| Agent Name |
o-Toluidine |
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| CAS Number |
95-53-4 |
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| Formula |
C7-H9-N |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
1-Amino-2-methylbenzene; 1-Methyl-2-aminobenzene; 2-Amino-1-methylbenzene; 2-Aminotoluene; 2-Methyl-1-aminobenzene; 2-Methylaniline; 2-Methylbenzamine; 2-Methylbenzenamine; 2-Toluidine; Aniline, 2-methyl-; C.I. 37077; o-Aminotoluene; o-Methylaniline; o-Methylbenzenamine; o-Toluidin [Czech]; o-Toluidine; o-Toluidyna [Polish]; o-Tolylamine; [ChemIDplus] UN1708 |
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| Category |
Amines, Aromatic |
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| Description |
Colorless to pale-yellow liquid with an aromatic, aniline-like odor; [NIOSH] |
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| Sources/Uses |
An intermediate used in the organic synthesis of dyes, pharmaceuticals, and other chemicals; [ACGIH] |
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| Comments |
Methemoglobinemia, bladder irritation, and hematuria have been reported in exposed workers. Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] May cause methemoglobinemia and kidney injury; [ICSC] |
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| Exposure Assessment |
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| BEI |
Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH] |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
2 ppm |
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| PEL (OSHA) |
5 ppm |
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| IDLH (NIOSH) |
50 ppm |
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| Excerpts from Documentation for IDLHs |
Human data: It has been reported that a 60�minute exposure to 40 ppm produces severe toxic effects [Goldblatt 1955]. It has been reported that 100 ppm is the maximum concentration endurable for 1 hour without serious consequences [Sax 1975]. |
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| Vapor Pressure |
0.3 mm Hg |
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| Odor Threshold Low |
0.02 ppm |
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| Odor Threshold High |
6.6 ppm |
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| Lethal Concentration |
LC50 (rats) = 862 ppm/4h |
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| Explanatory Notes |
Odor threshold from AIHA; Flash point = 185 deg F; |
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| Flammability (NFPA) |
2: high ambient temperature required |
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| Adverse Effects |
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| Methemoglobinemia |
Methemoglobinemia, Secondary |
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| Nephrotoxin |
Yes |
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| IARC Carcinogen |
Probable Carcinogen |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 2-AMINOTOLUENE
|
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