| Agent Name |
NITROSAMINES |
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| Alternative Name |
CLASS |
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| Major Category |
Nitrogen Compounds |
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| Category |
Nitrosamines |
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| Sources/Uses |
Nitrosamines are organic chemicals which contain =N-N=O attached to an alkyl or aryl group. Nitrosamines are produced in foundry, tanning, and rubber manufacturing processes. Nitrosamines are carcinogens in experimental animals. [Hawley] Sources of exposure include cigarette smoking, cured or smoked meat and fish, metalworking fluids, rubber vulcanization, leather tanning, and endogenous nitrosation of drugs in the stomach. [Rom, p. 1229-31] |
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| Comments |
"The acute toxicity of the dialkylnitrosamines decreases with increasing chain length." [ACGIH] N-nitrosodimethylamine (NDMA) has caused fatal hepatic necrosis after acute exposure and liver cirrhosis after chronic exposure. [LaDou, p. 464] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Not evaluated |
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| Adverse Effects |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Links to Other NLM Databases |
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