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pegylated granulocyte colony stimulating factor MAXY-G34 A long-acting, pegylated recombinant variant of human granulocyte colony-stimulating factor (G-CSF) with immunomodulating activity. Pegylated granulocyte colony stimulating factor MAXY-G34 contains multiple non-naturally occurring lysines that have been introduced into
alpha helixes of wild type human G-CSF as pegylation sites; other naturally occurring lysine residues have been removed to prevent pegylation and the variant G-CSF is pegylated with methoxypolyethylene glycol succinimidyl propionate (mPEG SPA) at three amino acid residues. Similar to endogenous G-CSF, this agent binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. A difference in the degree of pegylation may account for the extended half-life of this agent compared to pegfilgrastim which is pegylated at only one amino acid residue. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090114234911im_/http://www.cancer.gov/images/spacer.gif) | PEG-CSF MAXY-G34 | | ![](https://webarchive.library.unt.edu/eot2008/20090114234911im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090114234911im_/http://www.cancer.gov/images/spacer.gif) | MAXY-G34 | | ![](https://webarchive.library.unt.edu/eot2008/20090114234911im_/http://www.cancer.gov/images/spacer.gif) |
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