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fluconazole
A synthetic triazole with antifungal activity. Fluconazole preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols, the loss of normal fungal sterols, and fungistatic activity. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| US brand name: | | Diflucan | | | | Abbreviation: | | FCZ | | | | Chemical structure name: | | alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol | | |
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