| Agent Name |
Hexamethylene diisocyanate |
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| CAS Number |
822-06-0 |
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| Formula |
C8-H12-N2-O2 |
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| Major Category |
Plastics & Rubber |
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| Synonyms |
1,6-Diisocyanatohexane; 1,6-Hexamethylene diisocyanate; 1,6-Hexanediol diisocyanate; 1,6-Hexylene diisocyanate; HDI; HMDI; Hexamethylendiisokyanat [Czech]; Hexamethylene-1,6-diisocyanate; Hexane 1,6-diisocyanate; Hexane, 1,6-diisocyanato-; Isocyanic acid, diester with 1,6-hexanediol; Metyleno-bis-fenyloizocyjanian [Polish]; Szesciometylenodwuizocyjanian [Polish]; TL 78; [ChemIDplus] |
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| Category |
Diisocyanates |
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| Description |
Clear, colorless to slightly yellow liquid with a sharp, pungent odor; [NIOSH] |
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| Sources/Uses |
Used as a cross-linking agent to manufacture dental materials, contact lenses, medical adsorbents, and polyurethanes; may be released during the spraying of polyurethane paints; commonly used as a hardener in polyurethane automobile paints; [HSDB] Occupational asthma reported in a spray painter; [Malo] |
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| Comments |
"Isocyanate HP," a form of hypersensitivity pneumonitis, has been reported. [Rosenstock, p. 346] May cause skin sensitization; [ICSC] See "DIISOCYANATES." |
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| Reference Link |
ATSDR ToxFAQs - Hexamethylene Diisocyanate |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
0.005 ppm |
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| MAK |
0.005 ppm |
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| Vapor Pressure |
0.5 mm Hg |
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| Lethal Concentration |
LCLo (rats) = 60 mg/m3/4h |
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| Reference Link |
Evaluation of pulmonary function in workers exposed to hexamethylene diisocyanate |
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| Adverse Effects |
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| Asthma |
Yes |
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| Fibrogenic |
Yes |
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| Skin Sensitizer |
Yes |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: HEXAMETHYLENE DIISOCYANATE
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