., Zeldin, D.C., Nithipathikom, K., and Gross, G.J. Role of Epoxyeicosatrienoic Acids in Protecting the Myocardium Following Isthemia/Reperfusion Injury. Prostaglandins and Other Lipid Mediators 82: 50-59, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Search&db=pubmed&term=epoxyeicosatrienoic+acids+in+protecting+the+myocardium+following+ischemia%2Freperfusion+injury&tool=fuzzy&ot=Epoxyeicosatrienoic+Acids+in+Protecting+the+Myocardium+Following+Isthemia%2FReperfusion+Injury)
Lee, C.R., North, K.E., Bray, M.S., Avery, C.L., Mosher, M.J., Couper, D.J., Coresh, J., Folsom, A.R., Boerwinkle, E., Heiss, G. and Zeldin, D.C. NOS3 Polymorphisms, Cigarette Smoking, and Cardiovascular Disease Risk: The Atherosclerosis Risk in Communities (ARIC) Study. Pharmacogenetics and Genomics 16: 891-899, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17108813&query_hl=59&itool=pubmed_docsum)
Lu, T., Ye, D., Wang, X., Seubert, J.M., Graves, J., Bradbury, J.A., Zeldin, D.C. and Lee, H.C. Cardiac and Vascular KATP Channels in Rats Are Activated by Endogenous Epoxyeicosatrienoic Acids Through Different Mechanisms. Journal of Physiology (London) 575.2: 627-644, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16793897&query_hl=65&itool=pubmed_docsum)
Seubert, J.M., Sinal, C.J., Graves, J.P., DeGraff, L.M., Bradbury, J.S., Lee, C.R., Goralski, K.B., Carey, M.A., Lauria, A., Newman, J.W., Hammock, B.D., Falck, J.R., Roberts, H., Rockman, H.A., Murphy, E., and Zeldin, D.C. Role of Soluble Epoxide Hydrolase in Postischemic Recovery of Heart Contractile Function. Circulation Research 99: 442-450, 2006. ()[Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16857962&query_hl=65&itool=pubmed_docsum)
Gaedigk, A., Baker, D., Totah, R., Gaedigk, R., Pearce, R.E., Vyhlidal, C., Zeldin, D.C. and Leeder, J.S. Variability of CYP2J2 Expression in Human Fetal Tissues. Journal of Pharmacology and Experimental Therapeutics 319: 523-532, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16868033&query_hl=71&itool=pubmed_docsum)
Wang, M.S., Saulter, J.Y., Usuki, E., Cheung, Y.L., Hall, M., Bridges, A.S., Loewen, G., Parkinson, O.T., Stephens, C.E., Allen, J.L., Zeldin, D.C., Boykin, D.W., Tidwell, R.R., Parkinson, A., Paine, M.F., Hall, J.E. CYP4F Enzymes are the Major Enzymes in Human Liver Microsomes that Catalyze the O-Demethylation of the Antiparasitic Prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime]. Drug Metabolism and Disposition 34: 1985-1994, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16997912&query_hl=19&itool=pubmed_docsum)
Lee, C.R., North, K.E., Bray, M.S., Couper, D.J., Heiss, G. and Zeldin, D.C. CYP2J2 and CYP2C8 Polymorphisms and Coronary Heart Disease Risk: the Atherosclerosis Risk in Communities (ARIC) Study. Pharmacogenetics and Genomics 2006. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17429317)
Yang S, Lin L, Chen J-X, Lee CR, Seubert JM, Wang Y, Wang H, Chao Z-R, Tao D-D, Gong J-P, Lu Z-Y, Wang DW, Zeldin DC, . Cytochrome P450 epoxygenases protect endothelial cells from apoptosis induced by tumor necrosis factor-α via MAPK and PI3K/Akt signaling pathways. American journal of physiology. Heart and circulatory physiology 2007 1 (H142-H151). Abstract(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17322420)
Lafite P, Dijols S, Zeldin DC , Dansette PM, Mansuy D, . Selective, competitive, and mechanism-based inhibitors of human cytochrome P450 2J2. Archives of biochemistry and biophysics 2007 464(2):155-168. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17470359)
Ke Q, Xiao Y-F, Bradvury JA, Graves JP, DeGraff LM, Seubert JM, Zeldin DC. Electrophysiological properties of cardiomyocytes isolated from CYP2J2 transgenic mice. Molecular Pharmacology 4: 1-11, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17652182)
Nusing RM, Schweer H, Fleming I, Zeldin DC, Wegmann M. Expoxyeicosatrienoic acids affect electrolyte transport in renal tubular epithelial cells: Dependence on cyclooxygenase and cell polarity. American journal of Physiology. Renal Physiology 1: F288-F298, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17494091)
Lafite P, André F, Zeldin DC, Dansette PM, Mansuy D. Unusual regioselectivity and active site topology of human cytochrome P450 2J2. Biochemistry 36: 10237-10247, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17705402)
Lee, C.R., Bottone, F.G., Krahn, J., Li, L., Mohrenweiser, H., Cook, M.E., Petrovich, R.M., Bell, D.A., Eling, T.E., and Zeldin, D.C. Identification and Functional Characterization of Polymorphisms in Human Cyclooxygenase-1 (PTGS1). Pharmacogenetics and Genomics 17: 145-160, 2007. [Abstract]
Yuan, G., Deng, J., Wang, T., Zhao, C., Xu, X., Wang, P., Voltz, J.W., Edin, M.L., Xiao, X., Chao, L., Chao, J., Zhang, X.A., Zeldin, D.C., and Wang, D.W. Tissue Kallikrein Reverses Insulin Resistance and Attenuates Nephropathy in Diabetic Rats by Activation of Phosphatidylinositol 3-Kinase/Protein Kinase B and Adenosine 5’-Monophosphate-Activated Protein Kinase Signaling Pathways. Endocrinology 148: 2016-2026, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17272402)
DeLozier, T., Kissling, G.E., Coulter, S.J., Dai, D., Foley, J., Bradbury, J.A., Murphy, E., Steenbergen, C., Zeldin, D.C., and Goldstein, J.A. Detection of Human CYP2C8, CYP2C9 and CYP2J2 Cardiovascular Tissues. Drug Metabolism and Disposition 35: 682-688, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17220242)
Zhang, D., Zeldin, D.C., and Blackshear, P.J. Regulatory Factor X4 Variant 3: A Transcription Factor Involved in Brain Development and Disease. Journal of Neuroscience Research 85: 3515-3522, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17510980)
Nüsing, R.M. Schweer, H., Fleming, I., Zeldin, D.C., and Wegmann, M. Epoxyeicosatrienoic Acids Affect Electrolyte Transport in Renal Tubular Epithelial Cells: Dependence on Cyclooxygenase and Cell Polarity. American Journal of Physiology – Renal Physiology, 293: F288-298, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17494091)
Lafite, P., Dijols, S., Zeldin, D.C., Dansette, P.M., and Mansuy, D. Selective Competitive and Mechanism-Based Inhibitors of Human Cytochrome P450 2J2. Archives of Biochemistry and Biophysics 464: 155-168, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17470359)
Jiang, J.G., Ning, Y.G., Chen, C., Ma, D., Liu, Z.J., Yang, S., Zhou, J., Xiao, X., Zhang, X.A., Edin, M.L, Card, J.W., Wang, J., Zeldin, D.C., and Wang, D.W. Cytochrome P450 Epoxygenase Promotes Human Cancer Metastasis. Cancer Research 67: 6665-6674, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17638876)
Wang, M.Z., Wu, J.Q., Bridges, A.S., Zeldin, D.C., Kornbluth, S., Tidwell, R.R., Hall, J.E., and Paine, M.F. Human Enteric Microsomal CYP4F Enzymes O-Demethylate the Antiparasitic Prodrug Pafuramidine. Drug Metabolism and Disposition 35: 2067-2075, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17709372)
Zhang, L., Ding, H., Yan, J., Hui, R., Wang, W., Kissling, G.E., Zeldin, D.C., and Wang, D.W. Genetic Variation in Cytochrome P450 2J2 and Soluble Epoxide Hydrolase and the Risk of Ischemic Stroke in a Chinese Population. Pharmacogenetics and Genomics In Press, 2007.
Lee, C.R., North, K.E., Bray, M.S., Couper, D.J., Heiss, G., and Zeldin, D.C. Cyclooxygenase Polymorphisms and Risk of Cardiovascular Events: The Atherosclerosis Risk in Communities (ARIC) Study. Clinical Pharmacology and Therapeutics 83: 52-60, 2008. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17495879)
Larsen, B.T., Gutterman, D.D., Sato, A., Toyama, K., Campbell, W.B., Zeldin, D.C., Falck, J.R., and Miura, H. Hydrogen peroxide inhibits cytochrome P450 epoxygenases: Interaction between two endothelium-derived hyperpolarizing factors. Circulation Research 102: 59-67, 2008. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17975109)
Moshal, K.S., Zeldin, D.C., Sen, U., Sithu, S.D., Tyagi, N., Ayotunde, A., and Tyagi, S.C. Cytochrome P450 (CYP) 2J2 Gene Transfection Attenuates MMP-9 via Inhibition of NF‑kB in Hyperhomocysteinemia. Journal of Cellular Physiology In Press, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18181170)
van Waterschoot, R.A.B., van Herwaarden, A.E., Lagas, J.S., Sparidans, R.W., Wagenaar, E., van der Kruijssen, C.M.M., Goldstein, J.A., Zeldin, D.C., Beijnen, J.H., and Schinkel, A.H. Midazolam Metabolism in Cytochrome P450 3A Knockout Mice Can Be Attributed to Upregulated CYP2C Enzymes. Molecular Pharmacology In Press, 2008 [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18156313)
Zhang L, Ding H, Yan J, Hui R, Wang W, Kissling G.E., Zeldin D.C., Wang D.W. Genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in a Chinese population. Pharmacogenetics and Genomics 18(1): 45-51, 2008. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18216721)
van Waterschoot RAB , van Herwaarden AE, Lagas JS, Sparidans RW, Wagenaar E, van der Kruijssen CMM, Goldstein JA, Zeldin DC, Beijnen JH, Schinkel AH. Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to upregulated CYP2C enzymes. Molecular pharmacology 73(3):1029-1036, 2008. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18156313)
Zhang D, Harry JG, Blackshear PJ, Zedlin DC. G-Protein Pathway Suppressor 2 (GPS2)interacts with the Regulatory Factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator. The Journal of biological chemistry 283(13):8580-8590, 2008. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18218630)
Moshal KS, Zeldin DC, Sithu SD, Sen U, Tyagi N, Kumar M, Hughes WM, Metreveli N, Rosenberger DSE, Singh M, Vacek TP, Rodriguez WE, Ayotunde A, Tyagi SC. Cytochrome P450 (CYP) 2J2 gene transfection attenuates MMP-9 via inhibition of NF-k(beta) in hyperhomocysteinemia. Journal of cellular physiology 215(3):771-781, 2008. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18181170)
Tu L, Xu X, Wan H, Zhou C, Deng J, Xu G, Xiao W, Xiao X, Chen Y, Edin ML, Voltz JW, Zeldin DC, Wang DW. Delivery of recombinant adeno-associated virus-mediated human tissue kallikrein for therapy of chronic renal failure in rats. Human gene therapy 19(4):318-330, 2008.
[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18402547)
Boyle, J.E., Lindroos, P.M., Rice, A.B., Zhang, L., Zeldin, D.C., and Bonner, J.C.. Prostaglandin-E2 Counteracts Interleukin-1 Stimulated Up-regulation of Platelet-Derived Growth Factor -Receptor on Rat Pulmonary Myofibroblasts. Am. J. Resp. Cell Mol. Biol. 20: 433-440, 1999. [Abstract] (http://ajrcmb.atsjournals.org/cgi/content/abstract/20/3/433)[Full Text] (http://ajrcmb.atsjournals.org/cgi/content/full/20/3/433)
Gavett, S.H., Madison, S.L., Chulada, P., Scarborough, P.E., Qu, W., Boyle, J.E., Tiano, H., Lee, C.A., Langenbach, R., Roggli, V. and Zeldin, D.C. Allergic Lung Responses are Increased in PGH Synthase Deficient Mice. J. Clin. Invest. 104: 721-732, 1999. [Abstract] (http://www.jci.org/cgi/content/abstract/104/6/721)[Full Text] (http://www.jci.org/cgi/content/full/104/6/721)
Zeldin, D.C., Wohlford-Lenane, C., Chulada, P., Bradbury, J.A., Scarborough, P.E., Roggli, V., Langenbach, R. and Schwartz, D.A. Airway Inflammation and Responsiveness in Prostaglandin H Synthase-Deficient Mice Exposed to Bacterial Lipopolysaccharide. Am. J. Resp. Cell Mol. Biol. 25: 457-465, 2001. [Abstract] (http://ajrcmb.atsjournals.org/cgi/content/abstract/25/4/457)[Full Text] (http://ajrcmb.atsjournals.org/cgi/content/full/25/4/457)
Fritsche, E., Baek, S.J., King, L.M., Zeldin, D.C., Eling, T.E. and Bell, D.A. Functional Characterization of COX-2 Polymorphisms. J. Pharmacol. Exp. Therap. 299: 468-476, 2001. [Abstract] (http://jpet.aspetjournals.org/cgi/content/abstract/299/2/468)[Full Text] (http://jpet.aspetjournals.org/cgi/content/full/299/2/468)
Camitta, M.G.W., Gabel, S.A., Chulada, P.C., Bradbury, A.J., Langenbach, R., Zeldin, D.C., and Murphy, E. Cyclooxygenase-1 and -2 Knockout Mice Demonstrate Increased Cardiac Ischemia/Reperfusion Injury, but are Protected by Acute Preconditioning. Circulation. 104: 2453-2458, 2001. [Abstract] (http://circ.ahajournals.org/cgi/content/abstract/104/20/2453)[Full Text] (http://circ.ahajournals.org/cgi/content/full/104/20/2453)
Zeldin, D.C. The 5-Lipoxygenase Pathway: A New Therapeutic Target for the Treatment of Pulmonary Fibrosis. Am. Rev. Resp. Crit. Care Med. 165: 146-147, 2002. [Abstract] (http://ajrccm.atsjournals.org/cgi/content/abstract/165/2/229)[Full Text] (http://ajrccm.atsjournals.org/cgi/content/full/165/2/229)
Bonner, J.C., Rice, A., Bradbury, J.A., Chulada, P.C., Moomaw, C., Morgan, D., Nyska, A., Tiano, H.F., Zeldin, D.C. and Langenbach, R. Cyclooxygenase (COX)-2 Null Mice, but not COX-1 Null Mice, are Susceptible to Vanadium-Induced Pulmonary Fibrosis. Am. J. Pathology 161: 459-470, 2002. [Abstract] (http://ajp.amjpathol.org/cgi/content/abstract/161/2/459)[Full Text] (http://ajp.amjpathol.org/cgi/content/full/161/2/459)
Carey, M.A., Germolec, D.R., Bradbury, J.A., Gooch, R.A., Moorman, M.P., Flake, G.P., Langenbach, R., and Zeldin, D.C. Accentuated Th2 Airway Response After Allergen Challenge in COX-1-/- But Not COX-2-/- Mice. Am. J. Respir. Crit. Care Med. 167: 1509-1515, 2003. [Abstract] (http://ajrccm.atsjournals.org/cgi/content/abstract/167/11/1509)[Full Text] (http://ajrccm.atsjournals.org/cgi/content/full/167/11/1509)
Carey, M., Germolec, D., Langenbach, R. and Zeldin, D.C. Cyclooxygenase Enzymes in Allergic Inflammation and Asthma. Prost. Leuk. Essen. Fatty Acids. 69: 157-162, 2003. [Abstract] (http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12895598&dopt=Abstract)[Full Text] (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WPH-495740P-B&_coverDate=09%2F30%2F2003&_alid=108517196&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=6991&_sort=d&view=c&_acct=C000000150&_version=1&_urlVersion=0&_userid=10843&md5=fe55cb997f00d4cb17549a0589170eb3)
Carey, M., Germolec, D., Langenbach, R., and Zeldin, D.C. Cyclooxygenase Enzymes in Allergic Inflammation and Asthma. Prostaglandins Leukot. Essent. Fatty Acids 69: 157-162, 2003. [Abstract] (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WPH-495740P-B&_user=10843&_coverDate=09%2F30%2F2003&_alid=146730379&_rdoc=1&_fmt=summary&_orig=search&_qd=1&_cdi=6991&_sort=d&_docanchor=&view=c&_acct=C000000150&_version=1&_urlVersion=0&_userid=10843&md5=cd044aa74b8b0cb11554b761d16a2cce)[Full Text] (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WPH-495740P-B&_coverDate=09%2F30%2F2003&_alid=146730379&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=6991&_sort=d&view=c&_acct=C000000150&_version=1&_urlVersion=0&_userid=10843&md5=adadac147a7c398816f9888b66e327dee)
Carey, M.A., Germolec, D.R., Bradbury, J.A., Gooch, R.A., Moorman, M.P., Flake, G.P., Langenbach, R., and Zeldin, D.C. Accentuated T Helper Type 2 Airway Response After Allergen Challenge in cyclooxygenase-1-/- but not Cyclooxygenase-2 -/- Mice. Am. J. Respir. Crit. Care Med. 167: 1509-1515, 2003. [Abstract] (http://ajrccm.atsjournals.org/cgi/content/abstract/167/11/1509)[Full Text] (http://ajrccm.atsjournals.org/cgi/content/full/167/11/1509)
Carey, M.A., Bradbury, J.A., Langenbach, R., Zeldin, D.C. and Germolec, D.R. Contrasting Effects of Cyclooxygenase-1 (COX-1) and COX-2 Deficiency on the Host Response to Influenza A Viral Infection. Journal of Immunology 175: 6878-6884, 2005. [Abstract] (http://www.jimmunol.org/cgi/content/abstract/175/10/6878)[Full Text] (http://www.jimmunol.org/cgi/content/full/175/10/6878)
Lee, C.R., Bottone, F.G., Krahn, J., Li, L., Cook, M.E., Petrovich, R.M., Mohrenweiser, H., Eling, T.E. and Zeldin, D.C. Identification and Functional Characterization of Polymorphisms in COX-1. Pharmacogenetics and Genomics In Press, 2006.
Card JW, Carey MA, Bradbury JA, Graves JP, Lih FB, Moorman MP, Morgan DL, DeGraff LM, Zhao Y, Foley JF, Zeldin DC. Cyclooxygenase-1 overexpression decreases basal airway responsiveness but not allergic inflammation. Journal of immunology (Baltimore, Md. : 1950) 2006 7 (4785-4793). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16982919)
Card JW, Voltz JW, Carey MA, Bradbury JA, DeGraff LM, Lih FB, Bonner JC, Morgan DL, Flake GP, Zeldin DC. Cyclooxygenase-2 deficiency exacerbates bleomycin-induced lung dysfunction but not fibrosis. American journal of respiratory cell and molecular biology 2007 3 (300-308). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17496151)
Lee CR , North KE, Bray MS , Couper DJ, Heiss G, Zeldin DC. Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) Study. Clinical pharmacology and therapeutics 2008 83(1):52-60. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17495879)
Card, J.W., Carey, M.A., Bradbury, J.A., DeGraff, L.M., Morgan, D.L., Moorman, M.P., Flake, G.P., and Zeldin, D.C. Gender Differences in Murine Airway Responsiveness and Lipopolysaccharide-Induced Inflammation. J. Immunol. 177 : 621-630, 2006.
Carey, M.A., Card, J.W., Bradbury, J.A., Moorman, M.P., Haykal-Coates, N., Gavett, S.H., Graves, J.P., Walker, V.R., Flake, G.P., Voltz, J.W., Zhu, D., Jacobs, E.R., Dakhama, A., Larsen, G.L., Loader, J.E., Gelfand, E.W. Germolec, D.R, Korach, K.S. and Zeldin, D.C. Spontaneous Airway Hyperresponsiveness in Estrogen Receptor-α Deficient mice. American Journal of Respiratory and Critical Care Medicine In Press, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17095746&query_hl=51&itool=pubmed_docsum)
Card, J.W., Voltz, J.W., Ferguson, C.D., Carey, M.A., DeGraff, L.M., Peddada, S.D., Morgan, D.L. and Zeldin, D.C. Male Sex Hormones Promote Vagally-Mediated Reflex Airway Responsiveness to Cholinergic Stimulation. American Journal of Physiology – Lung Physiology In Press, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17158599&query_hl=51&itool=pubmed_docsum)
Carey MA, Card JW, Voltz JW, Arbes SJ Jr, Germolec DR, Korach KS, Zeldin DC. It's all about sex: male-female differences in lung development and disease. Trends in endocrinology and metabolism: TEM 2007 8 (308-313). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17764971)
Elliot, L., Arbes, S.J., Harvey, E.S., Lee, R.C., Salo, P.M., Cohn, R.D., London, S.J., and Zeldin, D.C. Dust Weight and Asthma Prevalence in the National Survey of Lead and Allergens in Housing (NSLAH). Environmental Health Perspectives 115: 215-220, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17384767)
Carey, M.A., Card, J.W., Voltz, J.W., Jacobs, E.R., Dakhama, A., Larsen, G., Gelfand, E.W., and Zeldin, D.C. Airways Responsiveness Should be a Measurement of the Responsiveness of Airways – Reply. American Journal of Respiratory and Critical Care Medicine 176: 215-216, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17384767)
Carey, M.A., Card, J.W., Voltz, J.W., Jacobs, E.R., Dakhama, A., Larsen, G., Gelfand, E.W., and Zeldin, D.C. Airways Responsiveness Should be a Measurement of the Responsiveness of Airways – Reply. American Journal of Respiratory and Critical Care Medicine 176: 215-216, 2007.
Carey, M.A., Card, J.W., Voltz, J.W., Germolec, D.R., Korach, K.S., and Zeldin, D.C. The Impact of Sex and Sex Hormones on Lung Physiology and Disease: Lessons from Animal Studies. American Journal of Physiology – Lung Physiology 293: L272-278, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17575008)
Sever, M., Arbes, S.J., Gore, J.C., Santangelo, R.G., Vaughn, B., Mitchell, H., Schal, C., and Zeldin, D.C. Cockroach Allergen Reduction by Cockroach Control Alone in Low-Income, Urban Homes – A Randomized Control Trial. Journal of Allergy and Clinical Immunology 120: 848-855, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17825893)
Carey, M.A., Card, J.W., Voltz, J.W., Arbes, S.J., Germolec, D.R., Korach, K.S., and Zeldin, D.C. It’s All About Sex: Gender, Lung Development and Lung Disease. Trends in Endocrinology and Metabolism 18: 308-313, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17764971)
Arbes, S.J., Gergen, P.J., Vaughn, B., and Zeldin, D.C. Asthma Cases Attributable to Atopy: Results from the Third National Health and Nutrition Examination Survey. Journal of Allergy and Clinical Immunology 120: 1139-1145, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17889931)
Zeldin, D.C., Card., J.W., Carey, M.A., and Voltz, J.A. Lung Impedance Measurements Are/Are Not More Useful than Simpler Measurements of Lung Function in Animal Models of Pulmonary Disease. Journal of Applied Physiology 103: 1909-1910, 2007. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18098389)
Salo, P.M., Arbes, S.J., Crockett, P.W., Thorne, P.S., Cohn, R.D., and Zeldin, D.C. Exposure to Multiple Indoor Allergens in U.S. Homes and Relationship to Asthma. Journal of Allergy and Clinical Immunology In Press, 2008.
Resnick, D.B. and Zeldin, D.C. Environmental Health Research on Hazards in the Home and the Duty to Warn. Bioethics In Press, 2008.
Voltz JW, Card JW, Carey MA, DeGraff LM, Ferguson CD, Flake GP, Bonner
JC, Korach KS, Zeldin DC. Male sex hormones exacerbate lung function
impairment after bleomycin-induced pulmonary fibrosis. American journal
of respiratory cell and molecular biology 39(1):45-52, 2008.
[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18276795)
Card JW, Zeldin DC, Bonner JC, Nestmann ER. Pulmonary applications and toxicity of engineered nanoparticles. American journal of physiology. Lung cellular and molecular physiology 295(3):L400-L411, 2008. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18641236)
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