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Causal Agent:
Ascaris lumbricoides is
the largest nematode (roundworm) parasitizing the human intestine. (Adult females:
20 to 35 cm; adult male: 15 to 30 cm.)
Life Cycle:
Adult worms
live in the lumen of the small intestine. A female may produce approximately 200,000 eggs per day,
which are passed with the feces
.
Unfertilized eggs may be ingested but are not infective. Fertile eggs embryonate and become infective after 18 days to several weeks
,
depending on the environmental conditions (optimum: moist, warm, shaded soil). After
infective eggs are swallowed
, the
larvae hatch
, invade
the intestinal mucosa, and are carried via the portal, then systemic circulation to the
lungs
. The larvae mature further in the lungs
(10 to 14 days), penetrate the alveolar walls, ascend
the bronchial tree to the throat, and are swallowed
. Upon reaching the small intestine, they develop into adult worms
. Between 2 and 3 months are required from ingestion of the infective eggs to oviposition by
the adult female. Adult worms can live 1 to 2 years.
Geographic
Distribution:
The most common human
helminthic infection. Worldwide distribution. Highest prevalence in tropical
and subtropical regions, and areas with inadequate sanitation. Occurs in rural areas
of the southeastern United States.
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