| | Education The Rough Guide to In Silico Function Prediction, or How To Use Sequence and Structure Information To Predict Protein Function Marco Punta and Yanay Ofran PLoS Comput Biol. 2008 October; 4(10): e1000160. Published online 2008 October 31. doi: 10.1371/journal.pcbi.1000160.PMCID: PMC2518264 Support Vector Machines and Kernels for Computational Biology Asa Ben-Hur, Cheng Soon Ong, Sören Sonnenburg, Bernhard Schölkopf, and Gunnar Rätsch PLoS Comput Biol. 2008 October; 4(10): e1000173. Published online 2008 October 31. doi: 10.1371/journal.pcbi.1000173.PMCID: PMC2547983 Review Defrosting the Digital Library: Bibliographic Tools for the Next Generation Web Duncan Hull, Steve R. Pettifer, and Douglas B. Kell PLoS Comput Biol. 2008 October; 4(10): e1000204. Published online 2008 October 31. doi: 10.1371/journal.pcbi.1000204.PMCID: PMC2568856 Research Articles Discarding Functional Residues from the Substitution Table Improves Predictions of Active Sites within Three-Dimensional Structures Sungsam Gong and Tom L. Blundell PLoS Comput Biol. 2008 October; 4(10): e1000179. Published online 2008 October 3. doi: 10.1371/journal.pcbi.1000179.PMCID: PMC2527532 A Learning Theory for Reward-Modulated Spike-Timing-Dependent
Plasticity with Application to Biofeedback Robert Legenstein, Dejan Pecevski, and Wolfgang Maass PLoS Comput Biol. 2008 October; 4(10): e1000180. Published online 2008 October 10. doi: 10.1371/journal.pcbi.1000180.PMCID: PMC2543108 Removal of AU Bias from Microarray mRNA Expression Data Enhances Computational Identification of Active MicroRNAs Ran Elkon and Reuven Agami PLoS Comput Biol. 2008 October; 4(10): e1000189. Published online 2008 October 3. doi: 10.1371/journal.pcbi.1000189.PMCID: PMC2533120 Protein Docking by the Underestimation of Free Energy Funnels in the Space of Encounter Complexes Yang Shen, Ioannis Ch. Paschalidis, Pirooz Vakili, and Sandor Vajda PLoS Comput Biol. 2008 October; 4(10): e1000191. Published online 2008 October 10. doi: 10.1371/journal.pcbi.1000191.PMCID: PMC2538569 Nonidentifiability of the Source of Intrinsic Noise in Gene
Expression from Single-Burst Data Piers J. Ingram, Michael P. H. Stumpf, and Jaroslav Stark PLoS Comput Biol. 2008 October; 4(10): e1000192. Published online 2008 October 10. doi: 10.1371/journal.pcbi.1000192.PMCID: PMC2538572 Analysis of Gene Regulatory Networks in the Mammalian Circadian Rhythm Jun Yan, Haifang Wang, Yuting Liu, and Chunxuan Shao PLoS Comput Biol. 2008 October; 4(10): e1000193. Published online 2008 October 10. doi: 10.1371/journal.pcbi.1000193.PMCID: PMC2543109 The Inactivation Principle: Mathematical Solutions Minimizing the
Absolute Work and Biological Implications for the Planning of Arm Movements Bastien Berret, Christian Darlot, Frédéric Jean, Thierry Pozzo, Charalambos Papaxanthis, and Jean Paul Gauthier PLoS Comput Biol. 2008 October; 4(10): e1000194. Published online 2008 October 24. doi: 10.1371/journal.pcbi.1000194.PMCID: PMC2561290 Impact of Limited Solvent Capacity on Metabolic Rate, Enzyme Activities, and Metabolite Concentrations of S. cerevisiae Glycolysis Alexei Vazquez, Marcio A. de Menezes, Albert-László Barabási, and Zoltan N. Oltvai PLoS Comput Biol. 2008 October; 4(10): e1000195. Published online 2008 October 10. doi: 10.1371/journal.pcbi.1000195.PMCID: PMC2533405 Noise during Rest Enables the Exploration of the Brain's Dynamic Repertoire Anandamohan Ghosh, Y. Rho, A. R. McIntosh, R. Kötter, and V. K. Jirsa PLoS Comput Biol. 2008 October; 4(10): e1000196. Published online 2008 October 10. doi: 10.1371/journal.pcbi.1000196.PMCID: PMC2551736 Dose-to-Duration Encoding and Signaling beyond Saturation in Intracellular Signaling Networks Marcelo Behar, Nan Hao, Henrik G. Dohlman, and Timothy C. Elston PLoS Comput Biol. 2008 October; 4(10): e1000197. Published online 2008 October 10. doi: 10.1371/journal.pcbi.1000197.PMCID: PMC2543107 Biophysical Basis for Three Distinct Dynamical Mechanisms of Action
Potential Initiation Steven A. Prescott, Yves De Koninck, and Terrence J. Sejnowski PLoS Comput Biol. 2008 October; 4(10): e1000198. Published online 2008 October 10. doi: 10.1371/journal.pcbi.1000198.PMCID: PMC2551735 Aggregation Propensity of the Human Proteome Elodie Monsellier, Matteo Ramazzotti, Niccolò Taddei, and Fabrizio Chiti PLoS Comput Biol. 2008 October; 4(10): e1000199. Published online 2008 October 17. doi: 10.1371/journal.pcbi.1000199.PMCID: PMC2557143 Fusion and Fission of Genes Define a Metric between Fungal Genomes Pascal Durrens, Macha Nikolski, and David Sherman PLoS Comput Biol. 2008 October; 4(10): e1000200. Published online 2008 October 24. doi: 10.1371/journal.pcbi.1000200.PMCID: PMC2557144 ChromaSig: A Probabilistic Approach to Finding Common Chromatin Signatures in the Human Genome Gary Hon, Bing Ren, and Wei Wang PLoS Comput Biol. 2008 October; 4(10): e1000201. Published online 2008 October 17. doi: 10.1371/journal.pcbi.1000201.PMCID: PMC2556089 An End to Endless Forms: Epistasis, Phenotype Distribution Bias, and
Nonuniform Evolution Elhanan Borenstein and David C. Krakauer PLoS Comput Biol. 2008 October; 4(10): e1000202. Published online 2008 October 24. doi: 10.1371/journal.pcbi.1000202.PMCID: PMC2562988 Organization of Physical Interactomes as Uncovered by Network Schemas Eric Banks, Elena Nabieva, Bernard Chazelle, and Mona Singh PLoS Comput Biol. 2008 October; 4(10): e1000203. Published online 2008 October 24. doi: 10.1371/journal.pcbi.1000203.PMCID: PMC2561054 Cell Groups Reveal Structure of Stimulus Space Carina Curto and Vladimir Itskov PLoS Comput Biol. 2008 October; 4(10): e1000205. Published online 2008 October 31. doi: 10.1371/journal.pcbi.1000205.PMCID: PMC2565599 Flux-Based Transport Enhancement as a Plausible Unifying Mechanism for Auxin Transport in Meristem Development Szymon Stoma, Mikael Lucas, Jérôme Chopard, Marianne Schaedel, Jan Traas, and Christophe Godin PLoS Comput Biol. 2008 October; 4(10): e1000207. Published online 2008 October 31. doi: 10.1371/journal.pcbi.1000207.PMCID: PMC2565506 The Effects of NR2 Subunit-Dependent NMDA Receptor Kinetics on Synaptic Transmission and CaMKII Activation David M. Santucci and Sridhar Raghavachari PLoS Comput Biol. 2008 October; 4(10): e1000208. Published online 2008 October 31. doi: 10.1371/journal.pcbi.1000208.PMCID: PMC2563690 Genome-Scale Reconstruction and Analysis of the Pseudomonas
putida KT2440 Metabolic Network Facilitates Applications in
Biotechnology Jacek Puchałka, Matthew A. Oberhardt, Miguel Godinho, Agata Bielecka, Daniela Regenhardt, Kenneth N. Timmis, Jason A. Papin, and Vítor A. P. Martins dos Santos PLoS Comput Biol. 2008 October; 4(10): e1000210. Published online 2008 October 31. doi: 10.1371/journal.pcbi.1000210.PMCID: PMC2563689 |