| Agent Name |
2-Ethoxyethyl acetate |
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| Alternative Name |
Ethylene glycol monoethyl ether acetate |
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| CAS Number |
111-15-9 |
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| Formula |
C6-H12-O3 |
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| Major Category |
Solvents |
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| Synonyms |
1-Acetoxy-2-ethoxyethane; 2-Aethoxy-aethylacetat [German]; 2-Ethoxy-ethylacetaat [Dutch]; 2-Ethoxyethanol acetate; 2-Ethoxyethanol, ester with acetic acid; 2-Ethoxyethyl acetate; 2-Ethoxyethylacetate; 2-Ethoxyethyle, acetate de [French]; 2-Ethoxyethylester kyseliny octove [Czech]; 2-Etossietil-acetato [Italian]; Acetate d'ethylglycol [French]; Acetate de cellosolve [French]; Acetate de l'ether monoethylique de l'ethylene-glycol; [French]; Acetato di cellosolve [Italian]; Acetic acid, 2-ethoxyethyl ester; Aethylenglykolaetheracetat [German]; Cellosolve acetate; Celosolvacetat [Czech]; EGEEA; Ektasolve EE acetate solvent; Ethanol, 2-ethoxy-, acetate; Ethoxyethyl acetate; Ethyl cellosolve acetaat [Dutch]; Ethyl cellosolve acetate; Ethylene glycol ethyl ether acetate; Ethylene glycol monoethyl ether acetylated; Ethylene glycol monoethyl ether monoacetate; Ethyleneglycol monoethyl ether acetate; Ethylglycol acetate; Ethylglykolacetat [German]; Glycol ether EE acetate; Glycol monoethyl ether acetate; Octan etoksyetylu [Polish]; Oxitol acetate; Oxytol acetate; Poly-Solv EE acetate; [ChemIDplus] UN1172 |
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| Category |
Glycol Ethers |
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| Description |
Colorless liquid with a mild odor; [NIOSH] |
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| Sources/Uses |
Used as an industrial solvent; [ACGIH] |
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| Comments |
Laboratory animals die after twelve 8-hour exposures of 450 ppm; pathological examination shows kidney damage; [ACGIH] For ethylene glycol ethers, there is limited positive evidence of spontaneous abortions and decreased sperm counts in humans and strong positive evidence of birth defects and testicular damage in animals. [ATSDR Case Studies # 29] See "Glycol ethers." |
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| Exposure Assessment |
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| BEI |
2-Ethoxyacetic acid in urine = 100 mg/g creatinine; end of shift at end of workweek; |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
5 ppm |
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| PEL (OSHA) |
100 ppm |
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| MAK |
2 ppm |
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| IDLH (NIOSH) |
500 ppm |
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| Excerpts from Documentation for IDLHs |
Basis for original (SCP) IDLH: Patty [1963] reported that guinea pigs survived a 1�hour exposure to an atmosphere essentially saturated with vapor (estimated to be less than 4,000 ppm) [Lehmann and Flury 1943]. Because the data concerning the concentration is not very specific, the IDLH is based on the concentration of 2�ethoxyethylacetate in saturated air at 20 C (i.e., 2,600 ppm). . . . Human data: None relevant for use in determining the revised IDLH. |
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| Vapor Pressure |
2.34 mm Hg |
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| Odor Threshold Low |
0.06 ppm |
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| Odor Threshold High |
0.13 ppm |
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| Lethal Concentration |
LC50 (rats) = 12,100 mg/m3/8 hr |
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| Explanatory Notes |
Detection odor threshold from AIHA (mean = 0.06 ppm); Flash point = 47 degC; |
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| Half Life |
"The half life for elimination was 23.6 hours." [HSDB] |
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| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
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| Flammability (NFPA) |
2: high ambient temperature required |
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| Adverse Effects |
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| Neurotoxin |
CNS Solvent Syndrome |
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| Nephrotoxin |
Yes |
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| Reproductive Toxin |
Yes |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: ETHYLENE GLYCOL MONOETHYL ETHER ACETATE
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