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procarbazine hydrochloride The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20081005085642im_/http://www.nci.nih.gov/images/spacer.gif) | Ibenzmethyzin Ibenzmethyzin Hydrochloride Ibenzmethyzine Hydrochloride MIH MIH hydrochloride PCB Hydrochloride PCZ Procarbazin | | ![](https://webarchive.library.unt.edu/eot2008/20081005085642im_/http://www.nci.nih.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20081005085642im_/http://www.nci.nih.gov/images/spacer.gif) | Matulane | | ![](https://webarchive.library.unt.edu/eot2008/20081005085642im_/http://www.nci.nih.gov/images/spacer.gif) | Foreign brand names: | ![](https://webarchive.library.unt.edu/eot2008/20081005085642im_/http://www.nci.nih.gov/images/spacer.gif) | Natulan Natulanar Natunalar | | ![](https://webarchive.library.unt.edu/eot2008/20081005085642im_/http://www.nci.nih.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20081005085642im_/http://www.nci.nih.gov/images/spacer.gif) | PCB | | ![](https://webarchive.library.unt.edu/eot2008/20081005085642im_/http://www.nci.nih.gov/images/spacer.gif) | Code names: | ![](https://webarchive.library.unt.edu/eot2008/20081005085642im_/http://www.nci.nih.gov/images/spacer.gif) | NCI-C01810 Ro 4-6467/1 | | ![](https://webarchive.library.unt.edu/eot2008/20081005085642im_/http://www.nci.nih.gov/images/spacer.gif) | Chemical structure names: | ![](https://webarchive.library.unt.edu/eot2008/20081005085642im_/http://www.nci.nih.gov/images/spacer.gif) | - benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI)
- N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide
- N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine
- N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide
- N-Methylhydrazine
- p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide
- p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride
- p-toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI)
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