NHANES Working Group
A CDC-wide team is currently
collaborating with the National
Cancer Institute to measure
population variation in selected
genes using stored DNA samples
collected during the third
National Health and Nutrition
Examination Survey (NHANES) III.
|
Johnston County
Osteoarthritis Project
CDC and the University of
North Carolina are conducting
a community-based cohort
study of risk factors, including
genetics, for osteoarthritis in a
rural population. |
National Birth Defects
Prevention Study (NBDPS)
This ongoing case-control
study has collected DNA
samples by using cheek
swabs from enrolled children
and their parents, with over
5,000 samples received
in 2004.
|
HuGENet™
The Human Genome
Epidemiology Network
(HuGeNet™) co-sponsored a
workshop on meta-analysis of
gene-disease association data
with the Public Health Genetics
Unit in Cambridge, U.K. |
Stroke Prevention in Young
Women Study
This collaboration of CDC, the
University of Maryland and 59
hospitals in the Baltimore– Washington, D.C. area recently
published a study of ischemic
stroke in relation to genes in the
thrombomodulin-protein C
pathway.
|
Newborn Screening for
Cystic Fibrosis
A report with recommendations
for newborn screening for cystic
fibrosis was published in the
MMWR in October 2004,
summarizing results of a
workshop co-sponsored by CDC
and the Cystic Fibrosis
Foundation. |
Surveillance for Duchenne/Becker
Muscular Dystrophy (DBMD)
CDC is developing an approach to
single gene disorders based on
surveillance and improved
screening, diagnosis and services,
beginning with the Muscular
Dystrophy Surveillance Tracking
and Research Network (MD Starnet)
in Arizona, Colorado, Iowa, and
western New York state.
|
Analysis of Genetic Risk Factors
for Fatal Influenza in Children
CDC is conducting a case-control
study integrated with multi-state
population-based surveillance for
influenza-related hospitalizations
in children during the 2004-2005
season to identify genetic variants
that may put certain children at a
greater risk of mortality associated
with influenza. |
Molecular Signatures of Cervical
Neoplasia
As part of the National Cancer
Institute’s (NCI) Early Detection
Research Network, CDC has
detected and validated
biomarkers that can be used to
improve the sensitivity and
specificity of cervical cancer
screening. |
Rare Disease Genetic Testing
In collaboration with other HHS
agencies, professional
organizations, patient advocacy
groups, and Emory University,
CDC convened a conference: “Promoting Quality Laboratory
Testing for Rare Diseases: Keys to
Ensuring Quality Genetic Testing.”
|
Searching for a Flavivirus
Susceptibility or Resistance Gene
in West Nile Virus (WNV) Infection
CDC scientists are currently
collaborating with Georgia State
University to search for a flavivirus
susceptibility/resistance gene in
persons who were hospitalized for
WNV disease during the 2003 WNV
outbreak in Colorado.
|
Influence of Host Genetics on
Virological Failure of Highly
Active Anti-Retroviral Therapy
(HAART)
CDC investigators are studying the
effect of host genetics on
virological failure of HAART using a
HIV-infected adult cohort with
well-documented treatment
history. |
The Role of Host Genetic
Polymorphisms in Susceptibility
to M. Tuberculosis Infection
and Progression to TB Disease
CDC is working to identify genetic
risk factors for susceptibility to TB.
These could help TB programs in
other countries target costly
interventions to the 10% of
exposed persons truly at risk of
developing TB. |
Evaluation of Genomic
Applications in Practice and
Prevention (EGAPP)
CDC has assembled an
independent, non-Federal working
group of experts in epidemiology,
genomics, public health, laboratory
practice, medicine and health
services to demonstrate an
evidence-based review process for
genetic tests in transition from
research to clinical application.
|
Genetics of Kidneys in Diabetes
(GoKinD) Study
CDC is developing a repository of
DNA samples to study kidney
disease in adults with type 1
diabetes as part of a study
sponsored by the Juvenile Diabetes
Research Foundation, in
collaboration with the Joslin
Diabetes Center and George
Washington University.
|
Prevalence of Gene Variants
Coding for Enzymes Involved in
Nicotine and Carcinogen
Metabolism
CDC will genotype approximately
7,300 samples from the NHANES III
DNA Bank for genes associated
with nicotine metabolism. |
Chronic Beryllium Disease (CBD)
A sophisticated PCR-DNA sequencing assay has been developed to identify more precisely specific haplotypes associated with susceptibility to CBD. |
Genetic and Environmental
Factors in Brain Cancer
CDC is conducting a population-based
case-control study to assess
potential genetic susceptibility
factors in the excess risk of brain
cancer observed among persons
working in agriculture. |