Education
and Training
Epidemiology and Prevention
of Vaccine-Preventable Diseases
Broadcast January & February, 2007
Updates
and Clarifications
-
Zoster
vaccine reconstitution. We stated in the Storage & Handling
segment of Session I (January 25) that zoster vaccine should
be reconstituted only with the diluent supplied with it. We
based this statement on the assumption that the volume of diluent
for zoster vaccine was larger than that for Merck's other live
viral vaccines. Merck has since informed us that the volume
of diluent for zoster vaccine is the same as that for MMR, Varivax,
and MMRV. Therefore, the diluents for these four vaccines
are interchangeable. (2/5/07)
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Alternative
Twinrix schedule.
The U.S. Food and Drug Administration (FDA) has approved Twinrix®
[Hepatitis A Vaccine (Inactivated) and Hepatitis B (Recombinant)
Vaccine], for an accelerated dosing schedule that consists of
three doses given within three weeks followed by a booster dose
at 12 months. The approval means Twinrix is now available on
a dosing schedule at 0, 7, 21-30 days, followed by a
booster dose at 12 months. The vaccine was first approved
for adults over age 18 years by the FDA in May 2001 on a 0,
1, 6-month dosing schedule. NOTE: The 4-day
grace period for minimum intervals does not apply
to this schedule. (4/3/07)
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