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Which Study Results Are the Most Helpful in Making Cancer Care Decisions?
    Posted: 06/12/2003



Introduction






Clinical Trials Are Experimental & Prospective






What's a Phase III Clinical Trial?






Controlled Studies Allow Comparisons






Randomization: Chance, Not Choice






To Blind or Not to Blind






Study Size Matters






Example 1: A Cancer Treatment Trial






Example 2: A Cancer Prevention Trial






Summary: Questions to Ask About a Cancer Study



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Summary: Questions to Ask About a Cancer Study

In summary, the following questions may help as you look through various cancer studies, looking for the most medically definitive findings:

Question
Look For
  • Was the study a clinical trial? In other words, was the study experimental (there was an intervention that people were asked to take or do) and prospective (investigators followed study participants forward in time)?
A study that is both
experimental and prospective
  • What phase was the trial -- phase I, phase II or phase III?
A phase III study
  • Did the clinical trial have a control group? That is, did one group of participants receive the experimental intervention while another did not?
A controlled study
  • Were participants randomly assigned to either the investigational group or the control group?
A randomized study
  • How many participants were enrolled in the study?
A study that is large enough for the results to be statistically significant;
not due to chance

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