Nominations to the Testing Program
Nominations in Review 2003
Substances Recommended for Study:
- Acrylamide and Glycidamide
- Antimony trisulfide
- Cadmium telluride
- Cedarwood oil, Virginia
- Chondroitin sulfate
- Dimethylethanolamine
- Drugs positive for QT Interval Prolongation/Induction of Torsade Proarrhythmia
- Glucosamine
- Nanoscale materials
- trans-Resveratrol
- Tetrabromobisphenol A
- Tetrabromobisphenol A bis(2,3-dibromopropyl ether)
- Tungsten
Substances for Which No Study is Recommended at this Time:
Chemicals studied by the NTP are selected mainly on the basis of human exposure, production levels, chemical structure, and available toxicological data. Selection of an agent for a study does not imply that the agent is hazardous or a potential carcinogen in laboratory animals; likewise, an agent not selected for toxicologic study by the Program should not be taken to mean that the agent is not potentially hazardous or potentially carcinogenic in laboratory rodents. Substances are identified by a common or generic name and CAS Registry No. where appropriate.
111 T.W. Alexander Drive
Research Triangle Park, NC
(919) 541-5710 (voice)
(919) 541-3647 (fax)
[ Send Email ]
For information, questions or comments, contact:
Dr. Scott A. Masten
Office of Chemical Nomination and Selection
Environmental Toxicology Program
National Institute of Environmental Health Sciences
111 T.W. Alexander Drive
Research Triangle Park, NC
(919) 541-5710 (voice)
(919) 541-3647 (fax)
[ Send Email ]
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Acrylamide and Glycidamide (additional information) [79-06-1],[5694-00-8] |
U.S Food and Drug Administration | Toxicological characterization including toxicokinetic, mechanistic, and carcinogenicity studies | Inadequate information available to accurately assess human health risks from exposure to acrylamide in foodstuffs; a properly designed well-conducted, GLP-compliant bioassay with appropriate ancillary studies is needed to provide dose response information and account for the food matrix through which humans are exposed |
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Antimony trisulfide [1345-04-6] |
National Cancer Institute | Chronic toxicity/ carcinogenicity | Significant human exposure in occupational settings and suspicion of carcinogenicity |
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Cadmium telluride (additional information) [1306-25-8] |
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Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Cedarwood oil, Virginia [8000-27-9] |
National Cancer Institute | Subchronic toxicity |
|
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Chondroitin sulfate [9007-28-7] [9082-07-9] (sodium salt) |
National Cancer Institute | Chronic toxicity/ carcinogenicity alone and in combination with glucosamine | Widespread long-term use as a dietary supplement and inadequate data to assess safety |
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Dimethylethanolamine [108-01-0] |
National Institute of Environmental Health Sciences | Toxicological characterization including toxicokinetic, reproductive and developmental toxicity, mechanistic, and carcinogenicity studies |
|
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Drugs positive for QT Interval Prolongation/Induction of Torsade Proarrhythmia [No CAS No.] |
U.S Food and Drug Administration | Non-clinical safety pharmacology studies of both problematic and non-problematic drugs in the conscious canine telemetry model to better establish the sensitivity and specificity of this in vivo model system for evaluating the property of a test agent to prolong QT interval at relevant exposures in humans | QT interval prolongation and torsade de pointes is a high priority cause for concern in drug development and regulatory safety evaluation; a clear definition of the strengths, limitations, and future performance characteristics of the canine telemetry model for pre-clinical safety assessment is needed | Initiate a study program to develop in vitro and in vivo test systems for assessing QT interval prolongation |
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Glucosamine [3416-24-8] |
National Cancer Institute | Chronic toxicity/ carcinogenicity alone and in combination with chondroitin sulfate | Widespread long-term use as a dietary supplement and inadequate data to assess safety |
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Nanoscale materials [No CAS No.] |
Rice University Center for Biological and Environmental Nanotechnology | Toxicological characterization of several representative classes of nanomaterials | Intense current and anticipated future research and development focus; further studies and development of appropriate toxicological methods are needed to adequately assess health effects |
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
trans-Resveratrol [501-36-0] |
National Institute of Environmental Health Sciences | Toxicological characterization |
|
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Tetrabromobisphenol A [79-94-7] |
National Institute of Environmental Health Sciences | Toxicological characterization including neurodevelopmental toxicity and carcinogencity studies | High production volume, widespread human exposure and suspicion of thyroid toxicity/tumorigenicity |
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Tetrabromobisphenol A bis(2,3-dibromopropyl ether) [21850-44-2] |
National Institute of Environmental Health Sciences |
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|
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
Tungsten [7440-33-7] |
National Center for Environmental Health | Toxicological characterization including carcinogenicity | Important industrial materials; insufficient data to assess human health implications of elevated urinary tungsten levels |
Toxicological studies:
|
Substance [CAS No.] |
Nominated by | Nominated for | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|---|
4-Phenylcyclohexene [4994-16-5] |
Private Individuals | Toxicological characterization including genotoxicity and neurotoxicity | Present in indoor environments primarily from carpet emissions; concern that it has not been adequately tested for potential health effects | No toxicological studies at this time due to low suspicion of hazard based on available human exposure and toxicity information |
Web page last updated on September 12, 2008