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Volume 4(10);  October 2008
Education
The Rough Guide to In Silico Function Prediction, or How To Use Sequence and Structure Information To Predict Protein Function
Marco Punta and Yanay Ofran
PLoS Comput Biol. 2008 October; 4(10): e1000160. Published online 2008 October 31. doi: 10.1371/journal.pcbi.1000160.
PMCID: PMC2518264
Support Vector Machines and Kernels for Computational Biology
Asa Ben-Hur, Cheng Soon Ong, Sören Sonnenburg, Bernhard Schölkopf, and Gunnar Rätsch
PLoS Comput Biol. 2008 October; 4(10): e1000173. Published online 2008 October 31. doi: 10.1371/journal.pcbi.1000173.
PMCID: PMC2547983
Review
Defrosting the Digital Library: Bibliographic Tools for the Next Generation Web
Duncan Hull, Steve R. Pettifer, and Douglas B. Kell
PLoS Comput Biol. 2008 October; 4(10): e1000204. Published online 2008 October 31. doi: 10.1371/journal.pcbi.1000204.
PMCID: PMC2568856
Research Articles
Discarding Functional Residues from the Substitution Table Improves Predictions of Active Sites within Three-Dimensional Structures
Sungsam Gong and Tom L. Blundell
PLoS Comput Biol. 2008 October; 4(10): e1000179. Published online 2008 October 3. doi: 10.1371/journal.pcbi.1000179.
PMCID: PMC2527532
A Learning Theory for Reward-Modulated Spike-Timing-Dependent Plasticity with Application to Biofeedback
Robert Legenstein, Dejan Pecevski, and Wolfgang Maass
PLoS Comput Biol. 2008 October; 4(10): e1000180. Published online 2008 October 10. doi: 10.1371/journal.pcbi.1000180.
PMCID: PMC2543108
Removal of AU Bias from Microarray mRNA Expression Data Enhances Computational Identification of Active MicroRNAs
Ran Elkon and Reuven Agami
PLoS Comput Biol. 2008 October; 4(10): e1000189. Published online 2008 October 3. doi: 10.1371/journal.pcbi.1000189.
PMCID: PMC2533120
Protein Docking by the Underestimation of Free Energy Funnels in the Space of Encounter Complexes
Yang Shen, Ioannis Ch. Paschalidis, Pirooz Vakili, and Sandor Vajda
PLoS Comput Biol. 2008 October; 4(10): e1000191. Published online 2008 October 10. doi: 10.1371/journal.pcbi.1000191.
PMCID: PMC2538569
Nonidentifiability of the Source of Intrinsic Noise in Gene Expression from Single-Burst Data
Piers J. Ingram, Michael P. H. Stumpf, and Jaroslav Stark
PLoS Comput Biol. 2008 October; 4(10): e1000192. Published online 2008 October 10. doi: 10.1371/journal.pcbi.1000192.
PMCID: PMC2538572
Analysis of Gene Regulatory Networks in the Mammalian Circadian Rhythm
Jun Yan, Haifang Wang, Yuting Liu, and Chunxuan Shao
PLoS Comput Biol. 2008 October; 4(10): e1000193. Published online 2008 October 10. doi: 10.1371/journal.pcbi.1000193.
PMCID: PMC2543109
The Inactivation Principle: Mathematical Solutions Minimizing the Absolute Work and Biological Implications for the Planning of Arm Movements
Bastien Berret, Christian Darlot, Frédéric Jean, Thierry Pozzo, Charalambos Papaxanthis, and Jean Paul Gauthier
PLoS Comput Biol. 2008 October; 4(10): e1000194. Published online 2008 October 24. doi: 10.1371/journal.pcbi.1000194.
PMCID: PMC2561290
Impact of Limited Solvent Capacity on Metabolic Rate, Enzyme Activities, and Metabolite Concentrations of S. cerevisiae Glycolysis
Alexei Vazquez, Marcio A. de Menezes, Albert-László Barabási, and Zoltan N. Oltvai
PLoS Comput Biol. 2008 October; 4(10): e1000195. Published online 2008 October 10. doi: 10.1371/journal.pcbi.1000195.
PMCID: PMC2533405
Noise during Rest Enables the Exploration of the Brain's Dynamic Repertoire
Anandamohan Ghosh, Y. Rho, A. R. McIntosh, R. Kötter, and V. K. Jirsa
PLoS Comput Biol. 2008 October; 4(10): e1000196. Published online 2008 October 10. doi: 10.1371/journal.pcbi.1000196.
PMCID: PMC2551736
Dose-to-Duration Encoding and Signaling beyond Saturation in Intracellular Signaling Networks
Marcelo Behar, Nan Hao, Henrik G. Dohlman, and Timothy C. Elston
PLoS Comput Biol. 2008 October; 4(10): e1000197. Published online 2008 October 10. doi: 10.1371/journal.pcbi.1000197.
PMCID: PMC2543107
Biophysical Basis for Three Distinct Dynamical Mechanisms of Action Potential Initiation
Steven A. Prescott, Yves De Koninck, and Terrence J. Sejnowski
PLoS Comput Biol. 2008 October; 4(10): e1000198. Published online 2008 October 10. doi: 10.1371/journal.pcbi.1000198.
PMCID: PMC2551735
Aggregation Propensity of the Human Proteome
Elodie Monsellier, Matteo Ramazzotti, Niccolò Taddei, and Fabrizio Chiti
PLoS Comput Biol. 2008 October; 4(10): e1000199. Published online 2008 October 17. doi: 10.1371/journal.pcbi.1000199.
PMCID: PMC2557143
Fusion and Fission of Genes Define a Metric between Fungal Genomes
Pascal Durrens, Macha Nikolski, and David Sherman
PLoS Comput Biol. 2008 October; 4(10): e1000200. Published online 2008 October 24. doi: 10.1371/journal.pcbi.1000200.
PMCID: PMC2557144
ChromaSig: A Probabilistic Approach to Finding Common Chromatin Signatures in the Human Genome
Gary Hon, Bing Ren, and Wei Wang
PLoS Comput Biol. 2008 October; 4(10): e1000201. Published online 2008 October 17. doi: 10.1371/journal.pcbi.1000201.
PMCID: PMC2556089
An End to Endless Forms: Epistasis, Phenotype Distribution Bias, and Nonuniform Evolution
Elhanan Borenstein and David C. Krakauer
PLoS Comput Biol. 2008 October; 4(10): e1000202. Published online 2008 October 24. doi: 10.1371/journal.pcbi.1000202.
PMCID: PMC2562988
Organization of Physical Interactomes as Uncovered by Network Schemas
Eric Banks, Elena Nabieva, Bernard Chazelle, and Mona Singh
PLoS Comput Biol. 2008 October; 4(10): e1000203. Published online 2008 October 24. doi: 10.1371/journal.pcbi.1000203.
PMCID: PMC2561054
Cell Groups Reveal Structure of Stimulus Space
Carina Curto and Vladimir Itskov
PLoS Comput Biol. 2008 October; 4(10): e1000205. Published online 2008 October 31. doi: 10.1371/journal.pcbi.1000205.
PMCID: PMC2565599
Flux-Based Transport Enhancement as a Plausible Unifying Mechanism for Auxin Transport in Meristem Development
Szymon Stoma, Mikael Lucas, Jérôme Chopard, Marianne Schaedel, Jan Traas, and Christophe Godin
PLoS Comput Biol. 2008 October; 4(10): e1000207. Published online 2008 October 31. doi: 10.1371/journal.pcbi.1000207.
PMCID: PMC2565506
The Effects of NR2 Subunit-Dependent NMDA Receptor Kinetics on Synaptic Transmission and CaMKII Activation
David M. Santucci and Sridhar Raghavachari
PLoS Comput Biol. 2008 October; 4(10): e1000208. Published online 2008 October 31. doi: 10.1371/journal.pcbi.1000208.
PMCID: PMC2563690
Genome-Scale Reconstruction and Analysis of the Pseudomonas putida KT2440 Metabolic Network Facilitates Applications in Biotechnology
Jacek Puchałka, Matthew A. Oberhardt, Miguel Godinho, Agata Bielecka, Daniela Regenhardt, Kenneth N. Timmis, Jason A. Papin, and Vítor A. P. Martins dos Santos
PLoS Comput Biol. 2008 October; 4(10): e1000210. Published online 2008 October 31. doi: 10.1371/journal.pcbi.1000210.
PMCID: PMC2563689
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