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Toxicological Profile

Toxicological Profile

September 2001

Asbestos Toxicological Profile PDF PDF Version, 3 MB

CAS#: 505-60-2

Toxicological Profile Information

The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. Each peer-reviewed profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties. Other pertinent literature is also presented, but is described in less detail than the key studies. The complete list of topics covered (chapter titles) is shown at the left and in more detail further down this page.

The focus of the profile is on health and toxicologic information. Therefore, each profile begins with a Public Health Statement that summarizes in nontechnical language, a substance's relevant properties.

A useful two page information sheet, the ToxFAQs, is also available.

Toxicological Profile Access

In order to access the ATSDR toxicological profiles' PDF files below, you must have Adobe Acrobat Reader .

You may download that program for free from this link to Adobe Exiting the ATSDR Web Site. and then use it to access (open) the files below that are labeled as PDF files.

Toxicological Profile PDF Complete Profile, 3 MB

The table of contents and list of individual PDF files are given below.

Preface PDF Preface, 203 KB

Public Health Statement PDF 1. Public Health Statement, 125 KB

1.1 What is this substance?
1.2 What happens to it when it enters the environment?
1.3 How might I be exposed to it?
1.4 How can it enter and leave my body?
1.5 How can it affect my health?
1.6 How can it affect children?
1.7 How can families reduce the risk of exposure?
1.8 Is there a medical test to determine whether I have been exposed to it?
1.9 What recommendations has the federal government made to protect human health?
1.10 Where can I get more information?

Relevance to Public Health PDF 2. Relevance to Public Health, 122 KB

2.1 Background and environmental exposures in the United States
2.2 Summary of health effects
2.3 Minimal risk levels (MRLS)

Health Effects PDF 3. Health Effects, 888 KB

3.1 Introduction
3.2 Discussion of health effects by route of exposure
3.3 Genotoxicity
3.4 Health effects in wildlife potentially relevant to human health
3.5 Toxicokinetics
3.5 Mechanisms of action
3.6 Toxicities mediated through the neuroendocrine axis
3.7 Children's susceptibility
3.8 Biomarkers of exposure and effect
3.9 Interactions with other chemicals
3.10 Populations that are unusually susceptible
3.11 Methods for reducing toxic effects
3.12 Adequacy of the database

Chemical and Physical Information PDF 4. Chemical and Physical Information, 147 KB

4.1 Chemical identity
4.2 Physical and chemical properties

Production, Import, Use, and Disposal PDF 5. Production, Import, Use, and Disposal, 111 KB

5.1 Production
5.2 Import/Export
5.3 Use
5.4 Disposal

Potential for Human Exposure PDF 6. Potential for Human Exposure, 262 KB

6.1 Overview
6.2 Releases to the environment
6.3 Environmental fate
6.4 Levels monitored or estimated in the environment
6.5 General population and occupational exposure
6.6 Exposures of children
6.7 Populations with potentially high exposure
6.8 Adequacy of the database

Analytical Methods PDF 7. Analytical Methods, 135 KB

7.1 Biological materials
7.2 Environmental samples
7.3 Adequacy of the database

Regulations and Advisories PDF 8. Regulations and Advisories, 136 KB

References PDF 9. References, 380 KB

Glossary PDF 10. Glossary, 126 KB

Appendices PDF Appendices, 1.5 MB

A. Minimal risk level worksheets
B. User's guide
C. Acronyms, abbreviations, and symbols
D. Risk assessment summary
E. Index
F. Chemical-SPECIFIC health consultation: tremolite-related asbestos


Agency for Toxic Substances and Disease Registry (ATSDR). 2001. Toxicological profile for Asbestos. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.


All ATSDR toxicological profile PDF files are electronic conversions from paper copy or other electronic ASCII text files. This conversion may have resulted in character translation or format errors. Users are referred to the original paper copy of the toxicological profile for the official text, figures, and tables. Original paper copies can be obtained via the directions on the toxicological profile home page, which also contains other important information about the profiles.

Where can I get more information?

ATSDR can tell you where to find occupational and environmental health clinics. Their specialists can recognize, evaluate, and treat illnesses resulting from exposure to hazardous substances. You can also contact your community or state health or environmental quality department if you have any more questions or concerns.

For more information, contact:
Agency for Toxic Substances and Disease Registry
Division of Toxicology and Environmental Medicine
1600 Clifton Road NE, Mailstop F-32
Atlanta, GA 30333
Phone: 1-800-232-4636 / TTY: 888-232-6348 
This page was updated on 10/01/2007