![](https://webarchive.library.unt.edu/eot2008/20081005062843im_/http://www.nci.nih.gov/images/spacer.gif) |
|
![](https://webarchive.library.unt.edu/eot2008/20081005062843im_/http://www.nci.nih.gov/images/spacer.gif)
KW-2149 A semisynthetic water-soluble disulfide derivative of the antineoplastic antibiotic mitomycin C. Activated by serum and glutathione, KW-2149 causes interstrand DNA cross-links and DNA-protein cross-links, resulting in single-strand DNA breaks and inhibition of DNA synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
![](https://webarchive.library.unt.edu/eot2008/20081005062843im_/http://www.nci.nih.gov/images/spacer.gif)
Code names: | ![](https://webarchive.library.unt.edu/eot2008/20081005062843im_/http://www.nci.nih.gov/images/spacer.gif) | KT6149 KW 2149 | | ![](https://webarchive.library.unt.edu/eot2008/20081005062843im_/http://www.nci.nih.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20081005062843im_/http://www.nci.nih.gov/images/spacer.gif) | 7-N-(2-((2-(gamma-L-Glutamylamino)ethyl)dithio)ethyl)mitomycin C | | ![](https://webarchive.library.unt.edu/eot2008/20081005062843im_/http://www.nci.nih.gov/images/spacer.gif) |
![](https://webarchive.library.unt.edu/eot2008/20081005062843im_/http://www.nci.nih.gov/images/spacer.gif)
![](https://webarchive.library.unt.edu/eot2008/20081005062843im_/http://www.nci.nih.gov/images/gray_spacer.gif)
![](https://webarchive.library.unt.edu/eot2008/20081005062843im_/http://www.nci.nih.gov/images/spacer.gif)
|
![](https://webarchive.library.unt.edu/eot2008/20081005062843im_/http://www.nci.nih.gov/images/spacer.gif) |