BRENDA Comprehensive Enzyme System(http://www.brenda.uni-koeln.de/)
Started in 1986, BRENDA contains functional data for over 3,500
different enzymes. The data collection is being developed into a
metabolic network information system with links to Enzyme expression
and regulation information. Comprehensive search features based
on nomenclature, reaction and specificity, enzyme structure, stability,
disease, sequence, and application.
Candidate Genes to Inherited Disease (G2D) (http://www.ogic.ca/projects/g2d_2/)
Presents precomputed candidate genes for more than 600 genetically
inherited diseases that have been mapped onto chromosomal regions
without assignment of a particular gene. Search by phenotype,
known gene, or chromosome/locus
Complete Genome Tracking Database(http://cgg.ebi.ac.uk/services/cogent/)
A single resource containing predicted peptides from all publicly
available fully sequenced genomes. Information includes the full
name of the genome being added, its taxonomic classification and
information regarding the location and date of its sequencing.
European
Bioinformatics Institute (EBI)(http://www.ebi.ac.uk/)
The EMBL Nucleotide Sequence Database, SWISS-PROT Protein Sequence
Database and other EBI databases are available through this site.
An outstation of EMBL.
ExPASy(http://us.expasy.org/
Includes access to numerous protein databases and Sequence Analysis
Tools from ExPASy.
GeneGateway(http://www.ornl.gov/sci/techresources/Human_Genome/posters/chromosome/)
Collection of guides and tutorials designed to help students and
other novice users get started with some of the resources that make
these data available to the public.
Gene
Ontology(http://www.geneontology.org/)
Goal is to produce a dynamic controlled vocabulary that can be applied
to all organisms, even as knowledge of gene and protein roles in
cells is accumulating and changing.
Genome
Gateway: The Human Genome (Nature, 409:6822)(http://www.nature.com/genomics/human/) and The
Human Genome (Science, 291:5507)(http://www.sciencemag.org/content/vol291/issue5507/)
Publications of the comprehensive sequencing and analysis of the
human genome as of February, 2001. These are the seminal sites for
information about the human gene map.
Genome
Programs(http://megasun.bch.umontreal.ca/other/genomes.html)
Links to genome sequencing projects for humans and other organisms.
Produced by the Organelle Genome Megasequencing Program, a collaboration
of Canadian research groups.
The
Human Gene Map(http://www.ncbi.nlm.nih.gov/genemap/)
The most current map resulting from the Human Genome Project.
Human Protein Atlas(http://www.hpr.se/)
The Human Protein Atlas shows the expression and localization of proteins in a large variety of normal human tissues and cancer cells. The data is presented as high resolution images representing immunohistochemically stained tissue sections. Available proteins (genes) can be reached through a specific search (by gene/protein name/id or classification, such as kinase or protease) or by browsing the individual chromosomes
NCBI
Genes and Disease(http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd) Genes and Disease is a collection of articles that discuss
genes and the diseases that they cause. These genetic disorders
are organized by the parts of the body that they affect.
HUM-MOLGEN
(Human Molecular Genetics)(http://www.hum-molgen.de/)
Premier portal site on human molecular genetics. Includes news,
trends in specific fields and internet resources, such as a directory
of biomedical companies, journals, conferences, etc.
JAX
Mouse Genome Informatics(http://www.informatics.jax.org/)
Integrated access to data on the genetics, genomics and biology
of the laboratory mouse.
Mouse
Atlas Project(http://genex.hgu.mrc.ac.uk/)
Digital atlases of mouse and human embryo development and the “Emage”
database of 2D and 3D gene expression patterns during mouse embryo
development.
National
Center for Biotechnology Information(http://www.ncbi.nlm.nih.gov/)
Information center within the National Library of Medicine dealing
with information on genetic research, the Human Genome Project,
the ENTREZ browser, GenBank and other searchable sequence databases.
PharmGKB(http://www.pharmgkb.org/)
This knowledge base is a central repository for genetic and clinical
data to aid researchers in understanding how genetic variation among
individuals contributes to differences in drug reactions. Information
is arranged by gene, drug, clinical outcome, drug response, pharmacokinetics,
and molecular and cellular functional assays. The data is derived
from individuals participating in the Pharmacogenetics Research
Network Studies.
The
RCSB Protein Data Bank(http://www.rcsb.org/pdb/)
The Research Collaboratory for Structural Bioinformatics (RCSB)
has developed the “single worldwide repository for the processing
and distribution of 3-D biological macromolecular structure data.”
STITCH: Chemical-Protein Interactions(http://stitch.embl.de/)
STITCH (Search Tool for Interactions of Chemicals') integrates information about interactions from metabolic pathways, crystal structures, binding experiments and drug-target relationships. Inferred information from phenotypic effects, text mining and chemical structure similarity is used to predict relations between chemicals. Each proposed interaction can be traced back to the original data sources. The database contains interaction information for over 68 000 different chemicals, including 2200 drugs, and connects them to 1.5 million genes across 373 genomes and their interactions contained in the STRING database.
TIGR
Database (TDB)(http://www.tigr.org/db.shtml)
A collection of curated databases containing DNA and protein sequence,
gene expression, etc, for microbes, plants and humans. From the
Institute for Genomic Research.
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