| Agent Name |
Diisopropylamine |
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| CAS Number |
108-18-9 |
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| Formula |
C6-H15-N |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
2-Propanamine, N-(1-methylethyl)-; N-(1-Methylethyl)-2-propanamine; N-Isopropyl-1-amino-2-methylethane; [ChemIDplus] UN1158 |
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| Category |
Amines, Aliphatic |
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| Description |
Colorless liquid with an ammonia- or fish-like odor; [NIOSH] |
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| Sources/Uses |
Used as a catalyst and chemical intermediate; [ACGIH] Used to soften hides in the tanning industry; [ILO Encyclo. Vol 4:104.1-104.416] Many aliphatic amines are used as curing agents for epoxy resins. [Sullivan, p. 473] |
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| Comments |
Liquid causes first degree burns on short exposure; [CHRIS] Corrosive to skin; [Quick CPC] Diisopropylamine is a severe pulmonary irritant in acute and chronic animal studies. At concentrations of 25 to 50 ppm, workers have experienced transient corneal injury, nausea, and headache. [ACGIH] Pulmonary edema may result from inhalation of high concentrations. [NJ-HSFS] A corrosive substance that causes lacrimation and may cause lung edema after inhalation of high concentrations; [ICSC] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
5 ppm |
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| PEL (OSHA) |
5 ppm |
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| IDLH (NIOSH) |
200 ppm |
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| Excerpts from Documentation for IDLHs |
Human data: Complaints of nausea, headache, and temporary dimness in vision were reported in workers 2 to 3 hours following several 5� to 10�minute exposures to about 176 ppm; concentrations otherwise during the workshift averaged about 24 to 48 ppm [Treon et al. 1949] |
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| Vapor Pressure |
79.4 mm Hg |
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| Odor Threshold Low |
0.13 ppm |
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| Lethal Concentration |
LC50 (rats) = 4,800 mg/m3/2h |
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| Explanatory Notes |
Detection odor threshold from AIHA (mean = 0.13 ppm); Flash point = -1 deg C; |
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| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
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| Flammability (NFPA) |
3: may ignite at ambient temperature |
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| Adverse Effects |
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| Toxic Pneumonitis |
Yes |
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| Dermatotoxin |
Skin Burns |
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| Lacrimator |
Yes |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: DIISOPROPYLAMINE
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